Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Axel Kirchhofer"'
Autor:
Karl-Peter Hopfner, Gregor Witte, Manuela Moldt, Axel Kirchhofer, Kerstin Monika Schuhmann, Karl-Klaus Conzelmann, Carina Motz
Publikováno v:
Science. 339:690-693
Parainfluenza 5 and MDA5 Our immune system and the viruses that infect us are in a constant arms race, with one side always trying to outwit the other. One example is the inhibition of host protein MDA5, a member of the retinoic acid–inducible gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18af68b079110e29ff11995243b73ea
https://doi.org/10.1126/science.1230949
https://doi.org/10.1126/science.1230949
Autor:
Katrin Schmidthals, Ulrich Rothbauer, Axel Kirchhofer, Jonas Helma, Corella S. Casas-Delucchi, Karl-Peter Hopfner, Sheng Cui, Serge Muyldermans, Mireille Pellis, Carina Frauer, Heinrich Leonhardt, Annette Karcher, M. Cristina Cardoso
Publikováno v:
Nature Structural & Molecular Biology. 17:133-138
Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. Here we report the selection of camelid-derived single-domain antibodies (nanobodies) that modulate the conformation and spectral prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45f86811ce798e541f1d66210bef723
https://doi.org/10.1038/nsmb.1727
https://doi.org/10.1038/nsmb.1727
Autor:
Karl-Peter Hopfner, Axel Kirchhofer, Michaela U. Gack, Sua Myong, Taekjip Ha, Jae U. Jung, Peter V. Cornish, Sheng Cui
Publikováno v:
Science. 323:1070-1074
Retinoic acid inducible–gene I (RIG-I) is a cytosolic multidomain protein that detects viral RNA and elicits an antiviral immune response. Two N-terminal caspase activation and recruitment domains (CARDs) transmit the signal, and the regulatory dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4999b1dea6a0ea5bda6a7a043ded3c9e
https://doi.org/10.1126/science.1168352
https://doi.org/10.1126/science.1168352
Autor:
Taekjip Ha, Young C. Shin, Karl-Peter Hopfner, Axel Kirchhofer, Jae U. Jung, Michaela U. Gack, Kyung-Soo Inn, Chengyu Liang, Sheng Cui, Sua Myong
Publikováno v:
Proceedings of the National Academy of Sciences. 105:16743-16748
The caspase recruitment domain (CARD) of intracellular adaptors and sensors plays a critical role in the assembly of signaling complexes involved in innate host defense against pathogens and in the regulation of inflammatory responses. The cytosolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c79302d0daa56060627e9ba15311783
https://doi.org/10.1073/pnas.0804947105
https://doi.org/10.1073/pnas.0804947105
Publikováno v:
RNA Helicases ISBN: 9781847559142
RIG-I-like proteins represent one of the smallest SF2 families. In humans, the RIG-I-like family encompasses RIG-I, MDA5 and LGP2 and Dicer, which are involved in RNA-related processes, as well as the DNA-repair protein FancM. In fungi, there appears
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b49cd035125a42954b2586801485fb23
https://doi.org/10.1039/9781849732215-00121
https://doi.org/10.1039/9781849732215-00121
Autor:
Sheng Cui, Johannes C. Hellmuth, Diana A. Pippig, Simon Rothenfusser, Axel Kirchhofer, Andreas Schmidt, Alfred Lammens, Katja Lammens, Karl-Peter Hopfner
Publikováno v:
Nucleic Acids Research
Nucleic acids research 37(6), 2014-2025 (2009). doi:10.1093/nar/gkp059
Nucleic acids research 37(6), 2014-2025 (2009). doi:10.1093/nar/gkp059
Nucleic acids symposium series 37(6), 2014 - 2025 (2009). doi:10.1093/nar/gkp059
Published by Oxford Univ. Press8619, Oxford
Published by Oxford Univ. Press8619, Oxford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da5c4ab2806deeeb341ae8c73be5081
Autor:
Anne Krug, Axel Kirchhofer, Sheng Cui, Karl-Peter Hopfner, Takashi Fujita, Krzysztof Brzózka, Alfred Lammens, Karl-Klaus Conzelmann, Katharina Eisenächer, Katja Lammens
Publikováno v:
Molecular cell. 29(2)
The ATPase RIG-I senses viral RNAs that contain 5'-triphosphates in the cytoplasm. It initiates a signaling cascade that activates innate immune response by interferon and cytokine production, providing essential antiviral protection for the host. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91df94765d2e637e12da4e7777cdd220
https://pubmed.ncbi.nlm.nih.gov/18243112
https://pubmed.ncbi.nlm.nih.gov/18243112