Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Axia Song"'
Autor:
Rebecca J. Austin, Jasmin Straube, Rohit Halder, Yashaswini Janardhanan, Claudia Bruedigam, Matthew Witkowski, Leanne Cooper, Amy Porter, Matthias Braun, Fernando Souza-Fonseca-Guimaraes, Simone A. Minnie, Emily Cooper, Sebastien Jacquelin, Axia Song, Tobias Bald, Kyohei Nakamura, Geoffrey R. Hill, Iannis Aifantis, Steven W. Lane, Megan J. Bywater
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Acute myeloid leukemia (AML) is a genetically heterogeneous, aggressive hematological malignancy induced by distinct oncogenic driver mutations. The effect of specific AML oncogenes on immune activation or suppression is unclear. Here, we ex
Externí odkaz:
https://doaj.org/article/1fe1b18939ee4e878a49fa928f9e503d
Autor:
Therese Vu, Jasmin Straube, Amy H. Porter, Megan Bywater, Axia Song, Victoria Ling, Leanne Cooper, Gabor Pali, Claudia Bruedigam, Sebastien Jacquelin, Joanne Green, Graham Magor, Andrew Perkins, Alistair M. Chalk, Carl R. Walkley, Florian H. Heidel, Pamela Mukhopadhyay, Nicole Cloonan, Stefan Gröschel, Jan-Philipp Mallm, Stefan Fröhling, Claudia Scholl, Steven W. Lane
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells in the majority of patients with leukemia but not during normal blood formation. Here, the authors report a mouse model with conditional Cdx2 expression showing de n
Externí odkaz:
https://doaj.org/article/bceafc18d13641ee9c5212ab1db8af73
Autor:
Therese Vu, Rebecca Austin, Catherine Paine Kuhn, Claudia Bruedigam, Axia Song, Solene Guignes, Sebastien Jacquelin, Hayley S. Ramshaw, Geoffrey R. Hill, Angel F. Lopez, Steven W. Lane
Publikováno v:
Haematologica, Vol 101, Iss 3 (2016)
Externí odkaz:
https://doaj.org/article/54f9ec013fe54efcaf567ddfb3805757
Autor:
Claudia Bruedigam, Amy H. Porter, Axia Song, Gerjanne Vroeg in de Wei, Thomas Stoll, Jasmin Straube, Leanne Cooper, Guidan Cheng, Vivian F. S. Kahl, Alexander P. Sobinoff, Victoria Y. Ling, Billy Michael Chelliah Jebaraj, Yashaswini Janardhanan, Rohit Haldar, Laura J. Bray, Lars Bullinger, Florian H. Heidel, Glen A. Kennedy, Michelle M. Hill, Hilda A. Pickett, Omar Abdel-Wahab, Gunter Hartel, Steven W. Lane
Telomerase enables replicative immortality in most cancers including acute myeloid leukemia (AML). Imetelstat is a first-in-class telomerase inhibitor with clinical efficacy in myelofibrosis and myelodysplastic syndromes. Here, we develop an AML pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7688131f3802bfcdf7c6a73829158521
https://doi.org/10.1101/2023.04.25.538357
https://doi.org/10.1101/2023.04.25.538357
Autor:
Dang Hai Nguyen, Sayantani Sinha, Zhiyan Silvia Liu, Maxwell Henry Bannister, Erica Arriaga-Gomez, Axia Song, Dawei Zong, Martina Sarchi, Victor Corral, Wannasiri Chiraphapphaiboon, Jennifer Yoo, Matthew McMahon, Cassandra Leibson, Derek L. Stirewalt, H Joachim Deeg, Sumit Rai, Matthew Walter, Timothy A. Graubert, Sergei Doulatov, Stanley C. Lee
Publikováno v:
Cancer Research. 83:6183-6183
Somatic heterozygous mutations in genes encoding for RNA splicing factors (SF) SRSF2, U2AF1, and SF3B1 are frequently mutated in patients with hematologic malignancies, representing a unique genetic vulnerability for targeted therapy. In the current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::230c8b2a41206cb7c257a9f9ea3be723
https://doi.org/10.1158/1538-7445.am2023-6183
https://doi.org/10.1158/1538-7445.am2023-6183
Autor:
Claudia Bruedigam, Amy H Porter, Axia Song, Gerjanne Vroeg in de Wei, Thomas Stoll, Jasmin Straube, Leanne T Cooper, Guidan Cheng, Vivian FS Kahl, Alexander Sobinoff, Victoria Y Ling, Billy Michael Chelliah Jebaraj, Laura J Bray, Lars Bullinger, Florian H Heidel, Glen A Kennedy, Michelle M Hill, Hilda Pickett, Omar Abdel-Wahab, Gunter Hartel, Steven W Lane
Publikováno v:
Blood. 140:487-488
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947d3383363c827008a4a8206bf1d5b1
https://doi.org/10.1182/blood-2022-168166
https://doi.org/10.1182/blood-2022-168166
Autor:
Nicole Cloonan, Leanne Cooper, Gabor Pali, Alistair M. Chalk, Stefan Gröschel, Jasmin Straube, Therese Vu, Joanne Green, Jan-Philipp Mallm, Stefan Fröhling, Steven W. Lane, Florian H. Heidel, Andrew C. Perkins, Claudia Bruedigam, Megan Bywater, Sebastien Jacquelin, Graham Magor, Carl R. Walkley, Claudia Scholl, Pamela Mukhopadhyay, Amy H. Porter, Axia Song, Victoria Ling
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells but not during normal blood formation. Retroviral overexpression of Cdx2 induces AML in mice, however the developmental stage at which CDX2 exerts its effect is unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbe877fde588889a7954b2e6dadf7b7
https://acuresearchbank.acu.edu.au/item/8vy47/hematopoietic-stem-and-progenitor-cell-restricted-cdx2-expression-induces-transformation-to-myelodysplasia-and-acute-leukemia
https://acuresearchbank.acu.edu.au/item/8vy47/hematopoietic-stem-and-progenitor-cell-restricted-cdx2-expression-induces-transformation-to-myelodysplasia-and-acute-leukemia
Autor:
Rebecca Austin, Brad Wackrow, Joanne Green, Victoria Ling, Jasmin Straube, Leanne Cooper, Therese Vu, Axia Song, Konstanze Döhner, Luke B. Hesson, Matthew Heidecker, Eva Baxter, John E. Pimanda, Dirk Heckl, Megan Bywater, Stephen H. Kazakoff, Nicola Waddell, Sebastien Jacquelin, Raajit K. Rampal, Geoffrey R. Hill, Steven W. Lane, Frank Stegelmann, Amy H. Porter, Lars Bullinger
Publikováno v:
Blood. 132(26)
Myeloproliferative neoplasms (MPNs) are a group of blood cancers that arise following the sequential acquisition of genetic lesions in hematopoietic stem and progenitor cells (HSPCs). We identify mutational cooperation between Jak2V617F expression an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbf2ddd0c4f2413eed4813df1f33f1f
https://pubmed.ncbi.nlm.nih.gov/30591541
https://pubmed.ncbi.nlm.nih.gov/30591541
Autor:
Axia Song, Geoffrey R. Hill, Steven W. Lane, Claudia Bruedigam, Angel F. Lopez, Hayley S. Ramshaw, Therese Vu, Sebastien Jacquelin, Catherine Paine Kuhn, Solene Guignes, Rebecca Austin
Publikováno v:
Haematologica. 101:e77-e80
Myeloproliferative neoplasms (MPN) are a phenotypically defined, heterogeneous group of blood cancers characterised by the proliferation of progenitor cells and the accumulation of mature myeloid cells, linked by a propensity to transform into myelof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523fd48c5b4b46af9f29bb60744c771a
https://doi.org/10.3324/haematol.2015.136705
https://doi.org/10.3324/haematol.2015.136705
Autor:
Geoffrey R. Hill, Steven W. Lane, Richard B. Lock, Catherine Paine Kuhn, David A. Williams, Therese Vu, Erwin M. Lee, Frederik Otzen Bagger, Andrew S. Moore, Lars Bullinger, Scott A. Armstrong, Florian H. Heidel, Solene Guignes, Axia Song, Sarbjit Riyat, Claudia Bruedigam, Rebecca Austin
Publikováno v:
Cell Stem Cell. 15(6):775-790
SummaryAcute myeloid leukemia (AML) is an aggressive and lethal blood cancer maintained by rare populations of leukemia stem cells (LSCs). Selective targeting of LSCs is a promising approach for treating AML and preventing relapse following chemother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fcef1c6d9627a8ee6ab75656f95a60