Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists

Autor: Ayana Yoshihara, Haru Kawasaki, Hiroyuki Masuno, Koki Takada, Nobutaka Numoto, Nobutoshi Ito, Naoya Hirata, Yasunari Kanda, Michiyasu Ishizawa, Makoto Makishima, Hiroyuki Kagechika, Aya Tanatani

Publikováno v: Biomolecules, Vol 12, Iss 1, p 130 (2022)

1α,25-Dihydroxyvitamin D3 [1α,25(OH)2D3, 1] is an active form of vitamin D3 and regulates various biological phenomena, including calcium and phosphate homeostasis, bone metabolism, and immune response via binding to and activation of vitamin D rec

Externí odkaz: https://doaj.org/article/b359ac1d26e946909bc654659990f0b5

A Novel Lithocholic Acid Derivative Upregulates Detoxification-Related Genes in Human Induced Pluripotent Stem Cell-Derived Intestinal Organoids

Autor: Shigeru Yamada, Hiroyuki Masuno, Hiroyuki Kagechika, Aya Tanatani, Yasunari Kanda

Publikováno v: Biologicalpharmaceutical bulletin. 45(11)

Vitamin D is a fat-soluble micronutrient that plays essential roles in a range of biological processes, including cell proliferation, inflammation, and metabolism. In this study, we investigated the effects of a novel synthetic lithocholic acid deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5d74f03ec0215149382078b18107a8
https://pubmed.ncbi.nlm.nih.gov/36328508

Accessing Improbable Foldamer Shapes with Strained Macrocycles

Autor: Masatoshi Kawahata, Aya Tanatani, Vojislava Pophristic, Yann Ferrand, Kosuke Katagiri, Ko Urushibara, Ryan D'Elia, Ivan Huc, Zhiwei Liu, Estelle Morvan

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, In press, ⟨10.1002/chem.202101201⟩

The alkylation of some secondary amide functions with a dimethoxybenzyl (DMB) group in oligomers of 8‐amino‐2‐quinolinecarboxylic acid destabilizes the otherwise favored helical conformations, and allows for cyclization to take place. A cyclic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf43ce2ddf132521153d63dd965367e
http://europepmc.org/articles/PMC8453500

Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists

Autor: Ayana Yoshihara, Keiko Yamamoto, Hiroyuki Kagechika, Aya Tanatani, Nobutoshi Ito, Haru Kawasaki, Harue Sasaki, Nobutaka Numoto, Naoya Hirata, Hiroyuki Masuno, Emiko Kawachi, Yasunari Kanda, Hiroaki Ishida

Publikováno v: Journal of Medicinal Chemistry. 64:516-526

Lithocholic acid (2) was identified as a second endogenous ligand of vitamin D receptor (VDR), though its activity is very weak. In this study, we designed novel lithocholic acid derivatives based on the crystal structure of VDR-ligand-binding domain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52bf619db2b09df7143c4b0ba3feb210
https://doi.org/10.1021/acs.jmedchem.0c01420

Spontaneous chiral resolution of N,N′-diarylsquaramides: Formation of various types of one-handed helical networks during crystallization

Autor: Hiroyuki Kagechika, Kosuke Katagiri, Aya Tanatani, Hyuma Masu, Midori Kanda, Ko Urushibara, Shinya Fujii, Soyoung Park, Isao Azumaya

Publikováno v: Tetrahedron. 75:2771-2777

N,N′-Bis(ortho-substituted phenyl)squaramides afforded chiral crystals, in which squaramide molecules are arranged in one-handed helical networks, upon simple recrystallization. Three types of crystals with different helices were obtained, dependin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ff6732010956009e2b62c292c5260fa
https://doi.org/10.1016/j.tet.2019.03.049