Výsledky vyhledávání - "Axinellamine"

Akademický článek

Identification of Axinellamines A and B as Anti-Tubercular Agents

Autor: Emily J. Strong, Lendl Tan, Sasha Hayes, Hayden Whyte, Rohan A. Davis, Nicholas P. West

Publikováno v: Marine Drugs, Vol 22, Iss 7, p 298 (2024)

Tuberculosis remains a significant global health pandemic. There is an urgent need for new anti-tubercular agents to combat the rising incidence of drug resistance and to offer effective and additive therapeutic options. High-throughput screening of

Externí odkaz: https://doaj.org/article/90debecfbc8e405cb567616a62ee7621

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Akademický článek

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Asymmetric Synthesis of Axinellamines A and B

Autor: Yuyong Ma, Xiao Wang, Zhiqiang Ma, Chuo Chen

Publikováno v: Angewandte Chemie. 128:4841-4844

Axinellamines A and B are broad-spectrum anti-bacterial pyrrole–imidazole alkaloids that have a complex polycyclic skeleton. A new asymmetric synthesis of these marine sponge metabolites is described herein, featuring an oxidative rearrangement and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bcf04901367de65b92efdc241721832
https://doi.org/10.1002/ange.201600007

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Intramolecular Diels-Alder Reaction of a Silyl-Substituted Vinylimidazole en Route to the Fully Substituted Cyclopentane Core of Oroidin Dimers

Autor: Carl J. Lovely, Delphine Gout, Muhammed Yousufuddin, Abhisek Ray

Publikováno v: Organic letters. 20(18)

An intramolecular Diels–Alder reaction of a silyl-substituted vinylimidazole delivers a diastereomeric mixture of C4-silyl functionalized dihydrobenzimidazoles. Subsequent diastereoselective reduction and elaboration of the lactone gives rise to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb442ff29e561b4f5731c457c1286e1
https://pubmed.ncbi.nlm.nih.gov/30192150

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Total synthesis of ageliferin via acyl N-amidinyliminium ion rearrangement

Autor: Patrick G. Harran, Hui Ding, Andrew G. Roberts

Publikováno v: Chem. Sci.. 4:303-306

Ageliferin is a marine natural product having antiviral and antimicrobial activities. These functions remain to be characterized at a molecular level. Ageliferin is also thought a biosynthetic intermediary linking oroidin type alkaloids to more compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2ab7a8f8eab44082fb2bc5b7b6009c
https://doi.org/10.1039/c2sc21651e

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Studies toward the Total Synthesis of Axinellamine and Massadine

Autor: Rasapalli Sivappa, Carl J. Lovely, Nora M. Hernandez, Yong He

Publikováno v: Organic Letters. 9:3861-3864

Intramolecular Diels-Alder reactions of several N-O linked 4-vinylimidazole dimers provide the expected adduct in moderate to good yield as a single, all trans stereoisomer, along with smaller amounts of the inverse electron demand adduct. Oxidative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4048b145d45bb2240ccb3111531224d
https://doi.org/10.1021/ol0711568

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The Absolute Configuration of Axinellamine A, a Pyrrole Alkaloid of the Marine SpongeAxinella sp., was Determined asR by Synthesizing Its (S)-Isomer

Autor: Kenji Mori, Masanori Seki

Publikováno v: European Journal of Organic Chemistry. 2001:503-506

(S)-(+)-Axinellamine A [(2E,4E,6S)-2-(6-methyl-2,4-octadienyl)pyrrole, 1] was synthesized by starting from (S)-(−)-2-methylbutan-1-ol and pyrrole. The absolute configuration of the naturally occurring (−)-axinellamine A, a metabolite of the marin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b4c2a46090b605c0471862dbf752a5c
https://doi.org/10.1002/1099-0690(200102)2001:3<503::aid-ejoc503>3.0.co

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Symmetry-Based Access to Polycyclic Bis-guanidines: Total Synthesis of (±)-Ageliferin and the Complete Axinellamine Ring System

Autor: Roberts, Andrew George

Publikováno v: Roberts, Andrew George. (2013). Symmetry-Based Access to Polycyclic Bis-guanidines: Total Synthesis of (±)-Ageliferin and the Complete Axinellamine Ring System. UCLA: Chemistry 0153. Retrieved from: http://www.escholarship.org/uc/item/7d94j8wz

We have charted a symmetry-based approach to complex, dimeric members of the pyrrole–imidazole family of alkaloids; palau'amine, axinellamines, massadines and ageliferin. New methods to prepare and manipulate bis-guanidine containing intermediates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::8a364ad5b981ab6d59c0db65386cfbb9
http://www.escholarship.org/uc/item/7d94j8wz

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Dissertation/ Thesis

Synthetic Studies Toward Selected Members of the Pyrrole-imidazole Alkaloids: Axinellamine, Konbu'acidin and Palau' amine

Autor: Zancanella, Manuel

The pyrrole imidazole alkaloids (PIA) is an ever-growing family of structurally related natural products isolated from several species of sponges which now features more than one hundred memebrs. Their complex molecular architectures, and in some cas

Externí odkaz: http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8217

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