Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Aya Uchiyama"'
Autor:
Mitsutake Yano, Kaei Nasu, Masanori Yasuda, Tomomi Katoh, Masahiro Kagabu, Hisanori Kobara, Motoki Matsuura, Osamu Tokuyama, Takaharu Yamawaki, Senn Wakahashi, Tomoko Noguchi, Kaoruko Mizuno, Keiji Shitsukawa, Yoshimasa Onohara, Takashi Nakabori, Aki Miyasaka, Takehiro Nakao, Tatsuya Matsunaga, Yusuke Kunimi, Manabu Sakurai, Aya Uchiyama, Ryoji Itoh, Nobuyuki Ohike, Takashi Hirakawa, Tadashi Watanabe, Koji Nishino, Takashi Motohashi, Kimihiko Ito
Publikováno v:
Melanoma Research. 32:150-158
The objective of this study was to propose prognostic factors and optimal treatment strategies by analyzing the clinicopathological features and programmed death-ligand 1 (PD-L1) expression. We analyzed 31 patients diagnosed with uterine or ovarian m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da4ad6346953e6b454330bd48cc4747
https://doi.org/10.1097/cmr.0000000000000811
https://doi.org/10.1097/cmr.0000000000000811
Autor:
Kazuyasu Fujii, Naoya Yamazaki, Yasuhiro Fujisawa, Tatsuya Takenouchi, Ryuhei Okuyama, Kaori Sakaizawa, Satoshi Fukushima, Jiro Uehara, Shigeto Matsushita, Aya Uchiyama, Dai Ogata, Hisashi Uhara, Takamichi Ito, Atsuko Ashida, Yoshitsugu Shibayama, Naohito Hatta
Publikováno v:
Journal of Dermatological Science. 80:33-37
Background The importance of the genetic background of melanoma cells to the individual susceptibility to treatment has become apparent. In Caucasians, BRAF mutations are frequently detected in lesions on the skin of younger patients compared to NRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2823e22f2531ffa5340d795535d2d4f0
https://doi.org/10.1016/j.jdermsci.2015.07.012
https://doi.org/10.1016/j.jdermsci.2015.07.012
Autor:
Atsuko Ashida, Yasufumi Goto, Hisashi Uhara, Ryuhei Okuyama, Yukiko Kiniwa, Yuko Takazawa, Aya Uchiyama, Eisaku Ogawa
Publikováno v:
The Tohoku Journal of Experimental Medicine. 234:57-65
Immune cell Toll-like receptors (TLRs) recognize conserved microbial components, leading to immune and inflammatory responses. However, TLRs are also expressed in cancer cells, including melanoma cells, which express TLR2-4. TLR4 ligands have receive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6b7205eba055c1bfecfb8b9039a09b
https://doi.org/10.1620/tjem.234.57
https://doi.org/10.1620/tjem.234.57
Autor:
Hisashi Uhara, Yukiko Kiniwa, Aya Uchiyama, Koichi Hayashi, Hiroshi Koga, Atsuko Ashida, Eisaku Ogawa, Ryuhei Uchiyama, Ryuhei Okuyama
Publikováno v:
International Journal of Clinical Oncology. 19:544-548
Characterization of the MAPK signaling pathway in melanoma has led to the development of MEK inhibitors for the treatment of NRAS-mutated melanoma. The success of molecular-targeted therapies underscores the need to identify mutations in target genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f597997900e83836c1924b1af4eb621
https://doi.org/10.1007/s10147-013-0573-2
https://doi.org/10.1007/s10147-013-0573-2
Autor:
Shinji Shimada, Ryuhei Okuyama, Kaori Sakaizawa, Soldano Ferrone, Yasufumi Goto, Yukiko Kiniwa, Hisashi Uhara, Minoru Takata, Kazutoshi Harada, Aya Uchiyama, Toshiaki Saida
Publikováno v:
British Journal of Cancer
信州大学博士（医学）・学位論文・平成25年3月31日授与（甲第945号）・境澤 香里
BACKGROUND: The availability of molecular-targeted therapies for the treatment of melanoma has emphasised the need to identify mutations
BACKGROUND: The availability of molecular-targeted therapies for the treatment of melanoma has emphasised the need to identify mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfaba4515c3975582e350ff1f41df38e
https://doi.org/10.1038/bjc.2012.12
https://doi.org/10.1038/bjc.2012.12
Autor:
Hiroshi Murata, Yasufumi Goto, Toshiaki Saida, J. Lin, Aya Uchiyama, Minoru Takata, Kaori Sakaizawa
Publikováno v:
British Journal of Cancer
Among the several genetic alterations governing melanoma initiation and progression so far identified, the serine/threonine-specific protein kinase BRAF is thought to be a key player because it is activated by somatic mutations in 50–70% of cutaneo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29413a236d3f7eaa96ea0afe10e223d5
http://europepmc.org/articles/PMC3049568
http://europepmc.org/articles/PMC3049568
Autor:
Susumu Tanimura, Toshiaki Sakamoto, Takumi Kawabata, Michiaki Kohno, Kazushi Watanabe, Aya Uchiyama, Kei-ichi Ozaki
Publikováno v:
Clinical Cancer Research. 16:1170-1178
Purpose: The extracellular signal-regulated kinase (ERK) pathway is upregulated in human cancers and represents a target for mechanism-based approaches to cancer treatment. However, specific blockade of the ERK pathway alone induces mostly cytostatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b542f1fdce1e716e1bd827403a2116
https://doi.org/10.1158/1078-0432.ccr-09-2482
https://doi.org/10.1158/1078-0432.ccr-09-2482
Autor:
Kazuo Koyanagi, Donald L. Morton, Yutaka Kawakami, Xing Ye, Minoru Takata, Linhda Nguyen, Norihiko Narita, Tung Nguyen, Dave S.B. Hoon, Yasufumi Goto, Aya Uchiyama
Publikováno v:
Journal of Investigative Dermatology. 130(1):221-229
Fatty acid-binding protein-7 (FABP7) has been shown to be expressed in cutaneous melanoma; however, its role in tumor progression is unclear. Expression of FABP7 was assessed during melanoma progression through assessment of various clinicopathology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4732a1531685d0a569e6c2e4359e87
Autor:
Yuko Takazawa, Koichi Hayashi, Eisaku Ogawa, Ryuhei Uchiyama, Hisashi Uhara, Aya Uchiyama, Ryuhei Okuyama, Yukiko Kiniwa, Atsuko Ashida, Hiroshi Koga
Publikováno v:
Journal of dermatological science. 73(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a4371a4ed96b88e1a998f5fb93e404
https://pubmed.ncbi.nlm.nih.gov/24169492
https://pubmed.ncbi.nlm.nih.gov/24169492
Autor:
Eisaku Ogawa, Yasufumi Goto, Hisashi Uhara, Atsuko Ashida, Aya Uchiyama, Yukiko Kiniwa, Ryuhei Okuyama, Yuko Takazawa
Publikováno v:
Journal of Dermatological Science. 84:e85
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5348f8e4f6faba03116b0517a1c527d
https://doi.org/10.1016/j.jdermsci.2016.08.260
https://doi.org/10.1016/j.jdermsci.2016.08.260