Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Axel Unterbeck"'
Autor:
Steve Carney, Axel Unterbeck
Publikováno v:
Drug Discovery Today. 10:165-168
Publikováno v:
genesis. 32:102-104
Autor:
Donald L. Price, Shelia M. Violette, Stanley B. Prusiner, Paul J. Shlichta, Frank H. Ruddle, George A. Scangos, Blas Frangione, Dana O. Wirak, Karen K. Hsiao, Sangram S. Sisodia, Colin L. Masters, Goldgaber D, Dennis D. Cunningham, William E. Van Nostrand, C. J. Gibbs, D. Carleton Gajdusek, Lee J. Martin, Jiri G. Safar, Paul Brown, W. F. Odenwald, Donald E. Schmechel, Bruce D. Trapp, Linda C. Cork, Cooduvalli S. Shashikant, Axel Unterbeck, Lary C. Walker, Konrad Beyreuther, Edward H. Koo, Lev G. Goldfarb
Publikováno v:
Brain Research Reviews. 16:83-114
Autor:
Richard Bayney, Sangram S. Sisodia, Axel Unterbeck, Donald L. Price, Linda C. Cork, Edward H. Koo
Publikováno v:
Neuron. 4:97-104
Senile plaques are a characteristic feature in brains of individuals with Alzheimer's disease (AD) and aged monkeys. The principal component of amyloid in senile plaques is β/A4, a peptide derived from a larger amyloid precursor protein (APP). To da
Autor:
Christopher J. Leonard, Caryn Gunwaldsen, Bozena Bugaj-Gaweda, Xiaonan Xin, Michael De Vivo, Chengjun Deng, Daguang Wang, Axel Unterbeck, Yinghe Hu, May Kwan
Publikováno v:
Cellular signalling. 15(9)
We report here the cloning and characterization of two novel PDE4D isoforms, PDE4D6 and PDE4D7. PDE4D6 is a supershort form and PDE4D7 a long form of PDE4D. In addition, we have identified another novel long-form variant, PDE4D8, in silico. Like othe
Autor:
S. Heald, Robert N. Dreyer, Paul P. Tamburini, Michael E. Kamarck, Richard Bayney, Axel Unterbeck, Alice Lee, Lisa J. Hammond, Robert F. Tilton, Gary Davis, Ramabhadran Triprayar
Publikováno v:
Biochemistry. 30(43)
Certain precursor proteins (APP751 and APP770) of the amyloid beta-protein (AP) present in Alzheimer's disease contain a Kunitz-type serine protease inhibitor domain (APPI). In this study, the domain is obtained as a functional inhibitor through both
Autor:
John E. Butler, Axel Unterbeck, Gert Gruenewaldt, Paul Rounding, Thomas Weinhrauch, Rainer Groß
Publikováno v:
Angewandte Chemie. 103:341-342
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biology. 10(2-3)
Alzheimer's disease results from the degeneration of neurons. Degenerating nerve cells express atypical proteins, and amyloid is deposited. We suggest that some of these events are strongly influenced by genetic factors and age. Animal models should