Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Axel Pagenstecher"'
Autor:
Johanna K. Rickel, Daria Zeeb, Susanne Knake, Hans Urban, Jürgen Konczalla, Katharina J. Weber, Pia S. Zeiner, Axel Pagenstecher, Elke Hattingen, André Kemmling, Emmanouil Fokas, Sebastian Adeberg, Robert Wolff, Martin Sebastian, Tillmann Rusch, Michael W. Ronellenfitsch, Katja Menzler, Lena Habermehl, Leona Möller, Marcus Czabanka, Christopher Nimsky, Lars Timmermann, Christian Grefkes, Joachim P. Steinbach, Felix Rosenow, Leena Kämppi, Adam Strzelczyk
Publikováno v:
Neurological Research and Practice, Vol 6, Iss 1, Pp 1-14 (2024)
Abstract Objective Brain tumors and metastases account for approximately 10% of all status epilepticus (SE) cases. This study described the clinical characteristics, treatment, and short- and long-term outcomes of this population. Methods This retros
Externí odkaz:
https://doaj.org/article/18c8e02e7acb409caf7bcc820f903731
Autor:
Rhonda L. McFleder, Anastasiia Makhotkina, Janos Groh, Ursula Keber, Fabian Imdahl, Josefina Peña Mosca, Alina Peteranderl, Jingjing Wu, Sawako Tabuchi, Jan Hoffmann, Ann-Kathrin Karl, Axel Pagenstecher, Jörg Vogel, Andreas Beilhack, James B. Koprich, Jonathan M. Brotchie, Antoine-Emmanuel Saliba, Jens Volkmann, Chi Wang Ip
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson’s disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understa
Externí odkaz:
https://doaj.org/article/64b3f60bf6a74cc880822e0307d481d0
Autor:
Joel Wessendorf, Michael Scheschenja, Moritz B. Bastian, Alexander M. König, Axel Pagenstecher, Frederik Helmprobst, Malte Buchholz, Marina Tatura, Jarmila Jedelská, Andreas H. Mahnken
Publikováno v:
European Radiology Experimental, Vol 7, Iss 1, Pp 1-8 (2023)
Abstract Background We evaluated the feasibility of a chick chorioallantoic membrane (CAM) tumor model for preclinical research on tumor radiofrequency ablation (RFA). Methods Fertilized chicken eggs were incubated and divided into five cohorts: RFA
Externí odkaz:
https://doaj.org/article/f4db89f287f44be18b4e01a37b79a08c
Autor:
Kai Zhao, Madita Braun, Leonie Meyer, Katharina Otte, Hartmann Raifer, Frederik Helmprobst, Vincent Möschl, Axel Pagenstecher, Hans Urban, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jelena Pesek, Bernhard Watzer, Wolfgang A. Nockher, R. Verena Taudte, Andreas Neubauer, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch
Publikováno v:
Cells, Vol 13, Iss 7, p 632 (2024)
Adjuvant treatment for Glioblastoma Grade 4 with Temozolomide (TMZ) inevitably fails due to therapeutic resistance, necessitating new approaches. Apoptosis induction in GB cells is inefficient, due to an excess of anti-apoptotic XPO1/Bcl-2-family pro
Externí odkaz:
https://doaj.org/article/7779d674787040b28c0fded66adc1aba
Autor:
Maren Nicole Stillger, Chia-Yi Chen, Zon Weng Lai, Mujia Li, Agnes Schäfer, Axel Pagenstecher, Christopher Nimsky, Jörg Walter Bartsch, Oliver Schilling
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-23 (2023)
Abstract Background Glioblastoma multiforme (GBM) is characterized by an unfavorable prognosis for patients affected. During standard-of-care chemotherapy using temozolomide (TMZ), tumors acquire resistance thereby causing tumor recurrence. Thus, dec
Externí odkaz:
https://doaj.org/article/bb7e3b7c0e0f41668975e51567ee9a33
Autor:
Kai Zhao, Pilar Calero-Pérez, Miriam H. A. Bopp, Vincent Möschl, Axel Pagenstecher, Marta Mulero-Acevedo, Mario Vázquez, Carlos Barcia, Carles Arús, Christopher Nimsky, Tillmann Rusch, Jörg W. Bartsch, Ana Paula Candiota
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17628 (2023)
The tumor microenvironment in glioblastoma (GB) is considered to be “cold”, i.e., the fraction of cytotoxic T cells, for instance, is low. Instead, macrophages are the major immune cell population in GB, which stem either from tissue response (re
Externí odkaz:
https://doaj.org/article/c45c798956f541c28aa98a2d1cd8b57e
Autor:
Nastasja Merle, Sabrina Elmshäuser, Florian Strassheimer, Michael Wanzel, Alexander M. König, Julianne Funk, Michelle Neumann, Katharina Kochhan, Frederik Helmprobst, Axel Pagenstecher, Andrea Nist, Marco Mernberger, André Schneider, Thomas Braun, Tilman Borggrefe, Rajkumar Savai, Oleg Timofeev, Thorsten Stiewe
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-22 (2022)
Abstract Background In vivo gene editing of somatic cells with CRISPR nucleases has facilitated the generation of autochthonous mouse tumors, which are initiated by genetic alterations relevant to the human disease and progress along a natural timeli
Externí odkaz:
https://doaj.org/article/d980d18d5f1b484f966f534df0c944fb
Autor:
Christiane D. Much, Barbara S. Sendtner, Konrad Schwefel, Eric Freund, Sander Bekeschus, Oliver Otto, Axel Pagenstecher, Ute Felbor, Matthias Rath, Stefanie Spiegler
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Cerebral cavernous malformations are slow-flow thrombi-containing vessels induced by two-step inactivation of the CCM1, CCM2 or CCM3 gene within endothelial cells. They predispose to intracerebral bleedings and focal neurological deficits. Our unders
Externí odkaz:
https://doaj.org/article/6235fddf84474db1b2750edac3925c4f
Autor:
Yesim Verel-Yilmaz, Juan Pablo Fernández, Agnes Schäfer, Sheila Nevermann, Lena Cook, Norman Gercke, Frederik Helmprobst, Christian Jaworek, Elke Pogge von Strandmann, Axel Pagenstecher, Detlef K. Bartsch, Jörg W. Bartsch, Emily P. Slater
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Due to a grim prognosis, there is an urgent need to detect pancreatic ductal adenocarcinoma (PDAC) prior to metastasis. However, reliable diagnostic imaging methods or biomarkers for PDAC or its precursor lesions are still scarce. ADAM8, a metallopro
Externí odkaz:
https://doaj.org/article/c3410811784b46d082946a8aab0a1d76
Autor:
Stefanie Beck-Wödl, Klaus Harzer, Marc Sturm, Rebecca Buchert, Olaf Rieß, Hans-Dieter Mennel, Elisabeth Latta, Axel Pagenstecher, Ursula Keber
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Homozygous mutation of TBC1 domain-containing kinase (TBCK) is the cause of a very recently defined severe childhood disorder, which is characterized by severe hypotonia, global developmental delay, intellectual disability, epilepsy, charact
Externí odkaz:
https://doaj.org/article/940ccc65bbc64518b8c463bd8eef7ec1