Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ayahisa Watanabe"'
Autor:
Yan Zhao, Keita Fukao, Songji Zhao, Ayahisa Watanabe, Tadateru Hamada, Kazuaki Yamasaki, Yoichi Shimizu, Naoki Kubo, Naoyuki Ukon, Toru Nakano, Nagara Tamaki, Yuji Kuge
Publikováno v:
Molecular Imaging, Vol 14 (2015)
The purpose of this study was to assess the usefulness of 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) in evaluating the antiatherogenic effects of irbesartan, an angiotensin II type 1 receptor blocker. Watanabe heritable hype
Externí odkaz:
https://doaj.org/article/601307604f334ce498124652d3a990dc
Autor:
Yan Zhao, Ayahisa Watanabe, Songji Zhao, Tatsuo Kobayashi, Keita Fukao, Yoshikazu Tanaka, Toru Nakano, Tetsuya Yoshida, Hiroshi Takemoto, Nagara Tamaki, Yuji Kuge
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89338 (2014)
To investigate the effects of irbesartan on inflammation and apoptosis in atherosclerotic plaques by histochemical examination and molecular imaging using (14)C-FDG and (99m)Tc-annexin A5.Irbesartan has a peroxisome proliferator-activated receptor ga
Externí odkaz:
https://doaj.org/article/b05c3cba9cba4af291a9de87b14a5bca
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1879-1886
Cyclic peptides have attracted increasing attention as a privileged class of molecules addressing undruggable targets. Cell permeability of cyclic peptides has remained a challenging issue owing to their molecular properties. Various efficiency metri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706f4e42f6bcf38be3ff53a561e5ead8
https://doi.org/10.1016/j.xphs.2022.03.019
https://doi.org/10.1016/j.xphs.2022.03.019
Autor:
Yoshifumi Kusumoto, Kyohei Hayashi, Soichiro Sato, Toru Yamada, Iori Kozono, Zenzaburo Nakata, Naoya Asada, Shungo Mitsuki, Ayahisa Watanabe, Chiaki Wakasa-Morimoto, Kentaro Uemura, Shuhei Arita, Shinobu Miki, Tohru Mizutare, Hidenori Mikamiyama
Publikováno v:
ACS medicinal chemistry letters. 13(10)
Human immunodeficiency virus type-1 (HIV-1) protease is essential for viral propagation, and its inhibitors are key anti-HIV-1 drug candidates. In this study, we discovered a novel HIV-1 protease inhibitor (compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce70e02630fb12dc340f6b4e77a44913
https://pubmed.ncbi.nlm.nih.gov/36262395
https://pubmed.ncbi.nlm.nih.gov/36262395
Autor:
Takayuki Katsube, Ayahisa Watanabe
Publikováno v:
Biopharmaceutics & Drug Disposition. 42:178-187
Conjugation with lipophilic ligands such as cholesterol and α-tocopherol dramatically improves the delivery and efficacy of antisense oligonucleotides (ASOs) in the liver. To estimate the hepatic ASO concentration and the efficacy of ASOs conjugated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced14801800edc3607ec61eeaea11ee2
https://doi.org/10.1002/bdd.2271
https://doi.org/10.1002/bdd.2271
Autor:
Masahide Odan, Shiho Yamamoto, Takayo Haruna, Shiro Kida, Yoshikazu Sasaki, Ayahisa Watanabe, Masaya Shimizu, Takayuki Okuno, Azumi Ueyama
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3549-3553
The retinoic acid receptor-related orphan receptor-gamma-t (RORγt) is the master transcription factor responsible for regulating the development and function of T-helper 17 (Th17) cells, which are related to the pathology of several autoimmune disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f021050106ded152726daddddc2fe5f
https://doi.org/10.1016/j.bmcl.2018.09.032
https://doi.org/10.1016/j.bmcl.2018.09.032
Publikováno v:
Biopharmaceutics & Drug Disposition. 37:373-378
1-Aminobenzotriazole (ABT) is a well-known in vivo nonspecific inhibitor of cytochrome P450 (CYP) enzymes. An effective dosing regimen of ABT for a multiple-administration study is needed to conduct pharmacological studies for proof-of-concept, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f49ba711b4d2a6e09fed5310d2767e50
https://doi.org/10.1002/bdd.2020
https://doi.org/10.1002/bdd.2020
Autor:
Ayahisa Watanabe, Hiroshi Kamimori, Reina Onishi, Mitsuaki Sekiguchi, Akira Kugimiya, Yoichiro Nihashi, Hiroki Kinouchi, Mado Nakajima
Publikováno v:
Analytical Sciences. 31:1255-1260
In the present study, we developed an assay to evaluate the kinetic binding properties of the unconjugated antisense oligonucleotide (ASO) and lipophilic and hydrophilic ligands conjugated ASOs to mouse and human serum albumin, and lipoproteins using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4a2588b92b9694e0c3bf667a6d9c92
https://doi.org/10.2116/analsci.31.1255
https://doi.org/10.2116/analsci.31.1255
Autor:
Kana Horiuchi, Ayahisa Watanabe, Tohru Mizutare, Takanobu Matsuzaki, Satoko Funaki, Hiroshi Hasegawa, Ken-ichi Nezasa, Shuichi Ohnishi, Sayaka Matsumoto
Publikováno v:
Journal of pharmaceutical sciences. 107(5)
Accurate prediction of human pharmacokinetics (PK) is important for the choice of promising compounds in humans. As the predictability of human PK by an empirical approach is low for drugs with species-specific PK, the utility of a physiologically ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e7ec52e5c2d64a2436f27e6b2a978a
https://pubmed.ncbi.nlm.nih.gov/29331382
https://pubmed.ncbi.nlm.nih.gov/29331382
Autor:
Akira Kugimiya, Takeshi Kasuya, Reina Onishi, Shinnichi Yokota, Mado Nakajima, Tatsuya Ikehara, Ayahisa Watanabe
Publikováno v:
Nucleic acid therapeutics. 27(4)
Cholesterol (Chol) conjugation to the 5' or 3' end of antisense oligonucleotide (ASO) enables delivery to the liver, and Chol conjugation at the gap region can also be expected to improve delivery to the liver. In this study, we synthesized ASOs bear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca3a710a2a5b4b3d486cd76721a86a7
https://pubmed.ncbi.nlm.nih.gov/28418770
https://pubmed.ncbi.nlm.nih.gov/28418770