Antibodies toward Na⁺,HCO3^–-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer.

Autor: Axelsen, Trine V., Olesen, Claus, Khan, Danish, Mohammadi, Ali, Bouzinova, Elena V., Nielsen, Christine J. F., Mele, Marco, Hauerslev, Katrine R., Pedersen, Helene L., Balling, Eva, Vahl, Pernille, Tramm, Trine, Christiansen, Peer M., Boedtkjer, Ebbe

Publikováno v: British Journal of Cancer; Apr2024, Vol. 130 Issue 7, p1206-1220, 15p

Additional file 1 of Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

Autor: Lee, Soojung, Toft, Nicolai J., Axelsen, Trine V., Espejo, Maria Sofia, Pedersen, Tina M., Mele, Marco, Pedersen, Helene L., Balling, Eva, Johansen, Tonje, Burton, Mark, Thomassen, Mads, Vahl, Pernille, Christiansen, Peer, Boedtkjer, Ebbe

Additional file 1. Supplementary tables and figures. Table S1 summarizes the clinical and pathological patient characteristics. Table S2 and S3 provide sequence information for primers and probes used for quantitative RT-PCR analyses. Table S4 and S5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935d8aab7b9fc6f74ef12674bd4bf659

Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival.

Autor: Sloth, Rasmus A., Axelsen, Trine V., Espejo, Maria Sofia, Toft, Nicolai J., Voss, Ninna C. S., Burton, Mark, Thomassen, Mads, Vahl, Pernille, Boedtkjer, Ebbe

Publikováno v: British Journal of Cancer; Oct2022, Vol. 127 Issue 7, p1226-1238, 13p

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Antibodies toward Na ⁺ ,HCO 3 ^- -cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer.

Autor: Axelsen TV; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Olesen C; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Khan D; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Mohammadi A; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Bouzinova EV; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Nielsen CJF; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Mele M; Department of Surgery, Randers Regional Hospital, Randers, Denmark., Hauerslev KR; Department of Plastic and Breast Surgery, Aarhus University Hospital, Aarhus, Denmark., Pedersen HL; Department of Pathology, Randers Regional Hospital, Randers, Denmark., Balling E; Department of Surgery, Randers Regional Hospital, Randers, Denmark., Vahl P; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Tramm T; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Christiansen PM; Department of Surgery, Randers Regional Hospital, Randers, Denmark.; Department of Plastic and Breast Surgery, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Boedtkjer E; Department of Biomedicine, Aarhus University, Aarhus, Denmark. eb@biomed.au.dk.

Publikováno v: British journal of cancer [Br J Cancer] 2024 Apr; Vol. 130 (7), pp. 1206-1220. Date of Electronic Publication: 2024 Feb 03.