Výsledky vyhledávání - "Axel Leingärtner"

Akademický článek

Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

Autor: Andreas Zembrzycki, Adam M Stocker, Axel Leingärtner, Setsuko Sahara, Shen-Ju Chou, Valery Kalatsky, Scott R May, Michael P Stryker, Dennis DM O'Leary

Publikováno v: eLife, Vol 4 (2015)

In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify pri

Externí odkaz: https://doaj.org/article/9750d567fbd149fabaf6691a6293c00a

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Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

Autor: Setsuko Sahara, Andreas Zembrzycki, Shen-Ju Chou, Michael P. Stryker, Adam M. Stocker, Axel Leingärtner, Dennis D.M. O'Leary, Valery A. Kalatsky, Scott R. May

Publikováno v: eLife, Vol 4 (2015)
Zembrzycki, A, Stocker, A, Leingärtner, A, Sahara, S, Chou, S-J, Kalatsky, V, May, S, Stryker, M & O'Leary, D DM 2015, ' Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. ', eLife, vol. 4, no. 0, e11416 . https://doi.org/10.7554/eLife.11416
eLife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5dd66348b91438803a7e9d02e0bec6
https://elifesciences.org/articles/11416

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Cortical area size dictates performance at modality-specific behaviors

Autor: Shen-Ju Chou, Fred H. Gage, Sandrine Thuret, Todd T. Kroll, Axel Leingärtner, J. Leigh Leasure, Dennis D.M. O'Leary

Publikováno v: Proceedings of the National Academy of Sciences. 104:4153-4158

The mammalian neocortex is organized into unique areas that serve functions such as sensory perception and modality-specific behaviors. The sizes of primary cortical areas vary across species, and also within a species, raising the question of whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804bd872665a3ba6dac2e422913a75d0
https://doi.org/10.1073/pnas.0611723104

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Author response: Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

Autor: Dennis D.M. O'Leary, Michael P. Stryker, Setsuko Sahara, Valery A. Kalatsky, Shen-Ju Chou, Axel Leingärtner, Adam M. Stocker, Andreas Zembrzycki, Scott R. May

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::279099c97761977e4cbd92986e91679a
https://doi.org/10.7554/elife.11416.015

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Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy

Autor: William Fumey, Axel Leingärtner, Martin Trepel, Joanna Schmid, Peter Bannas, Björn Rissiek, Valentin Kunick, Alexander Lenz, Friedrich Koch-Nolte, Friedrich Haag, Gerhard Adam

Publikováno v: Journal of Visualized Experiments.

This protocol outlines the steps required to perform ex vivo validation of in vivo near-infrared fluorescence (NIRF) xenograft imaging experiments in mice using fluorophore labelled nanobodies and conventional antibodies. First we describe how to gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2de59e92aeda70a94abcea6e8022ec2
https://doi.org/10.3791/52462

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EMX2 Regulates Sizes and Positioning of the Primary Sensory and Motor Areas in Neocortex by Direct Specification of Cortical Progenitors

Autor: Dennis D.M. O'Leary, Tadashi Hamasaki, Axel Leingärtner, Thomas Ringstedt

Publikováno v: Neuron. 43:359-372

Genetic studies of neocortical area patterning are limited, because mice deficient for candidate regulatory genes die before areas emerge and have other complicating issues. To define roles for the homeodomain transcription factor EMX2, we engineered

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567e41b5e9e99af2f53c6b58de0164f8
https://doi.org/10.1016/j.neuron.2004.07.016

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Geniculocortical input drives genetic distinctions between primary and higher-order visual areas

Autor: Dennis D.M. O'Leary, Zoila Babot, Michèle Studer, Shen Ju Chou, Axel Leingärtner, Yasushi Nakagawa

Publikováno v: Science
Science, American Association for the Advancement of Science, 2013, 340 (6137), pp.1239-42. ⟨10.1126/science.1232806⟩

Dividing the Brain The cerebral cortex of the brain is organized into primary cortical areas, which receive direct inputs from the thalamus, and higher-order cortical areas, which in turn receive inputs from one or more primary cortical areas. Chou e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52701886b4bed4900b10c1aff8c0e191
https://hal.archives-ouvertes.fr/hal-00843181

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Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation

Autor: Eero Castrén, L Tesarollo, Carl-Philipp Heisenberg, LF Parada, L Tessarollo, Dan Lindholm, Roland Kolbeck, Pantelis Tsoulfas, Axel Leingärtner, M. da Penha Berzaghi, Hans Thoenen

Publikováno v: Journal of Cell Biology. 122:443-450

Thyroid hormones play an important role in brain development, but the mechanism(s) by which triiodothyronine (T3) mediates neuronal differentiation is poorly understood. Here we demonstrate that T3 regulates the neurotrophic factor, neurotrophin-3 (N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68fd374d6e13e77e457f00ad691936e4
https://doi.org/10.1083/jcb.122.2.443

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Regulation of laminar and area patterning of mammalian neocortex and behavioural implications

Autor: Dennis D M, O'Leary, Shen-Ju, Chou, Tadashi, Hamasaki, Setsuko, Sahara, Akihide, Takeuchi, Sandrine, Thuret, Axel, Leingärtner

Publikováno v: Novartis Foundation symposium. 288

We will focus on describing our recent studies on the laminar and area patterning of the mammalian neocortex. We describe a novel IgCAM, MDGA1, that is a unique laminar and area specific marker, and functional studies showing its influence on radial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dda7c427551dbba0a99bf659cf28055f
https://pubmed.ncbi.nlm.nih.gov/18494257

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COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas

Autor: Michèle Studer, Maria Armentano, Giulio Srubek Tomassy, Shen-Ju Chou, Axel Leingärtner, Dennis D.M. O'Leary

Publikováno v: Nature neuroscience. 10(10)

We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is obser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323f4a5d7f1642c9050b60659c2674b8
https://pubmed.ncbi.nlm.nih.gov/17828260

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