Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Axel Seher"'
Autor:
Anna Chiara Wünsch, Elena Ries, Sina Heinzelmann, Andrea Frabschka, Peter Christoph Wagner, Theresa Rauch, Corinna Koderer, Mohamed El-Mesery, Julian Manuel Volland, Alexander Christian Kübler, Stefan Hartmann, Axel Seher
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 6, Pp 4557-4573 (2023)
In recent years, various forms of caloric restriction (CR) and amino acid or protein restriction (AAR or PR) have shown not only success in preventing age-associated diseases, such as type II diabetes and cardiovascular diseases, but also potential f
Externí odkaz:
https://doaj.org/article/a6efcf4e5fb74eba82a951acc96392fc
Autor:
Julian Manuel Volland, Johannes Kaupp, Werner Schmitz, Anna Chiara Wünsch, Julia Balint, Marc Möllmann, Mohamed El-Mesery, Kyra Frackmann, Leslie Peter, Stefan Hartmann, Alexander Christian Kübler, Axel Seher
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9220 (2022)
All forms of restriction, from caloric to amino acid to glucose restriction, have been established in recent years as therapeutic options for various diseases, including cancer. However, usually there is no direct comparison between the different res
Externí odkaz:
https://doaj.org/article/89c6566ff90c4de8946a18cdc5c598f5
Autor:
Corinna Koderer, Werner Schmitz, Anna Chiara Wünsch, Julia Balint, Mohamed El-Mesery, Julian Manuel Volland, Stefan Hartmann, Christian Linz, Alexander Christian Kübler, Axel Seher
Publikováno v:
Cells, Vol 11, Iss 3, p 551 (2022)
Nonlimited proliferation is one of the most striking features of neoplastic cells. The basis of cell division is the sufficient presence of mass (amino acids) and energy (ATP and NADH). A sophisticated intracellular network permanently measures the m
Externí odkaz:
https://doaj.org/article/ed68f6be026747a5acf9e628ff8907c8
Autor:
Werner Schmitz, Elena Ries, Corinna Koderer, Maximilian Friedrich Völter, Anna Chiara Wünsch, Mohamed El-Mesery, Kyra Frackmann, Alexander Christian Kübler, Christian Linz, Axel Seher
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11630 (2021)
Methionine restriction (MetR) is an efficient method of amino acid restriction (AR) in cells and organisms that induces low energy metabolism (LEM) similar to caloric restriction (CR). The implementation of MetR as a therapy for cancer or other disea
Externí odkaz:
https://doaj.org/article/bab2b723715640b5ba9b5810747da43b
Autor:
Werner Schmitz, Corinna Koderer, Mohamed El-Mesery, Sebastian Gubik, Rene Sampers, Anton Straub, Alexander Christian Kübler, Axel Seher
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 3039 (2021)
Since Otto Warburg reported in 1924 that cancer cells address their increased energy requirement through a massive intake of glucose, the cellular energy level has offered a therapeutic anticancer strategy. Methionine restriction (MetR) is one of the
Externí odkaz:
https://doaj.org/article/023ab5312c57490bb17c1dc07c3c5c54
Autor:
Verena Boschert, Jonas Teusch, Anwar Aljasem, Philipp Schmucker, Nicola Klenk, Anton Straub, Max Bittrich, Axel Seher, Christian Linz, Urs D. A. Müller-Richter, Stefan Hartmann
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8770 (2020)
Head and neck squamous cell carcinoma (HNSCC) is a widespread disease with a low survival rate and a high risk of recurrence. Nowadays, immune checkpoint inhibitor (ICI) treatment is approved for HNSCC as a first-line treatment in recurrent and metas
Externí odkaz:
https://doaj.org/article/8044eb9612ad4cdf80438c2edb5c916d
Autor:
Verena Boschert, Nicola Klenk, Alexander Abt, Sudha Janaki Raman, Markus Fischer, Roman C. Brands, Axel Seher, Christian Linz, Urs D. A. Müller-Richter, Thorsten Bischler, Stefan Hartmann
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 471 (2020)
Head and neck squamous cell carcinoma (HNSCC) is known to overexpress a variety of receptor tyrosine kinases, such as the HGF receptor Met. Like other malignancies, HNSCC involves a mutual interaction between the tumor cells and surrounding tissues a
Externí odkaz:
https://doaj.org/article/cade972cde004f18919cf02eb044ef0e
Autor:
Axel Seher, Charlotte Lagler, Thorsten Stühmer, Urs Dietmar Achim Müller-Richter, Alexander Christian Kübler, Walter Sebald, Thomas Dieter Müller, Joachim Nickel
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0174884 (2017)
Multiple myeloma (MM) represents a haematological cancer characterized by the pathological hyper proliferation of antibody-producing B-lymphocytes. Patients typically suffer from kidney malfunction and skeletal disorders. In the context of MM, the tr
Externí odkaz:
https://doaj.org/article/3990fafe94fc45b0bc0c29833b01d56b
Autor:
Charlotte Lagler, Mohamed El-Mesery, Alexander Christian Kübler, Urs Dietmar Achim Müller-Richter, Thorsten Stühmer, Joachim Nickel, Thomas Dieter Müller, Harald Wajant, Axel Seher
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185720 (2017)
Multiple myeloma (MM), a malignancy of the bone marrow, is characterized by a pathological increase in antibody-producing plasma cells and an increase in immunoglobulins (plasmacytosis). In recent years, bone morphogenetic proteins (BMPs) have been r
Externí odkaz:
https://doaj.org/article/b465a25915f44227a96502f6fecae221
Autor:
Mario Joachim Johannes Scheurer, Roman Camillus Brands, Mohamed El-Mesery, Stefan Hartmann, Urs Dietmar Achim Müller-Richter, Alexander Christian Kübler, Axel Seher
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1306 (2019)
Inflammation is a central aspect of tumour biology and can contribute significantly to both the origination and progression of tumours. The NFκB pathway is one of the most important signal transduction pathways in inflammation and is, therefore, an
Externí odkaz:
https://doaj.org/article/d43f909d89e645048d6c76967b1854da