Výsledky vyhledávání - "Axelle Cadoret"

Endoplasmic reticulum stress induces inverse regulations of major functions in portal myofibroblasts during liver fibrosis progression

Autor: Lin Lei, Haquima El Mourabit, Emilien Loeuillard, Chantal Housset, Sara Lemoinne, Axelle Cadoret

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864:3688-3696

Portal myofibroblasts (PMF) form a sub-population of highly proliferative and proangiogenic liver myofibroblasts that derive from portal mesenchymal progenitors. Endoplasmic reticulum (ER) stress was previously shown to modulate fibrogenesis, notably

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07461265d3779e831c3755e3591001d
https://doi.org/10.1016/j.bbadis.2018.10.008

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Cholangiopathy aggravation is caused by VDR ablation and alleviated by VDR-independent vitamin D signaling in ABCB4 knockout mice

Autor: Marie Clavel, Haquima El Mourabit, Marion Jager, Sophie Moog, Ester Gonzalez-Sanchez, Jérémie Gautheron, Tatiana Ledent, Chantal Housset, Laura Fouassier, Dominique Wendum, Axelle Cadoret, Javier Vaquero, Nicolas Chignard

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease. 1867(4)

Background & aims Cholangiopathies are chronic liver diseases in which damaged cholangiocytes trigger a proinflammatory and profibrotic reaction. The nuclear vitamin D receptor (VDR) is highly expressed in cholangiocytes and exerts immune-regulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb695dccf53857579d6a2944a3d2e8f
https://pubmed.ncbi.nlm.nih.gov/33418034

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Role of Angiogenesis in the Pathogenesis of NAFLD

Autor: Chantal Housset, Sara Lemoinne, Axelle Cadoret, Haquima Ei Mourabit, Lin Lei

Publikováno v: Journal of Clinical Medicine
Journal of Clinical Medicine, MDPI, 2021, 10 (7), pp.1338. ⟨10.3390/jcm10071338⟩
Journal of Clinical Medicine, Vol 10, Iss 1338, p 1338 (2021)
Journal of Clinical Medicine, 2021, 10 (7), pp.1338. ⟨10.3390/jcm10071338⟩

International audience; Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease, exposing to the risk of liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Angio-genesis is a complex process leading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27b4c1f9e34965458e7756141830ee0
https://doi.org/10.3390/jcm10071338

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Portal myofibroblasts promote vascular remodeling underlying cirrhosis formation through the release of microparticles

Autor: Chantal M. Boulanger, Axelle Cadoret, Colette Rey, Christophe Corpechot, Chantal Housset, Véronique Barbu, Dominique Thabut, Pierre-Emmanuel Rautou, Nelly Bosselut, Sara Lemoinne, Haquima El Mourabit, Gérard Feldmann, Dominique Wendum, Vlad Ratziu, Corneliu Henegar

Publikováno v: Hepatology. 61:1041-1055

Liver fibrosis expanding from portal tracts and vascular remodeling are determinant factors in the progression of liver diseases to cirrhosis. In the present study, we examined the potential contribution of portal myofibroblasts (PMFs) to the vascula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87ce236c2b991d7fd07a56f794b7e35a
https://doi.org/10.1002/hep.27318

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Origins and functions of liver myofibroblasts

Autor: Haquima El Mourabit, Axelle Cadoret, Sara Lemoinne, Chantal Housset, Dominique Thabut

Publikováno v: Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease; Vol 1832

Myofibroblasts combine the matrix-producing functions of fibroblasts and the contractile properties of smooth muscle cells. They are the main effectors of fibrosis in all tissues and make a major contribution to other aspects of the wound healing res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf1bdf5945b79e92383cbad11d8ee31

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During the progression of liver fibrosis, myofibroblasts develop endoplasmic reticulum stress that both decreases their proliferation and increases their pro-angiogenic activity

Autor: E. Loeuillard, Haquima El Mourabit, Axelle Cadoret, Chantal Housset, L. Lei, Sara Lemoinne

Publikováno v: Journal of Hepatology. 68:S400

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d479eb244130e77cb3670f89a6ad8136
https://doi.org/10.1016/s0168-8278(18)31037-7

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Dysregulation of glycogen synthase kinase-3β signaling in hepatocellular carcinoma cells

Autor: R. Delelo, Jacqueline Capeau, Christèle Desbois-Mouthon, Axelle Cadoret, Marie-José Blivet-Van Eggelpoë, Eléonore Beurel, Mathieu Boissan

Publikováno v: Hepatology. 36:1528-1536

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28852bbc92922c6c1bf209fd73f9c7ae
https://doi.org/10.1002/hep.1840360630

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Dysregulation of glycogen synthase kinase-3β signaling in hepatocellular carcinoma cells

Autor: Marie José Blivet-Van Eggelpoël, Roland Delélo, Eléonore Beurel, Jacqueline Capeau, Mathieu Boissan, Christèle Desbois-Mouthon, Axelle Cadoret

Publikováno v: Hepatology. 36:1528-1536

It has been reported that upstream components of the insulin-like growth factor (IGF) signaling axis could be overexpressed during hepatocarcinogenesis in humans and rodents. However, the signal transduction pathways activated downstream have been po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5304e90f74d2709179868e171d9e0c61
https://doi.org/10.1053/jhep.2002.37192

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New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism

Autor: Wouter H. Lamers, Christine Perret, Jan Kitajewski, Axel Kahn, Benoit Terris, Laurence Lévy, Christine Ovejero, Evelyne Souil, Axelle Cadoret

Publikováno v: Oncogene, 21(54), 8293-8301. Nature Publishing Group
Oncogene, 21(54), 8293-82301. Nature Publishing Group

New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism.Cadoret A, Ovejero C, Terris B, Souil E, Levy L, Lamers WH, Kitajewski J, Kahn A, Perret C.Departement de Genetique, Developpement et Pathologie Moleculaire,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95b9c851c7d22f73e7ae207440353b6
https://doi.org/10.1038/sj.onc.1206118

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