Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Aya Ushio"'
Autor:
Aya Ushio, Mami Matsuda-Lennikov, Felix Kalle-Youngoue, Akihide Shimizu, Abdalla Abdelmaksoud, Michael C. Kelly, Naozumi Ishimaru, Yousuke Takahama
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114072- (2024)
Summary: Medullary thymic epithelial cells (mTECs) are essential for the establishment of self-tolerance in T cells. Promiscuous gene expression by a subpopulation of mTECs regulated by the nuclear protein Aire contributes to the display of self-geno
Externí odkaz:
https://doaj.org/article/7078fd472f85403aa1d52ace8be585dd
Autor:
Mami Sato-Fukuba, Rieko Arakaki, Aya Ushio, Kunihiro Otsuka, Ruka Nagao, Shigefumi Matsuzawa, Hiroaki Tawara, Takaaki Tsunematsu, Naozumi Ishimaru
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPrimary Sjögren’s syndrome (pSS) is a systemic autoimmune disease that affects the function of exocrine glands, such as the lacrimal and the salivary glands. Extraglandular lesions and malignant lymphoma also occur during the progressi
Externí odkaz:
https://doaj.org/article/355d5854dc5a47e19901f09c97191eba
Autor:
Mami Sato, Rieko Arakaki, Hiroaki Tawara, Ruka Nagao, Hidetaka Tanaka, Kai Tamura, Yuhki Kawahito, Kunihiro Otsuka, Aya Ushio, Takaaki Tsunematsu, Naozumi Ishimaru
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
ObjectiveInnate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1, ILC2, lymphoid tissue-inducer (LTi) cells, and ILC3 cell, play a key role in various immune responses. Primary Sjögren’s syndrome (pSS) is an autoimmune disease char
Externí odkaz:
https://doaj.org/article/56a4f49bc8b64752b478b705a065f41d
Autor:
Aya Ushio, Rieko Arakaki, Kunihiro Otsuka, Akiko Yamada, Takaaki Tsunematsu, Yasusei Kudo, Keiko Aota, Masayuki Azuma, Naozumi Ishimaru
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Macrophages (MΦs) are critical regulators of immune response and serve as a link between innate and acquired immunity. The precise mechanism of involvement of tissue-resident MΦs in the pathogenesis of autoimmune diseases is not clear. Here, using
Externí odkaz:
https://doaj.org/article/ad9ce62163654ed88b688092af19665b
Autor:
Kunihiro Otsuka, Koichi Yamada, Yuhji Taquahashi, Rieko Arakaki, Aya Ushio, Masako Saito, Akiko Yamada, Takaaki Tsunematsu, Yasusei Kudo, Jun Kanno, Naozumi Ishimaru
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205702 (2018)
BACKGROUND:Nanomaterials are widely used in various fields. Although the toxicity of carbon nanotubes (CNTs) in pulmonary tissues has been demonstrated, the toxicological effect of CNTs on the immune system in the lung remains unclear. METHODS AND FI
Externí odkaz:
https://doaj.org/article/03c182b5ba154f86b4ee62d2a6cd35e7
Autor:
Mami Sato-Fukuba, Rieko Arakaki, Aya Ushio, Kunihiro Otsuka, Ruka Nagao, Shigefumi Matsuzawa, Hiroaki Tawara, Takaaki Tsunematsu, Naozumi Ishimaru
Publikováno v:
Frontiers in Immunology; 2023, p1-15, 15p
Autor:
Mai Tanabe, Yasuhiro Mitsui, Kiyoe Kurahashi, Aya Ushio, Shinji Kitamura, Koichi Okamoto, Yasushi Sato, Naoki Muguruma, Yasusei Kudo, Tetsuji Takayama
Publikováno v:
Nihon Naika Gakkai Zasshi. 110:289-294
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::389f4aae7ff0c1de243c39da8356428b
https://doi.org/10.2169/naika.110.289
https://doi.org/10.2169/naika.110.289
Autor:
Mami Sato, Satoru Morishita, Naozumi Ishimaru, Yasusei Kudo, Yoshitaka Nakamura, Noriyuki Monoi, Riho Tateyama, Rieko Arakaki, Satoru Kisoda, Kanako Yuyama, Aya Ushio
Publikováno v:
Journal of Oral Biosciences. 61:179-182
Objectives Sicca syndrome is characterized by dry mouth and eyes and results in a reduction of the patient's quality of life. Various natural plants, including certain herbs, have long been employed to alleviate such symptoms. Rooibos grown in South
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0053fa1805f334ce4cf269bdbeeddf
https://doi.org/10.1016/j.job.2019.06.001
https://doi.org/10.1016/j.job.2019.06.001
Autor:
Alison Jacques, Margaret C. Cam, Naozumi Ishimaru, Michael C. Kelly, Kensuke Takada, Da Yin, Melina Frantzeskakis, Izumi Ohigashi, Parirokh Awasthi, Sayumi Fujimori, Yousuke Takahama, Aya Ushio, Fusano Yamashita
Publikováno v:
The Journal of Experimental Medicine
The thymoproteasome expressed in thymic cortical epithelium optimizes the generation of CD8+ T cells. This study reveals that the thymoproteasome hardwires the TCR repertoire of CD8+ T cells with cortical positive selection independent of thymic nega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b76ae8b8b0ab86beaf0331b2c458e72
https://doi.org/10.1084/jem.20201904
https://doi.org/10.1084/jem.20201904
Autor:
Naozumi Ishimaru, Akiko Yamada, Aya Ushio, Masako Saito, Kunihiro Otsuka, Rieko Arakaki, Yasusei Kudo
Publikováno v:
Current Rheumatology Reviews
Sjogren’s syndrome (SS) is a T cell-mediated autoimmune disease of the systemic exocrine glands, such as salivary and lacrimal glands. A variety of T-cell subpopulations maintain immune tolerance in the thymus and periphery through complex immune r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a105a81a55d8c6312edba8ce10e2019
https://doi.org/10.2174/1573397113666170125122858
https://doi.org/10.2174/1573397113666170125122858