Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

Autor: Andreas Zembrzycki, Adam M Stocker, Axel Leingärtner, Setsuko Sahara, Shen-Ju Chou, Valery Kalatsky, Scott R May, Michael P Stryker, Dennis DM O'Leary

Publikováno v: eLife, Vol 4 (2015)

In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify pri

Externí odkaz: https://doaj.org/article/9750d567fbd149fabaf6691a6293c00a

Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

Autor: Setsuko Sahara, Andreas Zembrzycki, Shen-Ju Chou, Michael P. Stryker, Adam M. Stocker, Axel Leingärtner, Dennis D.M. O'Leary, Valery A. Kalatsky, Scott R. May

Publikováno v: eLife, Vol 4 (2015)
Zembrzycki, A, Stocker, A, Leingärtner, A, Sahara, S, Chou, S-J, Kalatsky, V, May, S, Stryker, M & O'Leary, D DM 2015, ' Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. ', eLife, vol. 4, no. 0, e11416 . https://doi.org/10.7554/eLife.11416
eLife

In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5dd66348b91438803a7e9d02e0bec6
https://elifesciences.org/articles/11416

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy

Autor: William Fumey, Axel Leingärtner, Martin Trepel, Joanna Schmid, Peter Bannas, Björn Rissiek, Valentin Kunick, Alexander Lenz, Friedrich Koch-Nolte, Friedrich Haag, Gerhard Adam

Publikováno v: Journal of Visualized Experiments.

This protocol outlines the steps required to perform ex vivo validation of in vivo near-infrared fluorescence (NIRF) xenograft imaging experiments in mice using fluorophore labelled nanobodies and conventional antibodies. First we describe how to gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2de59e92aeda70a94abcea6e8022ec2
https://doi.org/10.3791/52462

Geniculocortical input drives genetic distinctions between primary and higher-order visual areas

Autor: Dennis D.M. O'Leary, Zoila Babot, Michèle Studer, Shen Ju Chou, Axel Leingärtner, Yasushi Nakagawa

Publikováno v: Science
Science, American Association for the Advancement of Science, 2013, 340 (6137), pp.1239-42. ⟨10.1126/science.1232806⟩

Dividing the Brain The cerebral cortex of the brain is organized into primary cortical areas, which receive direct inputs from the thalamus, and higher-order cortical areas, which in turn receive inputs from one or more primary cortical areas. Chou e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52701886b4bed4900b10c1aff8c0e191
https://hal.archives-ouvertes.fr/hal-00843181

Regulation of laminar and area patterning of mammalian neocortex and behavioural implications

Autor: Dennis D M, O'Leary, Shen-Ju, Chou, Tadashi, Hamasaki, Setsuko, Sahara, Akihide, Takeuchi, Sandrine, Thuret, Axel, Leingärtner

Publikováno v: Novartis Foundation symposium. 288

We will focus on describing our recent studies on the laminar and area patterning of the mammalian neocortex. We describe a novel IgCAM, MDGA1, that is a unique laminar and area specific marker, and functional studies showing its influence on radial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dda7c427551dbba0a99bf659cf28055f
https://pubmed.ncbi.nlm.nih.gov/18494257