Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Ayako Furukawa"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7409 (2024)
Advanced glycation end-products (AGEs) form through non-enzymatic glycation of various proteins. Optic nerve degeneration is a frequent complication of diabetes, and retinal AGE accumulation is strongly linked to the development of diabetic retinopat
Externí odkaz:
https://doaj.org/article/15a62359eb9c414fbb6656c3940c4765
Autor:
Ayako Furukawa, Masatoshi Wakamori, Yasuhiro Arimura, Hideaki Ohtomo, Yasuo Tsunaka, Hitoshi Kurumizaka, Takashi Umehara, Yoshifumi Nishimura
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105408- (2022)
Externí odkaz:
https://doaj.org/article/4c08afbc89814082b417b06881f3110d
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Diabetes mellitus (DM) has been identified as a risk factor for the onset and progression of Alzheimer’s disease (AD). In our previous study, we demonstrated that glyceraldehyde (GA)-derived toxic advanced glycation end-products (toxic AGEs, TAGE)
Externí odkaz:
https://doaj.org/article/dd31d2acdc744f1ab222b8603ed4e58c
Autor:
Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Yoshiki Koriyama, Chigusa Kikuchi, Ayako Furukawa, Kentaro Nagamine, Takamitsu Hori, Tamihide Matsunaga
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 387 (2021)
The habitual intake of large amounts of sugar, which has been implicated in the onset/progression of lifestyle-related diseases (LSRD), induces the excessive production of glyceraldehyde (GA), an intermediate of sugar metabolism, in neuronal cells, h
Externí odkaz:
https://doaj.org/article/7453680cd9fc4c03b2461a8e4bd73acf
Publikováno v:
Nutrients, Vol 12, Iss 10, p 2958 (2020)
Nutritional factors can affect the risk of developing neurological disorders and their rate of progression. In particular, abnormalities of carbohydrate metabolism in diabetes mellitus patients lead to an increased risk of neurological disorders such
Externí odkaz:
https://doaj.org/article/1cc1acd8d47f4ad3b271334a3393e481
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 394-396 (2015)
N-methyl-N-nitrosourea (MNU) is widely used to study the mechanism of retinal degenerative diseases (RDs) because of its selectivity of photoreceptor cell death. Many reports suggest that excessive nitric oxide (NO) plays a crucial role in neuronal c
Externí odkaz:
https://doaj.org/article/cf87aaa952304e9693c22d68025d7d18
Autor:
Ayako Furukawa, Yoshiyuki Kawamoto, Yoichi Chiba, Shiro Takei, Sanae Hasegawa-Ishii, Noriko Kawamura, Keisuke Yoshikawa, Masanori Hosokawa, Shinji Oikawa, Masashi Kato, Atsuyoshi Shimada
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 3, Pp 706-714 (2011)
Excitotoxicity is involved in seizure-induced acute neuronal death, hypoxic–ischemic encephalopathy, and chronic neurodegenerative conditions such as Alzheimer's disease. Although oxidative stress has been implicated in excitotoxicity, the target p
Externí odkaz:
https://doaj.org/article/c05e257c3fb24c3094174ef5afb0618c
Autor:
Yoshiki Koriyama, Ayako Furukawa
Publikováno v:
Neural Regeneration Research, Vol 11, Iss 11, Pp 1758-1759 (2016)
Externí odkaz:
https://doaj.org/article/d537127df7bf4cde98c8b919d79d9bc0
Autor:
Hideaki Ohtomo, Shinsuke Ito, Nicholas J. McKenzie, Michael Uckelmann, Masatoshi Wakamori, Haruhiko Ehara, Ayako Furukawa, Yasuo Tsunaka, Marika Shibata, Shun-ichi Sekine, Takashi Umehara, Chen Davidovich, Haruhiko Koseki, Yoshifumi Nishimura
Publikováno v:
Journal of molecular biology.
Polycomb repressive complex 1 (PRC1) and PRC2 are responsible for epigenetic gene regulation. PRC1 ubiquitinates histone H2A (H2Aub), which subsequently promotes PRC2 to introduce the H3 lysine 27 tri-methyl (H3K27me3) repressive chromatin mark. Alth
Publikováno v:
Current Opinion in Structural Biology. 75:102436
The structural unit of eukaryotic chromatin is a nucleosome, comprising two histone H2A/H2B heterodimers and one histone (H3/H4)