Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Aya C Taki"'
Autor:
Harrison T. Shanley, Aya C. Taki, Joseph J. Byrne, Nghi Nguyen, Tim N. C. Wells, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-12 (2024)
Abstract Background Infection with parasitic nematodes (helminths), particularly those of the order Strongylida (such as Haemonchus contortus), can cause significant and burdensome diseases in humans and animals. Widespread drug (anthelmintic) resist
Externí odkaz:
https://doaj.org/article/c4b3a1f5948547319889689e50b53154
Autor:
Harrison T. Shanley, Aya C. Taki, Nghi Nguyen, Tao Wang, Joseph J. Byrne, Ching-Seng Ang, Michael G. Leeming, Nicholas Williamson, Bill C.H. Chang, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 25, Iss , Pp 100534- (2024)
Infections and diseases caused by parasitic nematodes have a major adverse impact on the health and productivity of animals and humans worldwide. The control of these parasites often relies heavily on the treatment with commercially available chemica
Externí odkaz:
https://doaj.org/article/e3738831bebf4b19be4951ffbbc3215f
Autor:
Harrison T. Shanley, Aya C. Taki, Nghi Nguyen, Tao Wang, Joseph J. Byrne, Ching-Seng Ang, Michael G. Leeming, Shuai Nie, Nicholas Williamson, Yuanting Zheng, Neil D. Young, Pasi K. Korhonen, Andreas Hofmann, Bill C.H. Chang, Tim N.C. Wells, Cécile Häberli, Jennifer Keiser, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 24, Iss , Pp 100522- (2024)
Within the context of our anthelmintic discovery program, we recently identified and evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal candidate; synthesised a series of analogues which were assessed for activity against
Externí odkaz:
https://doaj.org/article/bd1202bcf63a4ff0ade2f378a914072b
Autor:
Pasi K. Korhonen, Tao Wang, Neil D. Young, Joseph J. Byrne, Tulio L. Campos, Bill C.H. Chang, Aya C. Taki, Robin B. Gasser
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1026-1035 (2024)
Advances in single cell technologies are allowing investigations of a wide range of biological processes and pathways in animals, such as the multicellular model organism Caenorhabditis elegans – a free-living nematode. However, there has been limi
Externí odkaz:
https://doaj.org/article/7ab010327aba4ea691e436fd01e2f0e5
Autor:
Deepika Dugan, Rachael J. Bell, Robert Brkljača, Colin Rix, Aya C. Taki, Robin B. Gasser, Sylvia Urban
Publikováno v:
Metabolites, Vol 14, Iss 5, p 259 (2024)
Phytochemical profiling followed by antimicrobial and anthelmintic activity evaluation of the Australian plant Geijera parviflora, known for its customary use in Indigenous Australian ceremonies and bush medicine, was performed. In the present study,
Externí odkaz:
https://doaj.org/article/bb39311c8a654bc1811d510ca44f2446
Autor:
Ivana Skakic, Aya C. Taki, Jasmine E. Francis, Chaitali Dekiwadia, Thi Thu Hao Van, Carina C. D. Joe, Tram Phan, George Lovrecz, Paul R. Gorry, Paul A. Ramsland, Anna K. Walduck, Peter M. Smooker
Publikováno v:
Vaccines, Vol 12, Iss 4, p 410 (2024)
Nanoparticles show great promise as a platform for developing vaccines for the prevention of infectious disease. We have been investigating a method whereby nanocapsules can be formulated from protein, such that the final capsules contain only the cr
Externí odkaz:
https://doaj.org/article/98da660166304ea9894cf478fc094f25
Autor:
Jasmine E. Francis, Ivana Skakic, Debolina Majumdar, Aya C. Taki, Ravi Shukla, Anna Walduck, Peter M. Smooker
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1076 (2024)
In this study, novel solid lipid particles containing the adjuvant lipid monophosphoryl lipid A (termed ‘SLN-A’) were synthesised. The SLN-A particles were able to efficiently bind and form complexes with a DNA vaccine encoding the urease alpha s
Externí odkaz:
https://doaj.org/article/9130ca5d8b50492e991d0df9651904ba
Autor:
Ivana Skakic, Jasmine E. Francis, Chaitali Dekiwadia, Ibukun Aibinu, Mohsina Huq, Aya C. Taki, Anna Walduck, Peter M. Smooker
Publikováno v:
Vaccines, Vol 11, Iss 11, p 1652 (2023)
Using removable silica templates, protein nanocapsules comprising the A subunit of Helicobacter pylori urease (UreA) were synthesised. The templates were of two sizes, with solid core mesoporous shell (SC/MS) silica templates giving rise to nanocapsu
Externí odkaz:
https://doaj.org/article/8a8293f534c746a1a7c7ef3b46d113e0
Autor:
Tao Wang, Tiana F. Koukoulis, Laura J. Vella, Huaqi Su, Adityas Purnianto, Shuai Nie, Ching-Seng Ang, Guangxu Ma, Pasi K. Korhonen, Aya C. Taki, Nicholas A. Williamson, Gavin E. Reid, Robin B. Gasser
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10955 (2023)
Many parasitic worms have a major adverse impact on human and animal populations worldwide due to the chronicity of their infections. There is a growing body of evidence indicating that extracellular vesicles (EVs) are intimately involved in modulati
Externí odkaz:
https://doaj.org/article/adfb533c4ad5440080845c416c1e854a
Autor:
Aya C. Taki, Tao Wang, Nghi N. Nguyen, Ching-Seng Ang, Michael G. Leeming, Shuai Nie, Joseph J. Byrne, Neil D. Young, Yuanting Zheng, Guangxu Ma, Pasi K. Korhonen, Anson V. Koehler, Nicholas A. Williamson, Andreas Hofmann, Bill C. H. Chang, Cécile Häberli, Jennifer Keiser, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. The control of these parasites relies heavily on anthelmintic therapy, but treatment failures and resistance to these dru
Externí odkaz:
https://doaj.org/article/9c2e2b7509564909be768e1c02e98074