Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Aya Shoda"'
Autor:
Jun-ichi Eguchi, Shinsuke Hiki, Masatake Fujimura, Satoshi Yuki, Shinji Sunada, Tokushi Hanano, Masahiro Okuyama, Fumiaki Uehara, Toshiyuki Kohara, Hiroshi Tanaka, Keiichi Aritomo, Susumu Tsuchiya, Ken-Ichi Saito, Kenji Fukunaga, Kazutoshi Watanabe, Shoichi Asano, Koichi Yamakoshi, Hiroshi Baba, Shinji Tanaka, Takashi Horikawa, Yoshihiro Usui, Aya Shoda, Akiko Mori, Keiji Yamagami
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6933-6937
A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3β (GSK-3β). We found 21, 29 and 30 to possess potent in vitro GSK-3β inhibitory activity with g
Autor:
Ryoichi Ando, Satoshi Yuki, Takuro Niwa, Takahide Kaji, Hiroaki Ueno, Hideo Kubodera, Ken-Ichi Saito, Jun-ichi Eguchi, Kenji Fukunaga, Shoichi Asano, Fumiaki Uehara, Keiichi Aritomo, Shinji Sunada, Aya Shoda, Masaki Shinoda, Shinji Tanaka, Yukimi Yoneyama, Kazutoshi Watanabe
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(24)
The discovery of a series of 6-(4-pyridyl)pyrimidin-4(3H)-ones derived from a hit compound with low molecular weight and sufficient chemical space is reported. Transformation of substituents led to subnanomolar potent inhibitors with in vivo tau phos