Zobrazeno 1 - 10
of 520
pro vyhledávání: '"Axel Schambach"'
Autor:
Larissa Nassauer, Hinrich Staecker, Peixin Huang, Bryan Renslo, Madeleine Goblet, Jennifer Harre, Athanasia Warnecke, Juliane W. Schott, Michael Morgan, Melanie Galla, Axel Schambach
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102157- (2024)
Cisplatin is a highly effective chemotherapeutic agent, but it can cause sensorineural hearing loss (SNHL) in patients. Cisplatin-induced ototoxicity is closely related to the accumulation of reactive oxygen species (ROS) and subsequent death of hair
Externí odkaz:
https://doaj.org/article/fa09f49038244138abbce7ed6e21d4c8
Publikováno v:
HardwareX, Vol 17, Iss , Pp e00509- (2024)
This paper aims to provide the details for making affordable single and multichannel liquid aspirators for wet labs. A liquid aspirator is a basic laboratory device that can cost several hundred Euros. We present a < €25 3D print solution that perf
Externí odkaz:
https://doaj.org/article/0b2631ed63e14d0ba784dcec19e84a28
Autor:
Guorong Sun, Kai Alexander Kropp, Marieluise Kirchner, Nina Plückebaum, Anton Selich, Manutea Serrero, Akshay Dhingra, Jorge Rubén Cabrera, Birgit Ritter, Rudolf Bauerfeind, Emanuel Wyler, Markus Landthaler, Axel Schambach, Beate Sodeik, Philipp Mertins, Abel Viejo-Borbolla
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT The highly prevalent herpes simplex virus type 1 (HSV-1) causes a range of diseases, including cold sores, blinding keratitis, and life-threatening encephalitis. HSV-1 initially replicates in epithelial cells, enters the peripheral nervous s
Externí odkaz:
https://doaj.org/article/b03f18e16aa44eca859b26cb7c0b5163
Autor:
Anton Selich, Jenni Fleischauer, Tina Roepke, Luisa Weisskoeppel, Melanie Galla, Constantin von Kaisenberg, Ulrich A. Maus, Axel Schambach, Michael Rothe
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background Mesenchymal stromal cells (MSCs) are excessively investigated in the context of inflammation-driven diseases, but the clinical results are often moderate. MSCs are naturally activated by inflammatory signals, which lead to the sec
Externí odkaz:
https://doaj.org/article/7c94c09531e44c77b8ccdeeb9ca36465
Autor:
Antonella L. Bastone, Violetta Dziadek, Philipp John-Neek, Friederike Mansel, Jenni Fleischauer, Eric Agyeman-Duah, Dirk Schaudien, Oliver Dittrich-Breiholz, Adrian Schwarzer, Axel Schambach, Michael Rothe
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 515-533 (2023)
Safety assessment in retroviral vector-mediated gene therapy remains challenging. In clinical trials for different blood and immune disorders, insertional mutagenesis led to myeloid and lymphoid leukemia. We previously developed the In Vitro Immortal
Externí odkaz:
https://doaj.org/article/4d961949250f4d17b1e74ea409031a0e
Autor:
Nadja Seltrecht, Matthias Hardtke-Wolenski, Konstantinos Iordanidis, Danny Jonigk, Melanie Galla, Axel Schambach, Laura Elisa Buitrago-Molina, Heiner Wedemeyer, Fatih Noyan, Elmar Jaeckel
Publikováno v:
Cells, Vol 13, Iss 14, p 1216 (2024)
Background: Solid organ transplantation is hindered by immune-mediated chronic graft dysfunction and the side effects of immunosuppressive therapy. Regulatory T cells (Tregs) are crucial for modulating immune responses post-transplantation; however,
Externí odkaz:
https://doaj.org/article/4429a14562044937a921119004b57d0a
Autor:
Gesine Hansen, Axel Schambach, Christine S Falk, Arnold Kloos, Michael Morgan, Shifaa M. Abdin, Daniela Paasch, Nico Lachmann, Marco Carvalho Oliveira, Mi-Sun Jang, Mania Ackermann, Andriana Stamopoulou, Philipp J Mroch, Constantin S von Kaisenberg, Michael Heuser, Thomas Moritz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Background Macrophages have recently become attractive therapeutics in cancer immunotherapy. The potential of macrophages to infiltrate and influence solid malignancies makes them promising targets for the chimeric antigen receptor (CAR) technology t
Externí odkaz:
https://doaj.org/article/95887552adbe4426b971a8b340ad3b4a
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/49ec8623cbaa45d495073e396227ef68
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/3bf1d7e36f2b41078d40c9e6bffc0c3e
Autor:
Amr H. Saleh, Michael Rothe, Dwayne L. Barber, William M. McKillop, Graeme Fraser, Chantal F. Morel, Axel Schambach, Christiane Auray-Blais, Michael L. West, Aneal Khan, Daniel H. Fowler, C. Anthony Rupar, Ronan Foley, Jeffrey A. Medin, Armand Keating
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 262-271 (2023)
The safety and efficacy of lentivirus-mediated gene therapy was recently demonstrated in five male patients with Fabry disease—a rare X-linked lysosomal storage disorder caused by GLA gene mutations that result in multiple end-organ complications.
Externí odkaz:
https://doaj.org/article/94ca546755434fd5983165124cd0e623