Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ayako, Yukita"'
Autor:
Koichi Takeya, Mariko Katsuyama, Yoshiaki Kamano, Ayako Yukita, George R. Pettit, Toshiaki Segawa, Ayano Yamashita, Kyoko Saito, Hideji Itokawa, Hiroshi Morita, Toshihiko Nogawa
Publikováno v:
Journal of Medicinal Chemistry. 45:5440-5447
QSAR analysis has been used to identify the essential structural requirements for increasing the inhibitory activities of selected bufadienolides from the Chinese drug Ch'an Su (and other sources) against the primary liver carcinoma cell line PLC/PRF
Publikováno v:
Japanese Journal of Cancer Research : Gann
Vascular endothelial growth factor (VEGF) is known as an angiogenic factor for tumor angiogene—sis. We developed a neutralizing anti—VEGF monoclonal antibody (MAb), MV833, and examined its antitumor activity against 27 human tumor cell lines tran
Autor:
Megumi Baba, Keigo Matsumoto, Ayako Yukita, Tatsuo Tanaka, Satoshi Nakamura, Hiroyuki Konno, Makoto Asano, Toshikazu Kanai, Hideo Suzuki, Shozo Baba
Publikováno v:
International Journal of Cancer. 77:933-936
In order to determine whether the inhibition of vascular-endothelial-growth-factor (VEGF) activity by administration of an immunoneutralizing antibody could suppress tumor growth and metastasis in spontaneous metastatic models of human colon and gast
Autor:
Toshikazu Kanai, Hideo Suzuki, Tomio Arai, Makoto Asano, Yasuhisa Naito, Satoshi Nakamura, Megumi Baba, Keigo Matsumoto, Shozo Baba, Tatsuo Tanaka, Ayako Yukita, Hiroyuki Konno, Haruhiko Sugimura
Publikováno v:
Japanese Journal of Cancer Research : Gann
Distant metastasis of gastrointestinal endocrine neoplasm is resistant to currently available treatments. Because hematogenic metastasis is dominant, anti-angiogenic drugs are expected to be a novel therapy for this neoplasm. In the present study, th
Publikováno v:
Hybridoma. 14:475-480
We have established monoclonal antibodies (MAbs) against human vascular endothelial growth factor/vascular permeability factor121 (VEGF/VPF121). Two (MV101 and MV303) of the 28 MAbs neutralized the mitogenic activity of VEGF/VPF121 on human umbilical
Autor:
Yoshiaki, Kamano, Ayano, Yamashita, Toshihiko, Nogawa, Hiroshi, Morita, Koichi, Takeya, Hideji, Itokawa, Toshiaki, Segawa, Ayako, Yukita, Kyoko, Saito, Mariko, Katsuyama, George R, Pettit
Publikováno v:
Journal of medicinal chemistry. 45(25)
QSAR analysis has been used to identify the essential structural requirements for increasing the inhibitory activities of selected bufadienolides from the Chinese drug Ch'an Su (and other sources) against the primary liver carcinoma cell line PLC/PRF
Autor:
Tomohisa Ichikawa, Toshiyuki Wakayama, Tetsuya Hasegawa, Takeo Kawaguchi, Hisatoyo Kato, Ayako Yukita, Toshiyuki Nagata, Mineo Saneyoshi
Publikováno v:
ChemInform. 31
Autor:
Takeo Kawaguchi, Toshiyuki Wakayama, Kato Hisatoyo, Tomohisa Ichikawa, Nagata Toshiyuki, Ayako Yukita, Tetsuya Hasegawa, Mineo Saneyoshi
Publikováno v:
Chemicalpharmaceutical bulletin. 48(4)
Sixteen derivatives of 1-(beta-D-arabinofuranosyl)-2-thiocytosine (araSC), including five 5'-esters, three 3'-esters, five N4-amides and three 5'-phosphodiesters, were synthesized and their reactivity to mouse tissue homogenates, including plasma, li
Autor:
Tatsuo Tanaka, Hiroyuki Konno, Kinji Kamiya, Makoto Asano, Hideo Suzuki, Ayako Yukita, Megumi Baba, Keigo Matsumoto, Takanori Sakaguchi, Satoshi Nakamura, Tomio Arai
Publikováno v:
Japanese Journal of Cancer Research : Gann
Induction of apoptosis by antiangiogenic therapy has been suggested as a new anticancer strategy. To clarify the mechanism of the antitumor effect achieved by inhibition of vascular endothelial growth factor (VEGF), which is a major mediator of angio
Autor:
Kato Hisatoyo, Tetsuya Hasegawa, Mineo Saneyoshi, Takeo Kawaguchi, Toshiyuki Wakayama, Makoto Asano, Tomohisa Ichikawa, Nagata Toshiyuki, Ayako Yukita
Publikováno v:
Biologicalpharmaceutical bulletin. 22(1)
1-(beta-D-Arabinofuranosyl)-2-thiocytosine (araSC), a 2-substituted derivative of cytarabine (araC), has been investigated for its cytotoxicity, enzymatic stability, plasma concentration-time profile in mice, and cytokinetics. This derivative showed