Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Aya Masaoka"'
Autor:
Aya Masaoka, Natalie R Gassman, Julie K Horton, Padmini S Kedar, Kristine L Witt, Cheryl A Hobbs, Grace E Kissling, Keizo Tano, Kenjiro Asagoshi, Samuel H Wilson
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66801 (2013)
The breast cancer 1 (BRCA1) protein is a tumor suppressor playing roles in DNA repair and cell cycle regulation. Studies of DNA repair functions of BRCA1 have focused on double-strand break (DSB) repair pathways and have recently included base excisi
Externí odkaz:
https://doaj.org/article/8c8ec1591f79421093a6465237cd408a
Autor:
Akira Fujimori, Jac A. Nickoloff, Shigeaki Sunada, Huizi Keiko Li, Younghyun Lee, Hirokazu Hirakawa, Aya Masaoka, Ryuichi Okayasu
Publikováno v:
Radiotherapy and Oncology. 121:162-168
Background and purpose PU-H71 is a purine-scaffold Hsp90 inhibitor developed to overcome limitations of conventional Hsp90 inhibitors. This study was designed to investigate the combined effect of PU-H71 and heavy ion irradiation on human tumor and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acc8c3332997b32bdfd9ec7250b5801
https://doi.org/10.1016/j.radonc.2016.08.029
https://doi.org/10.1016/j.radonc.2016.08.029
Autor:
Ryuichi Okayasu, Akira Fujimori, Hirokazu Hirakawa, Hiroshi Fujisawa, Aya Masaoka, Ryoichi Hirayama, Miho Noguchi, Momoko Takahashi
Publikováno v:
Cancer Medicine
Hsp90 inhibitors have become well-studied antitumor agents for their selective property against tumors versus normal cells. The combined treatment of Hsp90 inhibitor and conventional photon radiation also showed more effective tumor growth delay than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de91a40c808e228ee589111f4fd31d0e
https://repo.qst.go.jp/records/47077
https://repo.qst.go.jp/records/47077
Autor:
Samuel H. Wilson, Aya Masaoka, Natalie R. Gassman, Julie K. Horton, Padmini S. Kedar, Esther W. Hou, Michael Bustin, Rajendra Prasad
Publikováno v:
Journal of Biological Chemistry. 287:27648-27658
In mammalian cells, the nucleosome-binding protein HMGN1 (high mobility group N1) affects the structure and function of chromatin and plays a role in repair of damaged DNA. HMGN1 affects the interaction of DNA repair factors with chromatin and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6737275f2e3d551e41754b121343839
https://doi.org/10.1074/jbc.m112.370759
https://doi.org/10.1074/jbc.m112.370759
Publikováno v:
DNA Repair. 8:1290-1299
To examine base excision repair (BER) capacity in the context of living cells, we developed and applied a plasmid-based reporter assay. Non-replicating plasmids containing unique DNA base lesions were designed to express luciferase only after lesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f6f59da66419f216ea2e914df6a17a
https://doi.org/10.1016/j.dnarep.2009.08.004
https://doi.org/10.1016/j.dnarep.2009.08.004
Autor:
Atsushi Katafuchi, Toshiaki Nakano, Hiroshi Ide, Fumio Hanaoka, Aya Masaoka, Shigenori Iwai, Hiroaki Terato
Publikováno v:
Journal of Biological Chemistry. 279:14464-14471
In human cells, oxidative pyrimidine lesions are restored by the base excision repair pathway initiated by homologues of Endo III (hNTH1) and Endo VIII (hNEIL1 and hNEIL2). In this study we have quantitatively analyzed and compared their activity tow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1335f325e5bdf07d55cfac11036ff8
https://doi.org/10.1074/jbc.m400393200
https://doi.org/10.1074/jbc.m400393200
Autor:
Mayumi Matsubara, Rei Hasegawa, Aya Masaoka, Hiroshi Ide, Hiroaki Terato, and Akira Matsuda, Yoshihiko Ohyama, Tamon Tanaka, Naoko Karino, Satofumi Kurisu
Publikováno v:
Biochemistry. 42:5003-5012
In the accompanying paper [Matsubara, M., et al. (2003) Biochemistry 42, 4993-5002], we have partially purified and characterized rat 5-formyluracil (fU)-DNA glycosylase (FDG). Several lines of evidence have indicated that FDG is a rat homologue of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6a75e7a4976eecb651174166c14a4b
https://doi.org/10.1021/bi0273213
https://doi.org/10.1021/bi0273213
Autor:
Takayuki Miyano, Hiroshi Ide, Yoshihiko Ohyama, Nagisa Kato, Tamon Tanaka, Shigenori Iwai, Hiroaki Terato, Mayumi Matsubara, Aya Masaoka
Publikováno v:
Biochemistry. 42:4993-5002
5-Formyluracil (fU) is a major oxidative thymine lesion produced by reactive oxygen species and exhibits genotoxic and cytotoxic effects via several mechanisms. In the present study, we have searched for and characterized mammalian fU-DNA glycosylase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e3c2ddc0aa0c6881d173ebf2d519fc
https://doi.org/10.1021/bi027322v
https://doi.org/10.1021/bi027322v
Publikováno v:
Journal of Biological Chemistry. 276:16501-16510
5-Formyluracil (fU) is a major oxidative thymine lesion generated by ionizing radiation and reactive oxygen species. In the present study, we have assessed the influence of fU on DNA replication to elucidate its genotoxic potential. Oligonucleotide t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5e278a4c214237d69544daec49f5c7
https://doi.org/10.1074/jbc.m008598200
https://doi.org/10.1074/jbc.m008598200
Publikováno v:
Journal of Biological Chemistry. 274:25136-25143
5-Formyluracil (fU) is a major thymine lesion produced by reactive oxygen radicals and photosensitized oxidation. We have previously shown that fU is a potentially mutagenic lesion due to its elevated frequency to mispair with guanine. Therefore, fU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86e1935edfd8e7532421836da71f9c48
https://doi.org/10.1074/jbc.274.35.25136
https://doi.org/10.1074/jbc.274.35.25136