Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Ayako M. Watabe"'
Autor:
Mieko Morishima, Sohta Matsumura, Suguru Tohyama, Takashi Nagashima, Ayumu Konno, Hirokazu Hirai, Ayako M. Watabe
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The amygdala plays a crucial role in aversive learning. In Pavlovian fear conditioning, sensory information about an emotionally neutral conditioned stimulus (CS) and an innately aversive unconditioned stimulus is associated with the lateral amygdala
Externí odkaz:
https://doaj.org/article/7f2aa61a902d42e8835adf9d154aaa0a
Autor:
Shun Hamada, Kaori Mikami, Shuhei Ueda, Masashi Nagase, Takashi Nagashima, Mikiyasu Yamamoto, Haruhiko Bito, Sayaka Takemoto-Kimura, Toshihisa Ohtsuka, Ayako M. Watabe
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Taste plays an essential role in the evaluation of food quality by detecting potential harm and benefit in what animals are about to eat and drink. While the affective valence of taste signals is supposed to be innately determined, taste pre
Externí odkaz:
https://doaj.org/article/15b12d5525784a3bab2d58777788175a
Autor:
Takashi Nagashima, Kaori Mikami, Suguru Tohyama, Ayumu Konno, Hirokazu Hirai, Ayako M. Watabe
Publikováno v:
Frontiers in Neural Circuits, Vol 17 (2023)
Appropriately responding to various sensory signals in the environment is essential for animal survival. Accordingly, animal behaviors are closely related to external and internal states, which include the positive and negative emotional values of se
Externí odkaz:
https://doaj.org/article/9568a7be92da4b348b9559bf738f112f
Autor:
Manabu Abe, Ena Nakatsukasa, Rie Natsume, Shun Hamada, Kenji Sakimura, Ayako M. Watabe, Toshihisa Ohtsuka
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract CRISPR/Cas-based genome editing has dramatically improved genetic modification technology. In situ electroporation called genome editing via oviductal nucleic acid delivery (GONAD), which eliminates the need for ex vivo embryo handling, is t
Externí odkaz:
https://doaj.org/article/6e693d17def141abbcc579b510db6af7
Autor:
Takashi Nagashima, Suguru Tohyama, Kaori Mikami, Masashi Nagase, Mieko Morishima, Atsushi Kasai, Hitoshi Hashimoto, Ayako M. Watabe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Feeding and stress are deeply related to each other, yet neural circuits how they interact are not fully understood. Here, the authors show that the parabrachial-to-parasubthalamic nucleus pathway is involved in fear-induced feeding suppression.
Externí odkaz:
https://doaj.org/article/1166a363c4d6474095d2ede7eedce4ae
Autor:
Toshiki Tsunogai, Toya Ohashi, Yohta Shimada, Takashi Higuchi, Ayaka Kimura, Ayako M. Watabe, Fusao Kato, Hiroyuki Ida, Hiroshi Kobayashi
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 448-460 (2022)
GM1-gangliosidosis is a progressive neurodegenerative glycosphingolipidosis resulting from a GLB1 gene mutation causing a deficiency of the lysosomal enzyme β-galactosidase, which leads to the abnormal accumulation of GM1 ganglioside in the central
Externí odkaz:
https://doaj.org/article/7324db0761c5449a83b52405a909083c
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-9 (2021)
Abstract The neuronal circuitry for pain signals has been intensively studied for decades. The external lateral parabrachial nucleus (PB) was shown to play a crucial role in nociceptive information processing. Previous work, including ours, has demon
Externí odkaz:
https://doaj.org/article/716412288abb43ce96a185dba25510e8
Autor:
Shun Hamada, Masashi Nagase, Tomohiko Yoshizawa, Akari Hagiwara, Yoshikazu Isomura, Ayako M. Watabe, Toshihisa Ohtsuka
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Hamada et al. engineer and utilise a channelrhodopsin-2 variant that is localized to presynaptic axon terminals. They demonstrate its use for circuitry mapping in vivo and thus provide a useful tool for future optogenetic experiments
Externí odkaz:
https://doaj.org/article/13bb96c2e73745bfae399a7b886c98d7
Autor:
Kensuke Matsumura, Kaoru Seiriki, Shota Okada, Masashi Nagase, Shinya Ayabe, Ikuko Yamada, Tamio Furuse, Hirotoshi Shibuya, Yuka Yasuda, Hidenaga Yamamori, Michiko Fujimoto, Kazuki Nagayasu, Kana Yamamoto, Kohei Kitagawa, Hiroki Miura, Nanaka Gotoda-Nishimura, Hisato Igarashi, Misuzu Hayashida, Masayuki Baba, Momoka Kondo, Shigeru Hasebe, Kosei Ueshima, Atsushi Kasai, Yukio Ago, Atsuko Hayata-Takano, Norihito Shintani, Tokuichi Iguchi, Makoto Sato, Shun Yamaguchi, Masaru Tamura, Shigeharu Wakana, Atsushi Yoshiki, Ayako M. Watabe, Hideyuki Okano, Kazuhiro Takuma, Ryota Hashimoto, Hitoshi Hashimoto, Takanobu Nakazawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
De novo mutations significantly contribute to autism spectrum disorders (ASD). Here, the authors demonstrate that ASD-associated de novo mutations in the POGZ gene, one of a high-confidence ASD gene, lead to ASD-related impaired neuronal development
Externí odkaz:
https://doaj.org/article/b3970c6881ab49c4a520b80ed0ce7f6e
Autor:
Masanori Nomoto, Noriaki Ohkawa, Hirofumi Nishizono, Jun Yokose, Akinobu Suzuki, Mina Matsuo, Shuhei Tsujimura, Yukari Takahashi, Masashi Nagase, Ayako M. Watabe, Fusao Kato, Kaoru Inokuchi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Short-term memories (STM) can become long-term memories when occurring alongside novel experiences. Here, the authors investigate the neural mechanisms behind such 'behavioural tagging' and find STM neural populations are preferentially incorporated
Externí odkaz:
https://doaj.org/article/404ad47d5d1047cb896cd764c13ac056