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Publikováno v:
Bioorganicmedicinal chemistry. 26(8)
The fungus Aspergillus japonicus MF275 produces himeic acid A (1), containing a 4-pyrone ring, along with its congeners, himeic acids B (2) and C (3). During culture, 1 was gradually converted to 3, the corresponding 4-pyridone derivative. A study of
Publikováno v:
Chembiochem : a European journal of chemical biology. 19(6)
Himeic acid A, which is produced by the marine fungus Aspergillus japonicus MF275, is a specific inhibitor of the ubiquitin-activating enzyme E1 in the ubiquitin-proteasome system. To elucidate the mechanism of himeic acid biosynthesis, feeding exper
Publikováno v:
HETEROCYCLES. 98:558