Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Ayala King"'
1
Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas
Autor: Owen J. Sansom, Carolyn J.P. Jones, John R. P. Knight, Kirsteen J. Campbell, Rachel A. Ridgway, Sheila Bryson, Karen Blyth, Thomas G. Bird, Kate Dudek, Ayala King, Douglas Strathdee, Dritan Liko, David A. Stevenson, Anne E. Willis, Louise Mitchell, Jennifer P. Morton
Publikováno v: Liko, D, Mitchell, L, Campbell, K J, Ridgway, R A, Jones, C, Dudek, K, King, A, Bryson, S, Stevenson, D, Blyth, K, Strathdee, D, Morton, J P, Bird, T G, Knight, J R P, Willis, A E & Sansom, O J 2019, ' Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas ', Cell Death and Differentiation . https://doi.org/10.1038/s41418-019-0316-7
Cell death and differentiation
Liko, D, Mitchell, L, Campbell, K J, Ridgway, R A, Jones, C, Dudek, K, King, A, Bryson, S, Stevenson, D A, Blyth, K, Strathdee, D, Morton, J P, Bird, T G, Knight, J R P, Willis, A E & Sansom, O J 2019, ' Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas ', Cell Death and Differentiation, vol. 26, no. 12, pp. 2535-2550 . https://doi.org/10.1038/s41418-019-0316-7
RNA polymerase III (Pol-III) transcribes tRNAs and other small RNAs essential for protein synthesis and cell growth. Pol-III is deregulated during carcinogenesis; however, its role in vivo has not been studied. To address this issue, wemanipulated le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437d94e9d9662ea5a279999e0d3265f6
https://doi.org/10.1038/s41418-019-0316-7
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2
Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity
Autor: Imran Ahmad, Owen J. Sansom, Catriona A. Ford, Gemma Charlesworth, Michelle Welsh, Lorraine Rose, Ernest Mui, Mark Salji, Ee Hong Tan, Ayala King, Hing Y. Leung, Rob van't Hof, Carolyn J. Loveridge, Amanda Prior, Karen Blyth, Anna Daroszewska
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
SCIENTIFIC REPORTS
Scientific Reports
Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we obse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a29c88cdc696a48463c483f020b710e
http://link.springer.com/article/10.1038/s41598-017-13346-8
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4
Wnt signaling potentiates nevogenesis
Autor: Andrea B. Maier, Jeff S. Pawlikowski, Karen Blyth, Mark E. Drotar, John van Tuyn, Ayala King, Hong Wu, Peter D. Adams, Rachael N. Hewitt, Tony McBryan
Publikováno v: Pawlikowski, J S, McBryan, T, van Tuyn, J, Drotar, M E, Hewitt, R N, Maier, A B, King, A, Blyth, K, Wu, H & Adams, P D 2013, ' Wnt signaling potentiates nevogenesis ', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 40, pp. 16009-16014 . https://doi.org/10.1073/pnas.1303491110
Proceedings of the National Academy of Sciences of the United States of America, 110(40), 16009-16014. National Academy of Sciences
Pawlikowski, J S, McBryan, T, van Tuyn, J, Drotar, M E, Hewitt, R N, Maier, A B, King, A, Blyth, K, Wu, H & Adams, P D 2013, ' Wnt signaling potentiates nevogenesis ', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 40, pp. 16009-14 . https://doi.org/10.1073/pnas.1303491110
Proceedings of the National Academy of Sciences of the United States of America, 110(40), 16009-14. National Acad Sciences
Cellular senescence is a stable proliferation arrest associated with an altered secretory pathway (senescence-associated secretory phenotype). Cellular senescence is also a tumor suppressor mechanism, to which both proliferation arrest and senescence
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a287b84fcd3b67c8ab3209b37d7b796c
https://doi.org/10.1073/pnas.1303491110
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5
Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling
Autor: Jeffrey S. Pawlikowski, Claire Brock, Sheau-Chiann Chen, Lara Al-Olabi, Colin Nixon, Fiona McGregor, Simon Paine, Estelle Chanudet, Wendy Lambie, William M. Holmes, James M. Mullin, Ann Richmond, Hong Wu, Karen Blyth, Ayala King, Veronica A. Kinsler, Peter D. Adams
Publikováno v: The Journal of Investigative Dermatology
Congenital melanocytic nevus (CMN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classically melanotic cells within the central nervous system, most frequently caused by a mutation of NRAS codon 61. This con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d0ee36cde723dd3257e8d7704621dc
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6
Runx2 contributes to the regenerative potential of the mammary epithelium
Autor: Theresa Higgins, Susan M. Mason, Owen J. Sansom, Matthew J. Smalley, Alessandra I. Riggio, Ian Rosewell, Karen Blyth, Ayala King, Joanna S. Morris, Nicola Ferrari, Laura McDonald, Ewan R. Cameron, James C. Neil
Publikováno v: Scientific Reports
Although best known for its role in bone development and associated structures the transcription factor RUNX2 is expressed in a wide range of lineages, including those of the mammary gland. Previous studies have indicated that Runx2 can regulate aspe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232bf923dd7b630647e713c0372b2097
https://doi.org/10.1038/srep15658
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7
Research into cancer metabolomics: Towards a clinical metamorphosis
Autor: J. Henry M. Däbritz, Orianne Olivares, Eyal Gottlieb, Christina Halsey, Ayala King
Publikováno v: Seminars in celldevelopmental biology. 43
The acknowledgement that metabolic reprogramming is a central feature of cancer has generated high expectations for major advances in both diagnosis and treatment of malignancies through addressing metabolism. These have so far only been partially fu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec83673fd143aee0d34764c157fc5d19
https://pubmed.ncbi.nlm.nih.gov/26365277
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8
Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo
Autor: Matthew Eagen, Joshua L. Dunaief, Ayala King, Ching-Hwa Sung, Tzvete Dentchev, Shiming Chen, Noriko Esumi, Donald J. Zack
Publikováno v: Current Eye Research. 24:392-396
To identify and characterize retinoblastoma protein (pRb) binding proteins that may influence retinoblast proliferation and retinal pigment epithelial cell survival.The yeast two-hybrid system was used to screen a bovine retinal cDNA library and to c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04612922bb56fed0917dd54952e14dd
https://doi.org/10.1076/ceyr.24.5.392.8524
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9
Glucose metabolism and programmed cell death: an evolutionary and mechanistic perspective
Autor: Ayala King, Eyal Gottlieb
Publikováno v: Current opinion in cell biology. 21(6)
Over the last decade, cellular glucose metabolism has emerged as a central player in the mechanisms of programmed cell death (PCD). We examined the metabolic foundations of apoptosis from a Darwinian context and suggest that PCD has evolved from the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7e610a522031fcd6b3b035cca2d372
https://pubmed.ncbi.nlm.nih.gov/19850457
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