Výsledky vyhledávání - "Axel Karl Walch"

Akademický článek

Succinate mediates inflammation-induced adrenocortical dysfunction

Publikováno v: eLife, Vol 12 (2023)

The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, severe infla

Externí odkaz: https://doaj.org/article/d76bdfc84c5744ebb32985d191ed6174

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Akademický článek

Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma

Autor: Julian P. Maier, Vidhya M. Ravi, Jan Kueckelhaus, Simon P. Behringer, Niklas Garrelfs, Paulina Will, Na Sun, Jasmin von Ehr, Jonathan M. Goeldner, Dietmar Pfeifer, Marie Follo, Luciana Hannibal, Axel Karl Walch, Ulrich G. Hofmann, Jürgen Beck, Dieter Henrik Heiland, Oliver Schnell, Kevin Joseph

Publikováno v: Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)

Abstract Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of an immediate resistance dur

Externí odkaz: https://doaj.org/article/b89ed836d7234b6e8298f323cfead154

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Akademický článek

Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate

Autor: Diana C Rodriguez Camargo, Kyle J Korshavn, Alexander Jussupow, Kolio Raltchev, David Goricanec, Markus Fleisch, Riddhiman Sarkar, Kai Xue, Michaela Aichler, Gabriele Mettenleiter, Axel Karl Walch, Carlo Camilloni, Franz Hagn, Bernd Reif, Ayyalusamy Ramamoorthy

Publikováno v: eLife, Vol 6 (2017)

Membrane-assisted amyloid formation is implicated in human diseases, and many of the aggregating species accelerate amyloid formation and induce cell death. While structures of membrane-associated intermediates would provide tremendous insights into

Externí odkaz: https://doaj.org/article/83e9a3672fef478bbca4e26152d644a1

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Akademický článek

Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice.

Autor: Anke Wittmann, Marcus O W Grimm, Harry Scherthan, Marion Horsch, Johannes Beckers, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis, Steven J Ford, Neal C Burton, Daniel Razansky, Dietrich Trümbach, Michaela Aichler, Axel Karl Walch, Julia Calzada-Wack, Frauke Neff, Wolfgang Wurst, Tobias Hartmann, Thomas Floss

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164298 (2016)

Sphingolipids and the derived gangliosides have critical functions in spermatogenesis, thus mutations in genes involved in sphingolipid biogenesis are often associated with male infertility. We have generated a transgenic mouse line carrying an inser

Externí odkaz: https://doaj.org/article/af78c7a2bc0546e29b95d8ed556a9ed4

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Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome

Autor: Dorn, J., Yassouridis, A., Axel Karl Walch, Diamandis, E. P., Schmitt, M., Kiechle, M., Wang, P., Drecoll, E., Schmalfeldt, B., Loessner, D., Kotzsch, M., Magdolen, V.

Publikováno v: Scopus-Elsevier
Am. J. Cancer Res. 6, 61-70 (2016)

Members of the human kallikrein-related peptidase (KLK) family, including KLK5, have been reported to play an important role in ovarian cancer progression. In the present study, we assessed KLK5 protein expression in ovarian cancer tissues by immunoh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eaf908d9ceb84a975940b24e22eaa92d
https://europepmc.org/articles/PMC4759397/

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MALDI mass spectrometry imaging of formalin-fixed paraffin-embedded tissues in clinical research

Autor: Gorzolka, K., Axel Karl Walch

Publikováno v: DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname
Scopus-Elsevier

The molecular investigation of archived formalin-fixed, paraffin-embedded (FFPE) tissue samples provides the chance to obtain molecular patterns as indicatives for treatment and clinical end points. MALDI mass spectrometry imaging is capable of local

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::dce09dd933d491d67e23b5481a09703c
http://hdl.handle.net/10201/76944

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