Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ayako Suematsu"'
Autor:
Shogo Ehata, Hiroshi Takayanagi, Masanori Tsutsumi, Ryunosuke Muro, Tatsuo Asano, Kazuo Okamoto, Tadashi Okamura, K. Hashimoto, Takeshi Nitta, Yuta Nakai, Ayako Suematsu
Publikováno v:
Nature Metabolism. 1:868-875
Receptor activator of NF-κB ligand (RANKL) is a multifunctional cytokine known to affect immune and skeletal systems, as well as oncogenesis and metastasis1–4. RANKL is synthesized as a membrane-bound molecule, and cleaved into its soluble form by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b399a720e5d0082b2341c5131d1d2368
https://doi.org/10.1038/s42255-019-0104-1
https://doi.org/10.1038/s42255-019-0104-1
Autor:
Sae Ochi, Yasuhito Tajiri, Junko Taka, Hiroshi Takayanagi, Tomoki Nakashima, Sakae Tanaka, Ayako Suematsu, Hiromi Oda, Kozo Nakamura
Publikováno v:
Modern Rheumatology. 17:17-23
Finding a means to ameliorate and prevent bone destruction is one of the urgent issues in the treatment of rheumatoid arthritis. Recent studies revealed bone-resorbing osteoclasts to be essential for arthritic bone destruction, but to date there has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a512d9c0499b788aeffd34c967406c
https://doi.org/10.1007/s10165-006-0531-1
https://doi.org/10.1007/s10165-006-0531-1
Autor:
Hiroshi Takayanagi, Ayako Suematsu
Publikováno v:
Japanese Journal of Clinical Immunology. 30:22-28
The immune and skeletal systems share a number of regulatory molecules including cytokines, signaling molecules, transcription factors and membrane receptors, in common. Consequently, the physiology and pathology of one system may very well affect th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44a52860ff99f634a51131c2910a2de
https://doi.org/10.2177/jsci.30.22
https://doi.org/10.2177/jsci.30.22
Autor:
Shizuo Akira, Kojiro Sato, Masahiro Shinohara, Yusuke Nagai, Tomomi Suda, Hideki Sanjo, Takako Negishi-Koga, Ayako Suematsu, Hiroshi Takayanagi, Eriko Sumiya
Publikováno v:
Biochemical and biophysical research communications. 463(4)
TAK1 (encoded by Map3k7 ) is a mitogen-activated protein kinase kinase kinase (MAP3K), which activates the transcription factors AP-1 and NF-κB in response to receptor activator of NF-κB ligand (RANKL) stimulation, thus constituting a key regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2a9a26ae43ce4216e97541e4b6e446
https://pubmed.ncbi.nlm.nih.gov/26102028
https://pubmed.ncbi.nlm.nih.gov/26102028
Autor:
Toshiyuki Takai, Kojiro Sato, Tomomi Suda, Eriko Sumiya, Kazuo Okamoto, Hiroshi Takayanagi, Hans Jürgen Gober, Takako Negishi-Koga, Ayako Suematsu, Shinichiro Sawa, Noriko Komatsu
Publikováno v:
Nature Communications. 6
Autoantibody production and immune complex (IC) formation are frequently observed in autoimmune diseases associated with bone loss. However, it has been poorly understood whether ICs regulate bone metabolism directly. Here we show that the level of o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96702eab865e89606faf7c177bc3de9a
https://doi.org/10.1038/ncomms7637
https://doi.org/10.1038/ncomms7637
Autor:
Tatsuhiko Kodama, Kazuo Okamoto, Kojiro Sato, Daniel J. Cua, Shizuo Akira, Yuho Kadono, Sakae Tanaka, Hiroshi Takayanagi, Ayako Suematsu, Akira Yamaguchi, Yoichiro Iwakura, Yasuyuki Morishita
Publikováno v:
The Journal of Experimental Medicine
In autoimmune arthritis, traditionally classified as a T helper (Th) type 1 disease, the activation of T cells results in bone destruction mediated by osteoclasts, but how T cells enhance osteoclastogenesis despite the anti-osteoclastogenic effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c51403aa647d2ab06c4dc9bac0e38c4
https://doi.org/10.1084/jem.20061775
https://doi.org/10.1084/jem.20061775
Autor:
Hiroshi Sakamoto, Hiromi Oda, Yasuko Koshihara, Tsuyoshi Yoshida, Toshiyuki Horiuchi, Seizo Yamamoto, Ayako Suematsu
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 86:3272-3278
Synovial fibroblasts, established in culture from patients with RA, were treated with proinflammatory cytokines and prostaglandin E(2) (PGE(2)) for 24 h. These cells enhanced the production and the messenger RNA expression of PTH-related peptide (PTH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2637b8a759969cac8861f2e792c3cf8
https://doi.org/10.1210/jcem.86.7.7687
https://doi.org/10.1210/jcem.86.7.7687
Autor:
Toshiyuki Takai, Keiichi Ohya, Sayaka Takemoto-Kimura, Tomoki Nakashima, Kojiro Sato, Akira Yamaguchi, Haruhiko Bito, Hiroshi Asahara, Tatsuhiko Kodama, Yasuyuki Morishita, Hiroshi Takayanagi, Kazuhiro Aoki, Talal A. Chatila, Ayako Suematsu
Publikováno v:
Nature medicine. 12(12)
Calcium (Ca2+) signaling is essential for a variety of cellular responses and higher biological functions. Ca2+/calmodulin-dependent kinases (CaMKs) and the phosphatase calcineurin activate distinct downstream pathways that are mediated by the transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407c59fbe1eb72e8d132ec8b6c1f2a97
https://pubmed.ncbi.nlm.nih.gov/17128269
https://pubmed.ncbi.nlm.nih.gov/17128269
Autor:
Tadatsugu Taniguchi, Eiji Kobayashi, Sunhwa Kim, Ayako Suematsu, Toshiyuki Takai, Hiroshi Takayanagi, Masanori Inui, Takako Koga, Kazuya Inoue, Toshio Iwata, Takashi Matozaki, Hiroshi Ohnishi, Tatsuhiko Kodama
Publikováno v:
Nature. 428(6984)
Costimulatory signals are required for activation of immune cells, but it is not known whether they contribute to other biological systems. The development and homeostasis of the skeletal system depend on the balance between bone formation and resorp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a169b99518161cea01c849307534988a
https://pubmed.ncbi.nlm.nih.gov/15085135
https://pubmed.ncbi.nlm.nih.gov/15085135
Autor:
R Okawara, Yasuko Koshihara, Dongyun Feng, Hideaki Ishibashi, Seizou Yamamoto, Ayako Suematsu
Publikováno v:
Mechanisms of ageing and development. 123(10)
The most reliable explanation for decreasing bone mass in elderly women is an imbalance of osteoclastic resorption and osteoblastic formation resulting from a relative increase in osteoclastic resorption. However, it is not clear whether an increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fd3468644b5301084e54aea79da678
https://pubmed.ncbi.nlm.nih.gov/12297335
https://pubmed.ncbi.nlm.nih.gov/12297335