Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ayako Yachie-Kinoshita"'
Autor:
Shuo Jiang, Daniel Evans-Yamamoto, Dennis Bersenev, Sucheendra K. Palaniappan, Ayako Yachie-Kinoshita
Publikováno v:
SLAS Technology, Vol 29, Iss 3, Pp 100134- (2024)
Protocol standardization and sharing are crucial for reproducibility in life sciences. In spite of numerous efforts for standardized protocol description, adherence to these standards in literature remains largely inconsistent. Curation of protocols
Externí odkaz:
https://doaj.org/article/a4d198cb942043508ee76eab41c00e7e
Autor:
Shingo Tsuji, Takeshi Hase, Ayako Yachie-Kinoshita, Taiko Nishino, Samik Ghosh, Masataka Kikuchi, Kazuro Shimokawa, Hiroyuki Aburatani, Hiroaki Kitano, Hiroshi Tanaka
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract Background Identifying novel therapeutic targets is crucial for the successful development of drugs. However, the cost to experimentally identify therapeutic targets is huge and only approximately 400 genes are targets for FDA-approved drugs
Externí odkaz:
https://doaj.org/article/9f86af9cd7f64393aab1f2c94cd69a8e
Autor:
Tiam Heydari, Matthew A Langley, Cynthia L Fisher, Daniel Aguilar-Hidalgo, Shreya Shukla, Ayako Yachie-Kinoshita, Michael Hughes, Kelly M McNagny, Peter W Zandstra
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 2, p e1009907 (2022)
The increasing availability of single-cell RNA-sequencing (scRNA-seq) data from various developmental systems provides the opportunity to infer gene regulatory networks (GRNs) directly from data. Herein we describe IQCELL, a platform to infer, simula
Externí odkaz:
https://doaj.org/article/ac7a7750987c4461be0be648a96584c1
Autor:
Ayako Yachie‐Kinoshita, Kento Onishi, Joel Ostblom, Matthew A Langley, Eszter Posfai, Janet Rossant, Peter W Zandstra
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 1, Pp 1-16 (2018)
Abstract Pluripotent stem cells (PSCs) exist in multiple stable states, each with specific cellular properties and molecular signatures. The mechanisms that maintain pluripotency, or that cause its destabilization to initiate development, are complex
Externí odkaz:
https://doaj.org/article/636e86fc8cc5407ea6b8435720f6b893
Autor:
Yu Kato, Kimiyo Tabata, Takayuki Kimura, Ayako Yachie-Kinoshita, Yoichi Ozawa, Kazuhiko Yamada, Junichi Ito, Sho Tachino, Yusaku Hori, Masahiro Matsuki, Yukiko Matsuoka, Samik Ghosh, Hiroaki Kitano, Kenichi Nomoto, Junji Matsui, Yasuhiro Funahashi
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212513 (2019)
Lenvatinib is a multiple receptor tyrosine kinase inhibitor targeting mainly vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) receptors. We investigated the immunomodulatory activities of lenvatinib in the tumor microenvir
Externí odkaz:
https://doaj.org/article/a3add2de47a44a519a9f34fb4324f9ca
Autor:
Taiko Nishino, Ayako Yachie-Kinoshita, Akiyoshi Hirayama, Tomoyoshi Soga, Makoto Suematsu, Masaru Tomita
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71060 (2013)
Although intraerythrocytic ATP and 2,3-bisphophoglycerate (2,3-BPG) are known as direct indicators of the viability of preserved red blood cells and the efficiency of post-transfusion oxygen delivery, no current blood storage method in practical use
Externí odkaz:
https://doaj.org/article/722e79a5a9874d8aaaf2d59c6eae4c00
Autor:
Ayako Yachie-Kinoshita, Shingo Tsuji, Kazuro Shimokawa, Hiroyuki Aburatani, Masataka Kikuchi, Samik Ghosh, Hiroshi Tanaka, Taiko Nishino, Hiroaki Kitano, Takeshi Hase
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-15 (2021)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Identifying novel therapeutic targets is crucial for the successful development of drugs. However, the cost to experimentally identify therapeutic targets is huge and only approximately 400 genes are targets for FDA-approved drugs. As a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5983c3a82e07b2153a133abcfc77aa4a
https://doi.org/10.1186/s13195-021-00826-3
https://doi.org/10.1186/s13195-021-00826-3
Publikováno v:
Encyclopedia of Bioinformatics and Computational Biology (2)
The unprecedented development in novel and high throughput techniques to understand biology at multiple dimensions has opened unique challenges and opportunities for computational methodologies to harness “big data in biology” and extract actiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65db6b8eb3cfe919d4c23161e86ad2a5
https://doi.org/10.1016/b978-0-12-809633-8.20287-2
https://doi.org/10.1016/b978-0-12-809633-8.20287-2
Autor:
Kazunari Kaizu, Ayako Yachie-Kinoshita
Publikováno v:
Encyclopedia of Bioinformatics and Computational Biology (2)
The cell is the most basic building block of an organism, containing all materials and information to maintain life in various strategies and cell behavior is thus an ensemble of subsystem dynamics. Mathematical modeling provides a framework to descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d02e0267c52141ccbd6cd9ffdefa071
https://doi.org/10.1016/b978-0-12-809633-8.20294-x
https://doi.org/10.1016/b978-0-12-809633-8.20294-x
Publikováno v:
Encyclopedia of Bioinformatics and Computational Biology (3)
With the emergence of technologies providing high-quality, high-volume and high-dimensional data for biological systems, together with the dramatic advances in information and computational techniques, systems biology-driven approaches have empowered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23c14edea2ffdcf373e5cb2950ff7cf3
https://doi.org/10.1016/b978-0-12-809633-8.20079-4
https://doi.org/10.1016/b978-0-12-809633-8.20079-4