Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Ayako Makino"'
Autor:
Mingmei Xiong, Pritesh P. Jain, Jiyuan Chen, Aleksandra Babicheva, Tengteng Zhao, Mona Alotaibi, Nick H. Kim, Ning Lai, Amin Izadi, Marisela Rodriguez, Jifeng Li, Angela Balistrieri, Francesca Balistrieri, Sophia Parmisano, Xin Sun, Daniela Valdez‐Jasso, John Y‐J. Shyy, Patricia A. Thistlethwaite, Jian Wang, Ayako Makino, Jason X.‐J. Yuan
Publikováno v:
Pulmonary Circulation, Vol 11, Iss 4, Pp 1-17 (2021)
Pulmonary arterial hypertension is a progressive and fatal disease and rodents with experimental pulmonary hypertension (PH) are often used to study pathogenic mechanisms, identify therapeutic targets, and develop novel drugs for treatment. Here we d
Externí odkaz:
https://doaj.org/article/1cc8dfb4cf714cbb804698ca95dfda41
Autor:
Mohamed Ahmed, Nahla Zaghloul, Prisca Zimmerman, Nancy G. Casanova, Xiaoguang Sun, Jin H. Song, Vivian Reyes Hernon, Saad Sammani, Franz Rischard, Olga Rafikova, Ruslan Rafikov, Ayako Makino, Carrie L. Kempf, Sara M. Camp, Jian Wang, Ankit A. Desai, Yves Lussier, Jason X.‐J. Yuan, Joe G.N. Garcia
Publikováno v:
Pulmonary Circulation, Vol 11, Iss 4, Pp 1-14 (2021)
Pharmacologic interventions to halt/reverse the vascular remodeling and right ventricular dysfunction in pulmonary arterial hypertension (PAH) remains an unmet need. We previously demonstrated extracellular nicotinamide phosphoribosyltransferase (eNA
Externí odkaz:
https://doaj.org/article/01ea69ffb6ab44d592257d77dde80f26
Autor:
Rui Si, Jody Tori O. Cabrera, Atsumi Tsuji-Hosokawa, Rui Guo, Makiko Watanabe, Lei Gao, Yun Sok Lee, Jae-Su Moon, Brian T. Scott, Jian Wang, Anthony W. Ashton, Jaladanki N. Rao, Jian-Ying Wang, Jason X.-J. Yuan, Ayako Makino
Publikováno v:
JCI Insight, Vol 6, Iss 21 (2021)
Patients with diabetes with coronary microvascular disease (CMD) exhibit higher cardiac mortality than patients without CMD. However, the molecular mechanism by which diabetes promotes CMD is poorly understood. RNA-binding protein human antigen R (Hu
Externí odkaz:
https://doaj.org/article/6276e505da664ccaa86691d1f879b040
Autor:
Marisela Rodriguez, Jiyuan Chen, Pritesh P. Jain, Aleksandra Babicheva, Mingmei Xiong, Jifeng Li, Ning Lai, Tengteng Zhao, Moises Hernandez, Angela Balistrieri, Sophia Parmisano, Tatum Simonson, Ellen Breen, Daniela Valdez-Jasso, Patricia A. Thistlethwaite, John Y. -J. Shyy, Jian Wang, Joe G. N. Garcia, Ayako Makino, Jason X. -J. Yuan
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Excessive pulmonary artery (PA) smooth muscle cell (PASMC) proliferation and migration are implicated in the development of pathogenic pulmonary vascular remodeling characterized by concentric arterial wall thickening and arteriole muscularization in
Externí odkaz:
https://doaj.org/article/1995a8a050974260b9221a472c8505e7
Autor:
Gerburg K. Schwaerzer, Hema Kalyanaraman, Darren E. Casteel, Nancy D. Dalton, Yusu Gu, Seunghoe Lee, Shunhui Zhuang, Nisreen Wahwah, Jan M. Schilling, Hemal H. Patel, Qian Zhang, Ayako Makino, Dianna M. Milewicz, Kirk L. Peterson, Gerry R. Boss, Renate B. Pilz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show that mice carrying the same mutation recapitulate the human disease, and find that treatment with anti-oxidants in
Externí odkaz:
https://doaj.org/article/1bb1d770c1fc4afd9a8c4a6eaa023c6b
Autor:
Zhuoying Liu, Yixuan Zhang, Ji Youn Youn, Yabing Zhang, Ayako Makino, Jason X.-J. Yuan, Hua Cai
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 904 (2022)
The prevalent use of electronic cigarettes (e-cigarettes) has increased exponentially in recent years, especially in youth who are attracted to flavored e-cigarettes. Indeed, e-cigarette or vaping product use-associated lung injury (EVALI) cases star
Externí odkaz:
https://doaj.org/article/0153527efa904585a62ebc97c422127d
Autor:
Haiyang Tang, PhD, Kang Wu, MD, PhD, Jian Wang, MD, Sujana Vinjamuri, MD, MS, Yali Gu, MS, RN, Shanshan Song, MD, PhD, Ziyi Wang, MD, Qian Zhang, MD, Angela Balistrieri, Ramon J. Ayon, PhD, Franz Rischard, MD, Rebecca Vanderpool, PhD, Jiwang Chen, PhD, Guofei Zhou, PhD, Ankit A. Desai, MD, Stephen M. Black, PhD, Joe G.N. Garcia, MD, Jason X.-J. Yuan, MD, PhD, Ayako Makino, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 744-762 (2018)
Summary: Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial h
Externí odkaz:
https://doaj.org/article/7ab59fb0cf2a4a7e9cf3b59b50b2cd9f
Autor:
Rui Si, Qian Zhang, Jody Tori O. Cabrera, Qiuyu Zheng, Atsumi Tsuji‐Hosokawa, Makiko Watanabe, Susumu Hosokawa, Mingmei Xiong, Pritesh P. Jain, Anthony W. Ashton, Jason X.‐J. Yuan, Jian Wang, Ayako Makino
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 24 (2020)
Background Abnormal endothelial function in the lungs is implicated in the development of pulmonary hypertension; however, there is little information about the difference of endothelial function between small distal pulmonary artery (PA) and large p
Externí odkaz:
https://doaj.org/article/72b7ab7be03e420594a267b176ccf0b3
Autor:
Pritesh P. Jain, Susumu Hosokawa, Mingmei Xiong, Aleksandra Babicheva, Tengteng Zhao, Marisela Rodriguez, Shamin Rahimi, Kiana Pourhashemi, Francesca Balistrieri, Ning Lai, Atul Malhotra, John Y.-J. Shyy, Daniela Valdez-Jasso, Patricia A. Thistlethwaite, Ayako Makino, Jason X.-J. Yuan
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Hypoxic Pulmonary Vasoconstriction (HPV) is an important physiological mechanism of the lungs that matches perfusion to ventilation thus maximizing O 2 saturation of the venous blood within the lungs. This study emphasizes on principal pathways in th
Externí odkaz:
https://doaj.org/article/d3f232845d024d048532b4afcc9a8108
Autor:
Casey E. Romanoski, Xinshuai Qi, Shreya Sangam, Rebecca R. Vanderpool, Robert S. Stearman, Austin Conklin, Manuel Gonzalez-Garay, Franz Rischard, Ramon J. Ayon, Jian Wang, Tatum Simonson, Aleksandra Babicheva, Yinan Shi, Haiyang Tang, Ayako Makino, Yogendra Kanthi, Mark W. Geraci, Joe G.N. Garcia, Jason X.-J. Yuan, Ankit A. Desai
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues o
Externí odkaz:
https://doaj.org/article/e546fc30e21247319e378d3c525325af