Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ayako Ooishi"'
Protein denaturation is a ubiquitous process that occurs bothin vitroandin vivo. While the molecular understanding of the denatured structures of proteins is limited, it is commonly accepted that the loss of unique intramolecular contacts makes prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0555ce6fab46d6c4ed54c4e7c9ba1d3d
https://doi.org/10.1101/2022.09.19.508607
https://doi.org/10.1101/2022.09.19.508607
Autor:
Hideki Watanabe, Yutaka Isobe, Ayako Ooishi, Shinya Honda, Chuya Yoshida, Yasuto Nakai, Momoko Ueda
Publikováno v:
ACS Chemical Biology. 14:2729-2736
Protein-protein interactions that can be controlled by environmental triggers have immense potential in various biological and industrial applications. In the current study, we aimed to engineer a pH-dependent protein-protein interaction that employs
Publikováno v:
International journal of pharmaceutics. 605
Aggregation of protein therapeutics can lead to immunogenicity and loss of function in vivo. Its effective prevention requires an understanding of the conformational and colloidal stability of protein and the improvement of both. Granulocyte colony-s
Autor:
Suguru Ohno, Keisuke Kijima, Ayako Ooishi, Kazufumi Yoza, Rie Ukuda, Hiroaki Oroku, Tomoko Ganaha-Kikumura, Tsuyoshi Ooishi, Ayako Yamaguchi, Akiko Miyagi
Publikováno v:
Japanese Journal of Applied Entomology and Zoology. 55:241-247
沖縄の南西部に位置する先島諸島においては,ナミハダニ黄緑型Tetranychus urticae(green form)は稀な種であると思われてきたが,我々は,本諸島に属する宮古島の広範囲にわたるトウガン
Autor:
Kyoko Suto, Takayuki Odahara, Yanwen Feng, Shinya Honda, Hideki Watanabe, Hiroyuki Matsumaru, Ayako Ooishi
Publikováno v:
Journal of Biological Chemistry. 284:12373-12383
Protein-protein interaction in response to environmental conditions enables sophisticated biological and biotechnological processes. Aiming toward the rational design of a pH-sensitive protein-protein interaction, we engineered pH-sensitive mutants o
Publikováno v:
Journal of Biological Engineering
Background In antibody purification processes, the acidic buffer commonly used to elute the bound antibodies during conventional affinity chromatograph, can damage the antibody. Herein we describe the development of several types of affinity ligands
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 929
Optimizing antibody purification is crucial to overcoming a bottleneck in the costly manufacturing process for antibody therapy. To address this issue, we designed a pH-sensitive Staphylococcus aureus protein A variant that retained its innate stabil
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 57
A simple systematic approach using Fourier transform infrared (FTIR) spectroscopy, size exclusion chromatography (SEC) and design of experiments (DOE) techniques was applied to the analysis of aggregation factors for protein formulations in stress an
Autor:
Ayako Ooishi, Jun Miyake, Noriyuki Ishii, Takayuki Odahara, Masayuki Hara, Shinya Honda, H. Uedaira
Publikováno v:
Biochimica et biophysica acta. 1808(6)
Relationships between growth conditions and thermostability were examined for photosynthetic inner membranes (chromatophores) from Rhodopseudomonas viridis and Rhodospirillum rubrum of which morphology, lipid composition, and protein/lipid rate are r
Autor:
Yoshito Sawada, Takayuki Odahara, Masakazu Sekijima, Ayako Ooishi, Hideki Watanabe, Yusuke Kato, Kazuaki Harata, Miyuki Ishimura, Shinya Honda, Toshihiko Akiba
What is the smallest protein? This is actually not such a simple question to answer, because there is no established consensus among scientists as to the definition of a protein. We describe here a designed molecule consisting of only 10 amino acids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d40e768fd858e00471f4c77c2ab040
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100813774
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100813774