Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Aya D. Pusic"'
IFNγ-Stimulated Dendritic Cell Exosomes for Treatment of Migraine Modeled Using Spreading Depression
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Migraine is a common headache disorder characterized by unilateral, intense headaches. In migraine with aura, the painful headache is preceded by focal neurological symptoms that can be visual, sensory, or motor in nature. Spreading depression (the m
Externí odkaz:
https://doaj.org/article/f7437040a88c4222bca1055a5a95c1c8
Autor:
Peter J. Quesenberry, Jason Aliotta, Giovanni Camussi, Asim B. Abdel-Mageed, Sicheng Wen, Laura Goldberg, Huang-Ge Zhang, Ciro Tetta, Jeffrey Franklin, Robert J. Coffey, Kirsty Danielson, Vinita Subramanya, Ionita Ghiran, Saumya Das, Clark C. Chen, Kae M. Pusic, Aya D. Pusic, Devasis Chatterjee, Richard P. Kraig, Leonora Balaj, Mark Dooner
Publikováno v:
Journal of Extracellular Vesicles, Vol 4, Iss 0, Pp 1-11 (2015)
The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The
Externí odkaz:
https://doaj.org/article/e56fbab25197441eb1a243c1438a3ca6
Publikováno v:
Journal of Cellular Immunology. 3
Environmental enrichment produces beneficial effects in the brain at genetic, molecular, cellular and behavior levels, and has long been studied as a therapeutic intervention for a wide variety of neurological disorders. However, the complexity of ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7defd7b774534bb67d74231d69e3ba8
https://doi.org/10.33696/immunology.3.102
https://doi.org/10.33696/immunology.3.102
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255778 (2021)
PLoS ONE
PLoS ONE
Extracellular vesicles secreted from IFNγ-stimulated rat dendritic cells (referred to here as IFNγ-DC-EVs) contain miRNAs which promote myelination (including but not limited to miR-219), and preferentially enter oligodendrocytes in brain slice cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5eb793650a0b53d2c8064fab61246e
https://doaj.org/article/67b0f39d365e4ce49f3ef10ce6d64d1f
https://doaj.org/article/67b0f39d365e4ce49f3ef10ce6d64d1f
IFNγ-Stimulated Dendritic Cell Exosomes for Treatment of Migraine Modeled Using Spreading Depression
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Frontiers in Neuroscience
Frontiers in Neuroscience
Migraine is a common headache disorder characterized by unilateral, intense headaches. In migraine with aura, the painful headache is preceded by focal neurological symptoms that can be visual, sensory, or motor in nature. Spreading depression (the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c82422ac7b76e3d327d2d2ab5f5e36
https://doi.org/10.3389/fnins.2019.00942
https://doi.org/10.3389/fnins.2019.00942
Publikováno v:
Experimental Neurology. 264:43-54
Multiple sclerosis and migraine with aura are clinically correlated and both show imaging changes suggestive of myelin disruption. Furthermore, cortical myelin loss in the cuprizone animal model of multiple sclerosis enhances susceptibility to spread
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbd86af7dada472ee3588b7fe7552d3
https://doi.org/10.1016/j.expneurol.2014.12.001
https://doi.org/10.1016/j.expneurol.2014.12.001
Publikováno v:
Journal of Neuroimmunology. 266:12-23
Dendritic cells (DCs) release exosomes with different characteristics based on stimulus. Here, we showed that DC cultures stimulated with low-level IFNγ released exosomes (IFNγ-DC-Exos) that contained microRNA species that can increase baseline mye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a43bd398ff4255b46f91a1dd73d1e4
https://doi.org/10.1016/j.jneuroim.2013.10.014
https://doi.org/10.1016/j.jneuroim.2013.10.014
Autor:
Aya D. Pusic, Richard P. Kraig
Publikováno v:
Glia. 62:284-299
Although commonly considered a disease of white matter, gray matter demyelination is increasingly recognized as an important component of multiple sclerosis (MS) pathogenesis, particularly in the secondary progressive disease phase. Extent of damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86cb921a2e87e2fe44d9ea48ebfc6f7c
https://doi.org/10.1002/glia.22606
https://doi.org/10.1002/glia.22606
Environmental enrichment (EE) consists of increased physical, intellectual and social activity, and has wide-ranging effects, including enhancing cognition, learning and memory, and motor coordination. Animal studies have demonstrated that EE improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d534e35ef718d66b8f71c5d908627b69
https://europepmc.org/articles/PMC4860060/
https://europepmc.org/articles/PMC4860060/
Publikováno v:
Expert Review of Neurotherapeutics. 14:353-355
Current treatment options for multiple sclerosis are limited and consist of immunosuppressors or agents to prevent immune infiltration of the brain. These therapies have potentially harmful side effects and do little to promote myelin repair. Instead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd89c0681d512e1fd28f7d14a41134d6
https://doi.org/10.1586/14737175.2014.890893
https://doi.org/10.1586/14737175.2014.890893