Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Ayad A Jaffa"'
Autor:
Richard Saoud, Miran A Jaffa, Aida Habib, Jingfu Zhao, Moustafa Al Hariri, Rui Zhu, Anwarul Hasan, Fuad N Ziyadeh, Firas Kobeissy, Yehia Mechref, Ayad A Jaffa
Publikováno v:
Journal of Advanced Research, Vol 24, Iss , Pp 409-422 (2020)
Podocyte damage is one of the hallmarks of diabetic nephropathy leading to proteinuria and kidney damage. The underlying mechanisms of podocyte injury are not well defined. Bradykinin (BK) was shown to contribute to diabetic kidney disease. Here, we
Externí odkaz:
https://doaj.org/article/75d67ff9f0c04392bbdab7a1237abdd1
Autor:
Ibrahim A Ahmed, Miran A Jaffa, Mayssam Moussa, Duaa Hatem, Ghewa A El-Achkar, Rola Al Sayegh, Mia Karam, Eva Hamade, Aida Habib, Ayad A Jaffa
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The occurrence and persistence of hepatic injury which arises from cell death and inflammation result in liver disease. The processes that lead to liver injury progression and resolution are still not fully delineated. The plasma kallikrein-kinin sys
Externí odkaz:
https://doaj.org/article/4deb9a8e9ad54fe7a774b83a0215e5c3
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216908 (2019)
Bradykinin (BK) and thromboxane-A2 (TX-A2) are two vasoactive mediators that modulate vascular tone and inflammation via binding to their cognate "class A" G-protein coupled receptors (GPCRs), BK-B2 receptors (B2R) and TX-prostanoid receptors (TP), r
Externí odkaz:
https://doaj.org/article/f26598b48ced472f96f3e4ea4be93f99
Autor:
Ghewa A El-Achkar, May F Mrad, Charbel A Mouawad, Bassam Badran, Ayad A Jaffa, Roberto Motterlini, Eva Hamade, Aida Habib
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216405 (2019)
Statins exert pleiotropic and beneficial anti-inflammatory and antioxidant effects. We have previously reported that macrophages treated with statins increased the expression of heme oxygenase-1 (HO-1), an inducible anti-inflammatory and cytoprotecti
Externí odkaz:
https://doaj.org/article/ded259c09c424fb8a8e4bbc6cd78caa3
Autor:
Moustafa Al Hariri, Mohamad Elmedawar, Rui Zhu, Miran A Jaffa, Jingfu Zhao, Parvin Mirzaei, Adnan Ahmed, Firas Kobeissy, Fuad N Ziyadeh, Yehia Mechref, Ayad A Jaffa
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187752 (2017)
Diabetes is associated with a number of metabolic and cardiovascular risk factors that contribute to a high rate of microvascular and macrovascular complications. The risk factors and mechanisms that contribute to the development of micro- and macrov
Externí odkaz:
https://doaj.org/article/e1ad9303518e4a0cb26bdd4b02516088
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Endometrial cancer is one of the most common types of cancer that affects women’s reproductive system. The risk of endometrial cancer is associated with biologic, behavioral and social determinants of health (SDOH). The focus of
Externí odkaz:
https://doaj.org/article/d50de5346b7d4c5bbe504e0b2ad4e8fb
Autor:
Amaly Nokkari, Tarek H Mouhieddine, Muhieddine M Itani, Wassim Abou-Kheir, Georges Daoud, Rui Zhu, Yehia Mechref, Jihane Soueid, Moustafa Al Hariri, Stefania Mondello, Ayad A Jaffa, Firas Kobeissy
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136345 (2015)
Externí odkaz:
https://doaj.org/article/0538df924fa244a19d2b41dd97817d09
Autor:
Amaly Nokkari, Tarek H Mouhieddine, Muhieddine M Itani, Wassim Abou-Kheir, Georges Daoud, Rui Zhu, Yehia Mechref, Jihane Soueid, Moustafa Al Hariri, Stefania Mondello, Ayad A Jaffa, Firas Kobeissy
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128601 (2015)
Traumatic Brain Injury (TBI) is the result of a mechanical impact on the brain provoking mild, moderate or severe symptoms. It is acknowledged that TBI leads to apoptotic and necrotic cell death; however, the exact mechanism by which brain trauma lea
Externí odkaz:
https://doaj.org/article/6872532b9e2e4a278800e58fd36916c0
Autor:
VICTORIA VELARDE, PAULA M DE LA CERDA, CLAUDIA DUARTE, FRANCISCA ARANCIBIA, EDUARDO ABBOTT, ALEJANDRO GONZÁLEZ, FRANCESCA MORENO, AYAD A JAFFA
Publikováno v:
Biological Research, Vol 37, Iss 3, Pp 419-430 (2004)
In addition to the induction of cell proliferation and migration, bradykinin (BK) can increase c-fos mRNA expression, activate ERK 1/2 and generate reactive oxygen species (ROS) in vascular smooth muscle cells (VSMC). It is not known, however, whethe
Externí odkaz:
https://doaj.org/article/2aed0f5adfd94dfe9438a6d583e0c6d2
Autor:
Mia Karam, Marwa Faraj, Miran A. Jaffa, Joseph Jelwan, Kawthar Sharaf Aldeen, Nadine Hassan, Rami Mhanna, Ayad A. Jaffa
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116750- (2024)
Connective tissue growth factor (CTGF) holds great promise for enhancing the wound healing process; however, its clinical application is hindered by its low stability and the challenge of maintaining its effective concentration at the wound site. Her
Externí odkaz:
https://doaj.org/article/f1145e957c5a471fbecc32c2d4fde3d0