Výsledky vyhledávání - "Aya M. Almatary"

Akademický článek

Identification of Benzothiazoles Bearing 1,3,4-Thiadiazole as Antiproliferative Hybrids Targeting VEGFR-2 and BRAF Kinase: Design, Synthesis, BIO Evaluation and In Silico Study

Autor: Wafaa A. Ewes, Samar S. Tawfik, Aya M. Almatary, Mashooq Ahmad Bhat, Hamed W. El-Shafey, Ahmed A. B. Mohamed, Abdullah Haikal, Mohammed A. El-Magd, Abdullah A. Elgazar, Marwa Balaha, Abdelrahman Hamdi

Publikováno v: Molecules, Vol 29, Iss 13, p 3186 (2024)

Cancer remains a leading cause of death worldwide, often resulting from uncontrolled growth in various organs. Protein kinase inhibitors represent an important class of targeted cancer therapies. Recently, the kinases BRAF and VEGFR-2 have shown syne

Externí odkaz: https://doaj.org/article/a4915b3b03014f48954ca3fc6a3d2663

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Design, synthesis, and molecular modeling of heterocyclic bioisostere as potent PDE4 inhibitors

Autor: Mohammad A. Elmorsy, Walaa M. El Husseiny, Aya M. Almatary, Magda A.-A. El-Sayed, Khalid B. Selim

Publikováno v: Archiv der Pharmazie. 351:1700403

A new hybrid template was designed by combining the structural features of phosphodiesterase 4 (PDE4) inhibitors with several heterocyclic moieties which present an integral part in the skeleton of many apoptotic agents. Thirteen compounds of the syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a60a967c2498eac358e4cb35d52cf35
https://doi.org/10.1002/ardp.201700403

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