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Monocarboxylate Transporters Are Involved in Extracellular Matrix Remodelling in Pancreatic Ductal Adenocarcinoma

Autor: Ayşe Ufuk, Terence Garner, Adam Stevens, Ayşe Latif

Publikováno v: Cancers; Volume 14; Issue 5; Pages: 1298
Ufuk, A, Garner, T, Stevens, A & Latif, A 2022, ' Monocarboxylate Transporters Are Involved in Extracellular Matrix Remodelling in Pancreatic Ductal Adenocarcinoma ', Cancers, vol. 14, no. 5, 1298 . https://doi.org/10.3390/cancers14051298

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a five-year survival rate of Simple SummaryMonocarboxylate transporters (MCTs) carry a variety of substrates with MCT1-4 being well characterised and involved in proton-coupled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083d6542918c66261aa1440a4afbf199

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Müzede yaratıcı drama etkinlikleri ile sosyal bilgiler dersi kazanımlarına ilişkin öğrenci görüşlerinin değerlendirilmesi

Autor: Boyaci, Ayşe Ufuk

Günümüzde müze eğitimi, önemi gittikçe daha çok anlaşılan bir kavram olarak karşımıza çıkmaktadır. Müze eğitimi uygulamaları ile müze ziyaretçileri sergilenmekte olan materyallerle etkileşimde bulunma olanağına kavuşmaktadır

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10208::48089b40fae724b0eafe8bf124d895e8
https://acikbilim.yok.gov.tr/handle/20.500.12812/83637

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Hepatic Organic Anion Transporting Polypeptide-Mediated Clearance in the Beagle Dog: Assessing In Vitro-In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance

Autor: Kathleen M. Hillgren, David W. Bedwell, Bridget L. Morse, Norikazu Matsunaga, Aleksandra Galetin, Michael A. Mohutsky, J. Brian Houston, Stephen D. Hall, Jingqi Bao, Ayşe Ufuk

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 47(3)

In the present study, the beagle dog was evaluated as a preclinical model to investigate organic anion transporting polypeptide (OATP)-mediated hepatic clearance. In vitro studies were performed with nine OATP substrates in three lots of plated male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb817a0a084336e51ee431628a28b214
https://pubmed.ncbi.nlm.nih.gov/30593544

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Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance

Autor: A. David Rodrigues, Manthena V.S. Varma, Sweta Modi, Carina Cantrill, Ayşe Ufuk, Mark Niosi, Tom De Bruyn, Yi An Bi, Rachel E. Kosa, J. Brian Houston, Aleksandra Galetin, Larry M. Tremaine

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 46(7)

This work explores the utility of the cynomolgus monkey as a preclinical model to predict hepatic uptake clearance mediated by organic anion transporting polypeptide (OATP) transporters. Nine OATP substrates (rosuvastatin, pravastatin, repaglinide, f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e815acb044ed7774f8725c3f309670
https://pubmed.ncbi.nlm.nih.gov/29720472

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In Vitro-In Vivo Extrapolation of OATP1B-Mediated Drug-Drug Interactions in Cynomolgus Monkey

Autor: Dana Gates, A. David Rodrigues, Hongying Gao, J. Brian Houston, Manthena V.S. Varma, Rachel E. Kosa, Yi An Bi, Ayşe Ufuk, Aleksandra Galetin, Larry M. Tremaine, Sweta Modi

Publikováno v: The Journal of pharmacology and experimental therapeutics. 365(3)

Hepatic organic anion-transporting polypeptides (OATP) 1B1 and 1B3 are clinically relevant transporters associated with significant drug-drug interactions (DDIs) and safety concerns. Given that OATP1Bs in cynomolgus monkey share >90% degree of gene a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac2f8569348c099f8fe868fcd381679
https://pubmed.ncbi.nlm.nih.gov/29643253

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In Vitro and in Silico Tools To Assess Extent of Cellular Uptake and Lysosomal Sequestration of Respiratory Drugs in Human Alveolar Macrophages

Autor: Ayşe, Ufuk, Frauke, Assmus, Laura, Francis, Jonathan, Plumb, Valeriu, Damian, Michael, Gertz, J Brian, Houston, Aleksandra, Galetin

Publikováno v: Molecular pharmaceutics. 14(4)

Accumulation of respiratory drugs in human alveolar macrophages (AMs) has not been extensively studied in vitro and in silico despite its potential impact on therapeutic efficacy and/or occurrence of phospholipidosis. The current study aims to charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2e885c35cf62f600441d2c1caa64c97
https://pubmed.ncbi.nlm.nih.gov/28252969

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The contribution of lysosomal sequestration to intracellular drug accumulation and its assessment by in vitro and in silico methods

Autor: Ayşe Ufuk

Publikováno v: Drug Metabolism and Pharmacokinetics. 33:S11-S12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4580e8ac03167fce7f5b28de00642611
https://doi.org/10.1016/j.dmpk.2017.11.056

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In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383

Autor: Ayşe, Ufuk, Graham, Somers, J Brian, Houston, Aleksandra, Galetin

Publikováno v: Pharmaceutical Research

Purpose To assess accumulation and lysosomal sequestration of 9 drugs used in respiratory indications (plus imipramine as positive control) in the alveolar macrophage (AM) cell line NR8383. Methods For all drugs, uptake at 5 μM was investigated at 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f4fb716029a433571adddd52cc29d4c
https://pubmed.ncbi.nlm.nih.gov/26224396

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