Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Axel M. Küchler"'
Autor:
Amilton M Fernandes, Sarah R Herlofsen, Tommy A Karlsen, Axel M Küchler, Yngvar Fløisand, Jan E Brinchmann
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62994 (2013)
Lesions of hyaline cartilage do not heal spontaneously, and represent a therapeutic challenge. In vitro engineering of articular cartilage using cells and biomaterials may prove to be the best solution. Patients with osteoarthritis (OA) may require t
Externí odkaz:
https://doaj.org/article/f3e5029ee0bf4c3fb06385e82c66b014
Autor:
Amine Kamen, Olav Sundnes, Axel M. Küchler, Reidunn J Edelmann, Mari Kaarbø, Danh Phung, Fredrik Müller, Lars La Cour Poulsen, Guttorm Haraldsen, Johanna Hol, Tor Espen Stav-Noraas
IL-33, required for viral clearance by cytotoxic T cells, is generally expressed in vascular endothelial cells in healthy human tissues. We discovered that endothelial IL-33 expression was stimulated as a response to adenoviral transduction. This res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca41208e32b8bc5d53989361aac68d2
http://hdl.handle.net/10852/61967
http://hdl.handle.net/10852/61967
Autor:
Johanna Hol, Irina A. Udalova, Miriam Weiss, Kim S. Midwood, Monika Kasprzycka, Guttorm Haraldsen, Eirik Sundlisæter, Reidunn J Edelmann, Axel M. Küchler, Jon Sponheim
Publikováno v:
The American Journal of Pathology. 181:1099-1111
The molecular mechanisms that drive expression of the alarmin interleukin-33 (IL-33) in endothelial cells are unknown. Because nuclear IL-33 is a marker of endothelial cell quiescence (corroborated in this study by coexpression of cyclin-dependent ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8055618544e54159edda1190bfec8a29
https://doi.org/10.1016/j.ajpath.2012.06.003
https://doi.org/10.1016/j.ajpath.2012.06.003
Publikováno v:
Tissue Engineering Part A. 17:1003-1013
We have used a disc-shaped self-gelling alginate hydrogel as a scaffold for in vitro chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells. The comparison of monolayer cells and alginate embedded cells with or without diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16c2b5d59c2046f06d2d800eb1edbc4
https://doi.org/10.1089/ten.tea.2010.0499
https://doi.org/10.1089/ten.tea.2010.0499
Autor:
Jon Sponheim, Guttorm Haraldsen, Johanna Balogh, Monika Kasprzycka, Hogne Røed Nilsen, Jürgen Pollheimer, Morten H. Vatn, Dag R. Sorensen, Tamara Loos, Trine Olsen, Clara Hammarström, Axel M. Küchler
Publikováno v:
The American Journal of Pathology. 177:2804-2815
Interleukin-33 (IL-33) is a novel member of the interleukin-1 family that induces mucosal pathology in vivo and may drive fibrosis development and angiogenesis. To address its potential role in inflammatory bowel disease, we explored its tissue expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c389f89f2fb42b3c3695a282350b9f
https://doi.org/10.2353/ajpath.2010.100378
https://doi.org/10.2353/ajpath.2010.100378
Autor:
Inger Øynebråten, Johanna Hol, Finn-Eirik Johansen, Guttorm Haraldsen, Axel M. Küchler, Bjørn Dalhus
Publikováno v:
Journal of Biological Chemistry. 284:23532-23539
Sorting of proteins to Weibel-Palade bodies (WPB) of endothelial cells allows rapid regulated secretion of leukocyte-recruiting P-selectin and chemokines as well as procoagulant von Willebrand factor (VWF). Here we show by domain swap studies that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0229a863ea50f5aa3d843a72500874b
https://doi.org/10.1074/jbc.m900874200
https://doi.org/10.1074/jbc.m900874200
Autor:
Tatjana Piotrowski, Heiner Grandel, Muriel Rhinn, Nigel Holder, Klaus Lun, Gerd-Jörg Rauch, Paolo Sordino, Stephen W. Wilson, Robert Geisler, Corinne Houart, Michael Brand, Stefan Schulte-Merker, Axel M. Küchler
Publikováno v:
Development. 129:2851-2865
A number of studies have suggested that retinoic acid (RA) is an important signal for patterning the hindbrain, the branchial arches and the limb bud. Retinoic acid is thought to act on the posterior hindbrain and the limb buds at somitogenesis stage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c05ac3487695623d9a47e17c0625c7
https://doi.org/10.1242/dev.129.12.2851
https://doi.org/10.1242/dev.129.12.2851
Autor:
Inger, Øynebråten, Nicolas, Barois, Trygve, Bergeland, Axel M, Küchler, Oddmund, Bakke, Guttorm, Haraldsen
Publikováno v:
Scientific Reports
Vascular endothelial cells present luminal chemokines that arrest rolling leukocytes by activating integrins. It appears that several chemokines must form higher-order oligomers to elicit proper in vivo effects, as mutants restricted to forming dimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12c68b71afb2c636dc0d025acfece337
https://pubmed.ncbi.nlm.nih.gov/25791723
https://pubmed.ncbi.nlm.nih.gov/25791723
Autor:
Jan E. Brinchmann, Axel M. Küchler, Amilton M. Fernandes, Tommy A. Karlsen, Sarah R. Herlofsen, Yngvar Fløisand
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 5, p e62994 (2013)
PLoS ONE, Vol 8, Iss 5, p e62994 (2013)
Lesions of hyaline cartilage do not heal spontaneously, and represent a therapeutic challenge. In vitro engineering of articular cartilage using cells and biomaterials may prove to be the best solution. Patients with osteoarthritis (OA) may require t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbaf124c658a6ecee434ec3579714dad
http://europepmc.org/articles/PMC3650033
http://europepmc.org/articles/PMC3650033
Autor:
Kjetil Taskén, Junbai Wang, Johanna Bodin, Eirik Sundlisæter, Monika Kasprzycka, Reidunn J Edelmann, Mari Johanna Brox, Olav Sundnes, Axel M. Küchler, Sigrid S. Skånland, Morten H. Vatn, Tamara Loos, Johanna Hol, Jon Sponheim, Jürgen Pollheimer, Guttorm Haraldsen
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 33(2)
Objective— Interleukin (IL)-33 is a nuclear protein that is released from stressed or damaged cells to act as an alarmin. We investigated the effects of IL-33 on endothelial cells, using the prototype IL-1 family member, IL-1β, as a reference. Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f3fed1544abc8e068c2b9e896e822c
https://pubmed.ncbi.nlm.nih.gov/23162017
https://pubmed.ncbi.nlm.nih.gov/23162017