Zobrazeno 1 - 10
of 3 185
pro vyhledávání: '"Axonal degeneration"'
Autor:
Panpan Wang, Yaping Shao, Murad Al-Nusaif, Jun Zhang, Huijia Yang, Yuting Yang, Kunhyok Kim, Song Li, Cong Liu, Huaibin Cai, Weidong Le
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-28 (2024)
Abstract Background Although WD repeat domain 45 (WDR45) mutations have been linked to $$\upbeta$$ β -propeller protein-associated neurodegeneration (BPAN), the precise molecular and cellular mechanisms behind this disease remain elusive. This study
Externí odkaz:
https://doaj.org/article/024e6a2fdb0f485cae89eca726a3613e
Autor:
Shuo Yang, Na Chen, Lei Zhang, Ying Wang, Lin Chen, Fan Jian, Zaiqiang Zhang, Yilong Wang, Hua Pan
Publikováno v:
Brain and Behavior, Vol 14, Iss 10, Pp n/a-n/a (2024)
Abstract Background We aimed to identify different Guillain–Barré syndrome (GBS) subtypes, demyelination, axonal degeneration, and reversible conduction failure (RCF) as early as possible by analyzing the initial clinical and electrophysiological
Externí odkaz:
https://doaj.org/article/01175cfa39cc4270b16c50a21169d5d5
Autor:
Spencer Ames, Jesse Brooks, Emma Jones, Johnny Morehouse, Francisco Cortez-Thomas, Dereje Desta, David P. Stirling
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106611- (2024)
Ultrastructural studies of contusive spinal cord injury (SCI) in mammals have shown that the most prominent acute changes in white matter are periaxonal swelling and separation of myelin away from their axon, axonal swelling, and axonal spheroid form
Externí odkaz:
https://doaj.org/article/0c392e39a26b4290b6f49a78aca9428f
Autor:
Yohei Nitta, Jiro Osaka, Ryuto Maki, Satoko Hakeda-Suzuki, Emiko Suzuki, Satoshi Ueki, Takashi Suzuki, Atsushi Sugie
Publikováno v:
eLife, Vol 12 (2024)
Autosomal dominant optic atrophy (DOA) is a progressive form of blindness caused by degeneration of retinal ganglion cells and their axons, mainly caused by mutations in the OPA1 mitochondrial dynamin like GTPase (OPA1) gene. OPA1 encodes a dynamin-l
Externí odkaz:
https://doaj.org/article/317f38a29ccb41449afbb6ff8364ca5e
Autor:
Huilan Zeng, Jordan E. Mayberry, David Wadkins, Nathan Chen, Daniel W. Summers, Markus H. Kuehn
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Glaucoma is one of the leading causes of irreversible blindness worldwide and vision loss in the disease results from the deterioration of retinal ganglion cells (RGC) and their axons. Metabolic dysfunction of RGC plays a significant role in
Externí odkaz:
https://doaj.org/article/0248a49f57ee472abd79202151455b34
Autor:
Yongchao Mou, Ghata Nandi, Sukhada Mukte, Eric Chai, Zhenyu Chen, Jorgen E. Nielsen, Troels T. Nielsen, Chiara Criscuolo, Craig Blackstone, Matthew J. Fraidakis, Xue-Jun Li
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-16 (2023)
Abstract Background Biallelic mutations in CYP27A1 and CYP7B1, two critical genes regulating cholesterol and bile acid metabolism, cause cerebrotendinous xanthomatosis (CTX) and hereditary spastic paraplegia type 5 (SPG5), respectively. These rare di
Externí odkaz:
https://doaj.org/article/da1bf0a071b64f849bc224f6de04b0b9
Publikováno v:
BMC Neurology, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Background Elevated serum creatine kinase (CK) levels have been reported in patients with Guillain–Barré syndrome (GBS), more frequently in patients with acute motor axonal neuropathy (AMAN) than in those with acute inflammatory demyelina
Externí odkaz:
https://doaj.org/article/9cf6ed5994cf406792cc0e1bec89f725
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106293- (2023)
Spastic paraplegia type 11 (SPG11) is a common autosomal recessive form of hereditary spastic paraplegia (HSP) characterized by the degeneration of cortical motor neuron axons, leading to muscle spasticity and weakness. Impaired lipid trafficking is
Externí odkaz:
https://doaj.org/article/5920107ee5f14e7f82e27187ba3e1e37
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 12, Pp 2720-2726 (2023)
[INLINE:1] The formation of axonal spheroid is a common feature following spinal cord injury. To further understand the source of Ca2+ that mediates axonal spheroid formation, we used our previously characterized ex vivo mouse spinal cord model that
Externí odkaz:
https://doaj.org/article/6a901a257627426db104d581c6c6cb9d
Autor:
Irene Frigerio, Max A. Laansma, Chen-Pei Lin, Emma J. M. Hermans, Maud M. A. Bouwman, John G. J. M. Bol, Yvon Galis-de Graaf, Dagmar H. Hepp, Annemieke J. M. Rozemuller, Frederik Barkhof, Wilma D. J. van de Berg, Laura E. Jonkman
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-17 (2023)
Abstract Background Increased neurofilament levels in biofluids are commonly used as a proxy for neurodegeneration in several neurodegenerative disorders. In this study, we aimed to investigate the distribution of neurofilaments in the cerebral corte
Externí odkaz:
https://doaj.org/article/a960a86f115f4169871e57f28d3671a5