Výsledky vyhledávání - "Aya Kawanami"

Loss of DARPP-32 and calbindin in multiple system atrophy

Autor: Hideki Mochizuki, Jiro Takano, Makoto Saegusa, Yasuto Nakata, Masahiko Takada, Yoshikuni Mizuno, Takaomi C. Saido, Tetsuo Mikami, Tomoko Nihira, Aya Kawanami, Makiko Nagai, Hideki Hayakawa, Mieko Ogino, Junichi Hamada, Kazutoshi Nishiyama

Publikováno v: Journal of Neural Transmission

We evaluated the immunohistochemical intensities of α-synuclein, phosphorylated α-synuclein (p-syn), dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), calbindin-D 28k, calpain-cleaved carboxy-terminal 150-kDa spectrin fragment, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d169aa6feca76d562cadb3200cf1b17
http://europepmc.org/articles/PMC3834182

Zobrazit plný text záznamu

Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal

Autor: Shunichi Murakami, Arjun S. Sebastian, Aya Kawanami, Takehiko Matsushita, Gary E. Landreth, Susan Mackem

Publikováno v: Journal of Orthopaedic Research. 29:375-379

Activating mutations in FGFR3 cause the most common forms of human dwarfism: achondroplasia and thanatophoric dysplasia. In mouse models of achondroplasia, recent studies have implicated the ERK MAPK pathway, a pathway activated by FGFR3, in creating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279c85a7194eac899207a45dc07f2d08
https://doi.org/10.1002/jor.21262

Zobrazit plný text záznamu

Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Play Essential Roles in Osteoblast Differentiation and in Supporting Osteoclastogenesis

Autor: Aya Kawanami, Gary E. Landreth, Gener Balmes, Yuk Yu Chan, Takehiko Matsushita, Shunichi Murakami

Publikováno v: Molecular and Cellular Biology. 29:5843-5857

Osteoblasts and chondrocytes arise from common osteo-chondroprogenitor cells. We show here that inactivation of ERK1 and ERK2 in osteo-chondroprogenitor cells causes a block in osteoblast differentiation and leads to ectopic chondrogenic differentiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28edb2706a0c00816f141f614441a2e7
https://doi.org/10.1128/mcb.01549-08

Zobrazit plný text záznamu

Autonomous turning of cerebellar granule cells in vitro by intrinsic programs

Autor: Aya Kawanami, Tatsuro Kumada, Yulan Jiang, D. Bryant Cameron, Hitoshi Komuro

Publikováno v: Developmental Biology. 326:237-249

External guidance cues play a role in controlling neuronal cell turning in the developing brain, but little is known about whether intrinsic programs are also involved in controlling the turning. In this study, we examined whether granule cells under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de33bada54be213d3e14a42824b303a
https://doi.org/10.1016/j.ydbio.2008.11.012

Zobrazit plný text záznamu

FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway

Autor: Hulya Bukulmez, David Givol, Pavel Krejci, William R. Wilcox, Takehiko Matsushita, Kazuyuki Otani, Shunichi Murakami, Isakichi Yamaura, Pertchoui B. Mekikian, Yuk Yu Chan, Aya Kawanami, Gener Balmes, Matthew L. Warman

Publikováno v: Human Molecular Genetics. 18:227-240

Activating mutations in FGFR3 cause achondroplasia and thanatophoric dysplasia, the most common human skeletal dysplasias. In these disorders, spinal canal and foramen magnum stenosis can cause serious neurologic complications. Here, we provide evide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f978a1df803437a89b565bfa6be41bd7
https://doi.org/10.1093/hmg/ddn339

Zobrazit plný text záznamu

Prx1 and 3.2kb Col1a1 promoters target distinct bone cell populations in transgenic mice

Autor: Zhufeng Ouyang, Patrick Leahy, Aya Kawanami, Shunichi Murakami, Zhijun Chen, Masakazu Ishikawa, Xiuzhen Yue, Edward M. Greenfield

Publikováno v: Bone. 58

Bones consist of a number of cell types including osteoblasts and their precursor cells at various stages of differentiation. To analyze cellular organization within the bone, we generated Col1a1CreER-DsRed transgenic mice that express, in osteoblast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a81698cad1ac7197fc1dc88fe9c549
https://pubmed.ncbi.nlm.nih.gov/24513582

Zobrazit plný text záznamu

Mice expressing GFP and CreER in osteochondro progenitor cells in the periosteum

Autor: Aya Kawanami, Shunichi Murakami, Takehiko Matsushita, Yuk Yu Chan

We generated Prx1CreER-GFP transgenic mice that express tamoxifen-inducible Cre recombinase and GFP under the control of a 2.4 kb Prx1 promoter. The transgene is expressed in osteochondro progenitor cells in the developing limb buds and in a subpopul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afb5b7aa67ee173c7898cc624b63e43
https://europepmc.org/articles/PMC2742350/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání