Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Aya Ludin"'
Autor:
Tomer Itkin, Shiri Gur-Cohen, Joel A. Spencer, Amir Schajnovitz, Saravana K. Ramasamy, Anjali P. Kusumbe, Guy Ledergor, Yookyung Jung, Idan Milo, Michael G. Poulos, Alexander Kalinkovich, Aya Ludin, Karin Golan, Eman Khatib, Anju Kumari, Orit Kollet, Guy Shakhar, Jason M. Butler, Shahin Rafii, Ralf H. Adams, David T. Scadden, Charles P. Lin, Tsvee Lapidot
Publikováno v:
Nature. 532:323-328
Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance. However, it is not clear how BMECs balance these dual roles, and whether th
Autor:
Aya Ludin, Leonard I. Zon
Inhibiting the protein PD-1 can activate T cells that trigger immune responses against tumour cells. But it emerges that, in mice, this immunotherapy exacerbates a cancer that involves the T cells themselves. See Letter p.121 PD-1 functions as an inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a568d73f2fddbaa7b315358fcdc3ce6
https://europepmc.org/articles/PMC6136420/
https://europepmc.org/articles/PMC6136420/
Autor:
Ayelet Erez, Elisabeth Niemeyer, Sagarika Chakrabarty, Guy Ledergor, Ziv Porat, Orit Kollet, Irit Sagi, Wolfram Ruf, Claudine Graf, Shiri Gur-Cohen, Alexander Kalinkovich, Charles T. Esmon, Tsvee Lapidot, Eitan Wong, Tomer Itkin, Aya Ludin, Karin Golan
Publikováno v:
Nature Medicine. 21:1307-1317
Retention of long-term repopulating hematopoietic stem cells (LT-HSCs) in the bone marrow is essential for hematopoiesis and for protection from myelotoxic injury. We report that signaling cascades that are traditionally viewed as coagulation related
Autor:
Biana Bernshtein, Irit Sagi, Orit Kollet, Andrzej Ciechanowicz, John E. Dick, Eman Khatib-Massalha, Sylwia Rzeszotek, Eugenia Flores-Figueroa, Shiri Gur-Cohen, Francesca Avemaria, Tsvee Lapidot, Mayla Bertagna, Aya Ludin-Tal, Mohana Devi Subramaniam, Nathali Kaushansky, Regina P. Markus, Hassan Massalha, Tevie Mehlman, Mariusz Z. Ratajczak, Karin Golan, Simón Méndez-Ferrer, Anju Kumari, Tomer Itkin, Andrés García-García, Zulma S. Ferreira, Hui Cheng, Tomasz Janus, Stephanie Z. Xie, Ekaterina Petrovich-Kopitman, Alexander Brandis, Tao Cheng, Suditi Bhattacharya
Publikováno v:
Cell Stem Cell
Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic stem cells (LT-HSCs), with intensive daily production of mature leukocytes a
Autor:
Chiara Medaglia, Shiri Gur-Cohen, Kerstin B. Kaufmann, Tsvee Lapidot, Karin Golan, Orit Kollet, Tomer Itkin, Guy Ledergor, Aya Ludin, Xin-Jiang Lu
Publikováno v:
Antioxidants & Redox Signaling. 21:1605-1619
Significance: Blood forming, hematopoietic stem cells (HSCs) mostly reside in the bone marrow in a quiescent, nonmotile state via adhesion interactions with stromal cells and macrophages. Quiescent, proliferating, and differentiating stem cells have
Autor:
Gabriele D'Uva, Karin Golan, Orit Kollet, Giulia Caglio, Adi Neufeld-Cohen, Aya Ludin, Shiri Gur-Cohen, Alexander Kalinkovich, Tsvee Lapidot, Kfir Lapid, Chiara Medaglia, Alon Chen, Elias Shezen, Diana Varol, Jonathan Canaani, Yaron Vagima, Tomer Itkin
Publikováno v:
Leukemia. 27:2006-2015
The role of corticosterone (Cort), the immune system's major stress hormone, in the regulation of hematopoietic stem and progenitor cells (HSPCs) and their dynamic bone marrow (BM) microenvironment is currently unknown. We report that corticotropin-r
Autor:
Orit Kollet, Jonathan Canaani, Eran Hornstein, Elias Shezen, Aya Ludin, Thorsten Berg, Ben Gradus, Wanda Piacibello, Yossi Ovadya, Amir Schajnovitz, Grigori Enikolopov, Shiri Gur-Cohen, Alexander Kalinkovich, Tsvee Lapidot, Tomer Itkin, Douglas J. Coffin
Publikováno v:
Blood. 120:1843-1855
Cytokine-induced expansion of hematopoietic stem and progenitor cells (HSPCs) is not fully understood. In the present study, we show that whereas steady-state hematopoiesis is normal in basic fibroblast growth factor (FGF-2)–knockout mice, parathyr
Publikováno v:
FEBS Journal. 278:4150-4165
Mobilization of hematopoietic stem and progenitor cells (HSPCs) from the bone marrow to the peripheral blood is utilized in clinical HSPC transplantation protocols. Retention of HSPCs in the bone marrow is determined by relationships between the chem
Autor:
Tomer Itkin, Orit Kollet, Tsvee Lapidot, Gabriele D'Uva, Arnon Nagler, Dror Cohen, Alexander Kalinkovich, Rony Seger, Ziv Shulman, Amir Schajnovitz, Aya Ludin, Karin Golan, Abraham Avigdor
Publikováno v:
Nature Immunology. 12:391-398
The chemokine CXCL12 is essential for the function of hematopoietic stem and progenitor cells. Here we report that secretion of functional CXCL12 from human bone marrow stromal cells (BMSCs) was a cell contact-dependent event mediated by connexin-43
Autor:
Menachem Rubinstein, Neta Netzer, Arnon Nagler, Herzel Ben-Hur, Alexander Kalinkovich, Shoham Shivtiel, Tsvee Lapidot, Asaf Spiegel, Aya Ludin, Igor B. Resnick, Yaara Azaria, Polina Goichberg, Izhar Hardan
Publikováno v:
Nature Immunology. 8:1123-1131
Catecholamines are important regulators of homeostasis, yet their functions in hematopoiesis are poorly understood. Here we report that immature human CD34+ cells dynamically expressed dopamine and beta2-adrenergic receptors, with higher expression i