Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Aya HORIGUCHI"'
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Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes
Autor: Aya Horiguchi, Yaichiro Kotake, Chise Tateno, Hiroki Ohshita, Kazumi Sugihara, Naoto Uramaru, Shigeru Ohta, Seigo Sanoh, Shigeyuki Kitamura, Toru Horie, Yoshitaka Tayama
Publikováno v: Drug Metabolism and Disposition. 40:2267-2272
Prediction of human drug metabolism is important for drug development. Recently, the number of new drug candidates metabolized by not only cytochrome P450 (P450) but also non-P450 has been increasing. It is necessary to consider species differences i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480abf4bc81fe97a33d03ebe0bc86d81
https://doi.org/10.1124/dmd.112.047555
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5
Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver
Autor: Shigeru Ohta, Aya Horiguchi, Hiroki Ohshita, Toru Horie, Kazumi Sugihara, Shigeyuki Kitamura, Yaichiro Kotake, Seigo Sanoh, Chise Tateno, Yoshitaka Tayama
Publikováno v: Drug Metabolism and Disposition. 40:322-328
Accurate prediction of pharmacokinetics (PK) parameters in humans from animal data is difficult for various reasons, including species differences. However, chimeric mice with humanized liver (PXB mice; urokinase-type plasminogen activator/severe com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262b123ca7cf5bb32a8dd97ec2569718
https://doi.org/10.1124/dmd.111.040923
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6
Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver
Autor: Yoichi Naritomi, Aya Horiguchi, Koya Sato, Shigeru Ohta, Toru Horie, Hiroki Ohshita, Shigeyuki Kitamura, Mami Fujimoto, Akio Kawamura, Seigo Sanoh, Kazumi Sugihara, Yaichiro Kotake, Chise Tateno
Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 45(7)
1. We used chimeric mice (PXB mice®), which were repopulated with human hepatocytes, to evaluate their predictabilities of human pharmacokinetics. 2. The relationships of total clearance (CLt) and the volume of distribution at steady state (Vdss) be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac6c8689c0c3a836c729e6777a6b9c9
https://pubmed.ncbi.nlm.nih.gov/25733030
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