Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Axel Neu"'
Autor:
Anna Worthmann, Julius Ridder, Sharlaine Y. L. Piel, Ioannis Evangelakos, Melina Musfeldt, Hannah Voß, Marie O’Farrell, Alexander W. Fischer, Sangeeta Adak, Monica Sundd, Hasibullah Siffeti, Friederike Haumann, Katja Kloth, Tatjana Bierhals, Markus Heine, Paul Pertzborn, Mira Pauly, Julia-Josefine Scholz, Suman Kundu, Marceline M. Fuh, Axel Neu, Klaus Tödter, Maja Hempel, Uwe Knippschild, Clay F. Semenkovich, Hartmut Schlüter, Joerg Heeren, Ludger Scheja, Christian Kubisch, Christian Schlein
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Dietary polyunsaturated fatty acids (PUFA) are increasingly recognized for their health benefits, whereas a high production of endogenous fatty acids – a process called de novo lipogenesis (DNL) - is closely linked to metabolic diseases. D
Externí odkaz:
https://doaj.org/article/d4a6b8efd8424ceaa3b39a71f53879ef
Autor:
Nicole von Steinbuechel, Marina Zeldovich, Dagmar Timmermann, Ugne Krenz, Inga K. Koerte, Michaela V. Bonfert, Steffen Berweck, Matthias Kieslich, Marlene Henrich, Knut Brockmann, Anna Buchheim, Maike Roediger, Michael Lendt, Christian Auer, Axel Neu, Alexander Kaiser, Joenna Driemeyer, Sven Greving, Ulrike Wartemann, Daniel Pinggera, Claudius Thomé, Joachim Suss, Holger Muehlan, Katrin Cunitz
Publikováno v:
Children, Vol 11, Iss 4, p 438 (2024)
Until recently, no disease-specific health-related quality of life (HRQoL) questionnaire existed for pediatric traumatic brain injuries (TBIs). In this revalidation study, the psychometric properties and the validity of the 35-item QOLIBRI-KID/ADO qu
Externí odkaz:
https://doaj.org/article/b03a113905914ecaafb1bca6e5c1b32f
Autor:
Katja Kloth, Matthis Synofzik, Christoph Kernstock, Simone Schimpf-Linzenbold, Frank Schuettauf, Axel Neu, Bernd Wissinger, Nicole Weisschuh
Publikováno v:
BMC Medical Genetics, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Reports on autosomal recessive optic atrophy (arOA) are sparse and so far, only one gene has been specifically associated with non-syndromic arOA, namely TMEM126A. To date, all reports of pathogenic TMEM126A variants are from affe
Externí odkaz:
https://doaj.org/article/5813e9f732694587b14ab12ef7ff9bfc
Autor:
Malte Stockebrand, Ali Sasani, Devashish Das, Sönke Hornig, Irm Hermans-Borgmeyer, Hannah A. Lake, Dirk Isbrandt, Craig A. Lygate, Arend Heerschap, Axel Neu, Chi-Un Choe
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Creatine serves as fast energy buffer in organs of high-energy demand such as brain and skeletal muscle. L-Arginine:glycine amidinotransferase (AGAT) and guanidinoacetate N-methyltransferase are responsible for endogenous creatine synthesis. Subseque
Externí odkaz:
https://doaj.org/article/80d7c7fb74354e779da9990f12cd48c5
Autor:
Axel Neu, Henrike Neuhoff, Gerhard Trube, Susanne Fehr, Kurt Ullrich, Jochen Roeper, Dirk Isbrandt
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 2, Pp 298-307 (2002)
Guanidinoacetate methyltransferase (GAMT) deficiency is an autosomal recessively inherited disorder of creatine biosynthesis. The disease occurs in early life with developmental delay or arrest and several neurological symptoms, e.g., seizures and dy
Externí odkaz:
https://doaj.org/article/dbfa6c5e3c844c6a8a2d99077296dc64
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e700 (2007)
Homeostatic plasticity is thought to be important in preventing neuronal circuits from becoming hyper- or hypoactive. However, there is little information concerning homeostatic mechanisms following in vivo manipulations of activity levels. We invest
Externí odkaz:
https://doaj.org/article/ff89db6a62524dc98b157573910ee995
Autor:
Anna Worthmann, Julius Ridder, Sharlaine Piel, Ioannis Evangelakos, Melina Musfeldt, Hannah Voß, Marie O'Farell, Alexander Fischer, Sangeeta Adak, Monica Sundd, Hasibullah Siffeti, Friederike Haumann, Katja Kloth, Tatjana Bierhals, Markus Heine, Paul Pertzborn, Mira Pauly, Julia-Josefine Scholz, Suman Kundu, Manka Fuh, Axel Neu, Klaus Tödter, Maja Hempel, Uwe Knippschild, Clay Semenkovich, Hartmut Schlüter, Joerg Heeren, Ludger Scheja, Christian Kubisch, Christian Schlein
Metabolic diseases are closely linked to aberrant synthesis of endogenous fatty acids in the liver, called de novo lipogenesis (DNL), which is mediated by the enzyme fatty acid synthase (FASN). The composition of complex lipids consists of saturated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::173c56b8ee8d5bd0e2d00d0c857cbb38
https://doi.org/10.21203/rs.3.rs-1008467/v3
https://doi.org/10.21203/rs.3.rs-1008467/v3
Autor:
Christian Schlein, Anna Worthmann, Sharlaine Piel, Alexander Fischer, Marie O'Farell, Sangeeta Adak, Katja Kloth, Monica Sundd, Hasibullah Siffeti, Melina Musfeldt, Tatjana Bierhals, Markus Heine, Mira Pauly, Friederike Haumann, Suman Kundu, Manka Fuh, Axel Neu, Carine Beysen, Paul Pertzborn, Hartmut Schlüter, Uwe Knippschild, Klaus Tödter, Maja Hempel, Clay Semenkovich, Joerg Heeren, Ludger Scheja, Christian Kubisch
Metabolic diseases such as obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis (NASH) are closely linked to aberrant synthesis of endogenous fatty acids in the liver, called de novo lipogenesis, which is mediated by the enzyme fatty a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74d6c471da1e31b532d4ec756efab8b
https://doi.org/10.21203/rs.3.rs-1008467/v2
https://doi.org/10.21203/rs.3.rs-1008467/v2
Publikováno v:
Abstracts of the 46th Annual Meeting of the Society for Neuropediatrics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f56e566779e876fdd2b2fab2b1bb3d4
https://doi.org/10.1055/s-0041-1739601
https://doi.org/10.1055/s-0041-1739601
Autor:
Chi-Un Choe, Christian Gerloff, Soenke Hornig, Axel Neu, Dirk Isbrandt, D. Tsikas, Ali Sasani, Edzard Schwedhelm
Publikováno v:
Amino Acids
Amino acids 52(6-7), 1067-1069 (2020). doi:10.1007/s00726-020-02865-w
Amino acids 52(6-7), 1067-1069 (2020). doi:10.1007/s00726-020-02865-w
Our study evaluated the effect of creatine and homoarginine in AGAT- and GAMT-deficient mice after simvastatin exposure. Balestrino and Adriano suggest that guanidinoacetate might explain the difference between AGAT- and GAMT-deficient mice in simvas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec191946a519554760ce53c5c8647712
https://doi.org/10.1007/s00726-020-02865-w
https://doi.org/10.1007/s00726-020-02865-w