Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Axel Sandmann"'
Publikováno v:
Journal of Biotechnology. 135:255-261
Myxobacteria are proficient producers of biologically active secondary metabolites. However, efforts to exploit these natural products for the development of new therapeutics and agrochemicals are frequently hampered by low production levels. We desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0105f0f862869092161f89e361a7eecf
https://doi.org/10.1016/j.jbiotec.2008.05.001
https://doi.org/10.1016/j.jbiotec.2008.05.001
Autor:
Iain R. Challis, Lindsey Low, Peter F. Leadlay, Rolf Müller, Barrie Wilkinson, Steven G. Kendrew, Jose Garcia-Bernardo, Hans-Jürgen Hecht, Hrvoje Petković, Axel Sandmann, Barbara Silakowski, Enej Kuščer, Nicola Beeston
Publikováno v:
Org. Biomol. Chem.. 6:500-506
The production of epothilone mixtures is a direct consequence of the substrate tolerance of the module 3 acyltransferase (AT) domain of the epothilone polyketide synthase (PKS) which utilises both malonyl- and methylmalonyl-CoA extender units. Partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1bd270b9daf2d8746edb26dc61b505
https://doi.org/10.1039/b714804f
https://doi.org/10.1039/b714804f
Autor:
Axel Sandmann, Rolf Müller, Elke Dittmann, Jeroen S. Dickschat, Holger Jenke-Kodama, Brigitte Kunze
Publikováno v:
Angewandte Chemie International Edition. 46:2712-2716
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1747ca881ff6c7d3c4baee13903ebc8
https://doi.org/10.1002/anie.200603513
https://doi.org/10.1002/anie.200603513
Autor:
Axel Sandmann, Rolf Müller, Holger Jenke-Kodama, Jeroen S. Dickschat, Elke Dittmann, Brigitte Kunze
Publikováno v:
Angewandte Chemie. 119:2768-2772
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edb437f6a03135b937c34c1c3cfe683d
https://doi.org/10.1002/ange.200603513
https://doi.org/10.1002/ange.200603513
Publikováno v:
Molecular Biology and Evolution. 22:2027-2039
Polyketide synthases (PKS) perform a stepwise biosynthesis of diverse carbon skeletons from simple activated carboxylic acid units. The products of the complex pathways possess a wide range of pharmaceutical properties, including antibiotic, antitumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefacbe9aff6bdfe13738c7054e4ab00
https://doi.org/10.1093/molbev/msi193
https://doi.org/10.1093/molbev/msi193
Autor:
Maren Kopp, Axel Sandmann, Frank Gross, Klaus Gerth, Herbert Irschik, Rolf Müller, Olena Perlova
Publikováno v:
Journal of Biotechnology. 107:29-40
Myxobacteria increasingly gain attention as a source of bioactive natural products. The genus Sorangium produces almost half of the secondary metabolites isolated from these microorganisms. Nevertheless, genetic systems for Sorangium strains are poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46d4548fd304b5ccd616c7a9982310d
https://doi.org/10.1016/j.jbiotec.2003.09.013
https://doi.org/10.1016/j.jbiotec.2003.09.013
Publikováno v:
Molecular BioSystems. 7:3308
The aurachins are a family of secondary metabolites, with the main members aurachin A, B, C, and D, produced by the myxobacterium Stigmatella aurantiaca Sg a15. These isoprenoid quinoline alkaloids are classified as A-type or C-type aurachins accordi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebab7540278314d891ce37877341b171
https://doi.org/10.1039/c1mb05328k
https://doi.org/10.1039/c1mb05328k
Publikováno v:
Chemistry & Biology. (8):1071-1079
Myxobacteria are well known for their biosynthetic potential, especially for the production of cytotoxic compounds with potential anticancer activities. The tubulysins are currently in preclinical development. They are produced in very low quantities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16536c43a9561fbbc46c2f8377372f61