Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Axel R, Concepcion"'
Autor:
Serap Erdogmus, Axel R. Concepcion, Megumi Yamashita, Ikjot Sidhu, Anthony Y. Tao, Wenyi Li, Pedro P. Rocha, Bonnie Huang, Ralph Garippa, Boram Lee, Amy Lee, Johannes W. Hell, Richard S. Lewis, Murali Prakriya, Stefan Feske
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The function of voltage-gated calcium channels in T cells is not well understood and controversial. Here the authors report that a regulatory beta subunit of voltage-gated calcium channels regulates T cell function despite no evidence that these chan
Externí odkaz:
https://doaj.org/article/5b75fb8dc4614e899839c3361f59e74d
Autor:
Sascha Kahlfuss, Ulrike Kaufmann, Axel R Concepcion, Lucile Noyer, Dimitrius Raphael, Martin Vaeth, Jun Yang, Priya Pancholi, Mate Maus, James Muller, Lina Kozhaya, Alireza Khodadadi‐Jamayran, Zhengxi Sun, Patrick Shaw, Derya Unutmaz, Peter B Stathopulos, Cori Feist, Scott B Cameron, Stuart E Turvey, Stefan Feske
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 8, Pp 1-25 (2020)
Abstract Immunity to fungal infections is mediated by cells of the innate and adaptive immune system including Th17 cells. Ca2+ influx in immune cells is regulated by stromal interaction molecule 1 (STIM1) and its activation of the Ca2+ channel ORAI1
Externí odkaz:
https://doaj.org/article/5dea67d69b0a4240ad6b7dfd0ac39c79
Autor:
Jon Celay, Teresa Lozano, Axel R. Concepcion, Elena Beltrán, Francesc Rudilla, María José García-Barchino, Eloy F. Robles, Obdulia Rabal, Irene de Miguel, Carlos Panizo, Noelia Casares, Julen Oyarzabal, Jesús Prieto, Juan F. Medina, Juan José Lasarte, José Ángel Martínez-Climent
Publikováno v:
Haematologica, Vol 103, Iss 6 (2018)
Regulatory T (Treg) cells can weaken antitumor immune responses, and inhibition of their function appears to be a promising therapeutic approach in cancer patients. Mice with targeted deletion of the gene encoding the Cl−/HCO3− anion exchanger AE
Externí odkaz:
https://doaj.org/article/25a1ce682baf49a699ef7d52c130573e
Autor:
Serap, Erdogmus, Axel R, Concepcion, Megumi, Yamashita, Ikjot, Sidhu, Anthony Y, Tao, Wenyi, Li, Pedro P, Rocha, Bonnie, Huang, Ralph, Garippa, Boram, Lee, Amy, Lee, Johannes W, Hell, Richard S, Lewis, Murali, Prakriya, Stefan, Feske
Publikováno v:
Nature communications. 13(1)
TCR stimulation triggers Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5215cbf2839fa8680807215819844d08
https://pubmed.ncbi.nlm.nih.gov/35700266
https://pubmed.ncbi.nlm.nih.gov/35700266
Publikováno v:
Frontiers in Physiology, Vol 4 (2014)
The Cl-/HCO3- anion exchanger 2 (AE2) is known to be involved in intracellular pH (pHi) regulation and transepithelial acid-base transport. Early studies showed that AE2 gene expression is reduced in liver biopsies and blood mononuclear cells from pa
Externí odkaz:
https://doaj.org/article/5fe40f915d6d44ada2f2b561056be6a1
Autor:
Axel R, Concepcion, Larry E, Wagner, Jingjie, Zhu, Anthony Y, Tao, Jun, Yang, Alireza, Khodadadi-Jamayran, Yin-Hu, Wang, Menghan, Liu, Rebecca E, Rose, Drew R, Jones, William A, Coetzee, David I, Yule, Stefan, Feske
Publikováno v:
Nature immunology. 23(2)
The volume-regulated anion channel (VRAC) is formed by LRRC8 proteins and is responsible for the regulatory volume decrease (RVD) after hypotonic cell swelling. Besides chloride, VRAC transports other molecules, for example, immunomodulatory cyclic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d70ea379ffa47c68558569a6962a71d
https://pubmed.ncbi.nlm.nih.gov/35105986
https://pubmed.ncbi.nlm.nih.gov/35105986
Autor:
Francisco J, Aulestia, Johnny, Groeling, Guilherme H S, Bomfim, Veronica, Costiniti, Vinu, Manikandan, Ariya, Chaloemtoem, Axel R, Concepcion, Yi, Li, Larry E, Wagner, Youssef, Idaghdour, David I, Yule, Rodrigo S, Lacruz
Publikováno v:
Science signaling. 13(619)
Fluoride ions are highly reactive, and their incorporation in forming dental enamel at low concentrations promotes mineralization. In contrast, excessive fluoride intake causes dental fluorosis, visually recognizable enamel defects that can increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9999eca6e7561628a88faae3dfb3e6f9
https://pubmed.ncbi.nlm.nih.gov/32071168
https://pubmed.ncbi.nlm.nih.gov/32071168
Autor:
Axel R. Concepcion, Francisco J. Aulestia, Rodrigo S. Lacruz, Ariya Chaloemtoem, Vinu Manikandan, Johnny Groeling, Youssef Idaghdour, Larry E. Wagner, Yi Li, Veronica Costiniti, Guilherme Henrique Souza Bomfim, David I. Yule
Publikováno v:
Science Signaling. 13
Fluoride ions are highly reactive, and their incorporation in forming dental enamel at low concentrations promotes mineralization. In contrast, excessive fluoride intake causes dental fluorosis, visually recognizable enamel defects that can increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b22324ce8c6a6daf719d5ffee216a2dc
https://doi.org/10.1126/scisignal.aay0086
https://doi.org/10.1126/scisignal.aay0086
Autor:
Axel R. Concepcion, Stefan Feske
Publikováno v:
Cell Calcium. 63:53-59
Store-operated Ca2+ entry (SOCE) is a conserved mechanism of Ca2+ influx that regulates Ca2+ signaling in many cell types. SOCE is activated by depletion of endoplasmic reticulum (ER) Ca2+ stores in response to physiological agonist stimulation. Afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f438e706f7a38eede2f1678ab11955
https://doi.org/10.1016/j.ceca.2016.12.004
https://doi.org/10.1016/j.ceca.2016.12.004
Autor:
Mate Maus, Ulrike Kaufmann, Stefan Feske, Derya Unutmaz, Lucile Noyer, Dimitrius Raphael, Sascha Kahlfuss, James E. Muller, Patrick J. Shaw, Jun Yang, Zhengxi Sun, Lina Kozhaya, Cori Feist, Priya Pancholi, Alireza Khodadadi-Jamayran, Stuart E. Turvey, Martin Vaeth, Axel R. Concepcion, Scott B. Cameron, Peter B. Stathopulos
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 8, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 8, Pp n/a-n/a (2020)
Immunity to fungal infections is mediated by cells of the innate and adaptive immune system including Th17 cells. Ca2+ influx in immune cells is regulated by stromal interaction molecule 1 (STIM1) and its activation of the Ca2+ channel ORAI1. We here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6eb77c3b87b7ef580201e37654528e
https://pubmed.ncbi.nlm.nih.gov/32609955
https://pubmed.ncbi.nlm.nih.gov/32609955