Výsledky vyhledávání - "Axel K. Hansen"

Akademický článek

Probiotic treatment with viable α‐galactosylceramide‐producing Bacteroides fragilis reduces diabetes incidence in female nonobese diabetic mice

Autor: Camilla H. F. Hansen, Danica Jozipovic, Line F. Zachariassen, Dennis S. Nielsen, Axel K. Hansen, Karsten Buschard

Publikováno v: Journal of Diabetes, Vol 16, Iss 8, Pp n/a-n/a (2024)

Abstract Background We aimed to investigate whether alpha‐galactosylceramide (α‐GalCer)‐producing Bacteroides fragilis could induce natural killer T (NKT) cells in nonobese diabetic (NOD) mice and reduce their diabetes incidence. Methods Five�

Externí odkaz: https://doaj.org/article/4cec84cbefda40dd8af278745cb6220a

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Akademický článek

The intestinal permeability marker FITC-dextran 4kDa should be dosed according to lean body mass in obese mice

Autor: Louise M. Voetmann, Bidda Rolin, Rikke K. Kirk, Charles Pyke, Axel K. Hansen

Publikováno v: Nutrition & Diabetes, Vol 13, Iss 1, Pp 1-5 (2023)

Abstract Aims To investigate the influence of the dose in the FITC-Dextran 4kDa (FD-4) permeability test in an obese mouse model, we tested the bodyweight dose regimen and a lean body mass-based dose regimen in high fat diet (HFD) mice and low fat di

Externí odkaz: https://doaj.org/article/8c16f181714e492db1c3c4c253eb04ca

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Akademický článek

Delayed Gut Colonization Shapes Future Allergic Responses in a Murine Model of Atopic Dermatitis

Autor: Amalie W. Arildsen, Line F. Zachariassen, Lukasz Krych, Axel K. Hansen, Camilla H. F. Hansen

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Epidemiological studies have long reported that perturbations of the childhood microbiome increase the risk of developing allergies, but a causal relationship with atopic dermatitis remains unclear. Here we colonized germ-free mice at birth or at one

Externí odkaz: https://doaj.org/article/59e67aee7d5e46bf8c4b00cc3bf6e022

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Akademický článek

A Humanized Diet Profile May Facilitate Colonization and Immune Stimulation in Human Microbiota-Colonized Mice

Autor: Isabel Moreno-Indias, Randi Lundberg, Lukasz Krych, Stine Broeng Metzdorff, Witold Kot, Dorte Bratbo Sørensen, Dennis Sandris Nielsen, Camilla Hartmann Friis Hansen, Axel K. Hansen

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

BackgroundIn spite of the importance of the use of gnotobiotic mice for human fecal transfer, colonization efficiency and immune stimulation after human microbiota inoculation in mice are poorly studied compared to mouse microbiota inoculation. We te

Externí odkaz: https://doaj.org/article/fa26529035644d4a81229766cb40d3cf

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Akademický článek

Treatment with a Monoclonal Anti-IL-12p40 Antibody Induces Substantial Gut Microbiota Changes in an Experimental Colitis Model

Autor: Josué Castro-Mejía, Maja Jakesevic, Łukasz Krych, Dennis S. Nielsen, Lars H. Hansen, Bodil C. Sondergaard, Peter H. Kvist, Axel K. Hansen, Thomas L. Holm

Publikováno v: Gastroenterology Research and Practice, Vol 2016 (2016)

Background and Aim. Crohn’s disease is associated with gut microbiota (GM) dysbiosis. Treatment with the anti-IL-12p40 monoclonal antibody (12p40-mAb) has therapeutic effect in Crohn’s disease patients. This study addresses whether a 12p40-mAb tr

Externí odkaz: https://doaj.org/article/fb6f359e86ac4ef189daf717302497dc

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In vitro cell cultures of Brunner’s glands from male mouse to study GLP-1 receptor function

Autor: Louise M. Voetmann, Christina R. Underwood, Bidda Rolin, Axel K. Hansen, Rikke K. Kirk, Charles Pyke, Lotte B. Knudsen, Klaus S. Frederiksen

Publikováno v: Voetmann, L M, Underwood, C R, Rolin, B, Hansen, A K, Kirk, R K, Pyke, C, Knudsen, L B & Frederiksen, K S 2022, ' In vitro cell cultures of Brunner's glands from male mouse to study GLP-1 receptor function ', American journal of physiology. Cell physiology, vol. 322, no. 6, pp. C1260-C1269 . https://doi.org/10.1152/ajpcell.00345.2021

Exocrine glands in the submucosa of the proximal duodenum secrete alkaline fluid containing mucus to protect the intestinal mucosa from acidic stomach contents. These glands, known as Brunner’s glands, express high glucagon-like peptide 1 receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56cc99bef32b6101469030ddfc5a830
https://doi.org/10.1152/ajpcell.00345.2021

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Yogurt Benefits Bone Mineralization in Ovariectomized Rats with Concomitant Modulation of the Gut Microbiome

Autor: Weiwei He, Zhuqing Xie, Nina Kølln Wittig, Line F. Zachariassen, Amanda Andersen, Henrik J. Andersen, Henrik Birkedal, Dennis S. Nielsen, Axel K. Hansen, Hanne Christine Bertram

Publikováno v: He, W, Xie, Z, Wittig, N K, Zachariassen, L F, Andersen, A, Andersen, H J, Birkedal, H, Nielsen, D S, Kornerup Hansen, A & Bertram, H C 2022, ' Yogurt Benefits Bone Mineralization in Ovariectomized Rats with Concomitant Modulation of the Gut Microbiome ', Molecular Nutrition & Food Research, vol. 66, no. 20, 2200174 . https://doi.org/10.1002/mnfr.202200174
He, W, Xie, Z, Wittig, N K, Zachariassen, L F, Andersen, A, Andersen, H J, Birkedal, H, Nielsen, D S, Hansen, A K & Bertram, H C 2022, ' Yogurt Benefits Bone Mineralization in Ovariectomized Rats with Concomitant Modulation of the Gut Microbiome ', Molecular Nutrition and Food Research, vol. 66, no. 20, 2200174 . https://doi.org/10.1002/mnfr.202200174

SCOPE: Evidence supports that gut-modulating foods potentially can supress bone loss in postmenopausal women. This study aimed to investigate the effect of milk calcium-enriched milk, yogurt, and yogurt-inulin combination on the gut-bone association.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c086552b3d87aaea60e4a5faa921af11
https://pure.au.dk/portal/da/publications/yogurt-benefits-bone-mineralization-in-ovariectomized-rats-with-concomitant-modulation-of-the-gut-microbiome(d2459c41-4bc5-4a1e-87d9-d7e3bffae390).html

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Dual nuclear magnetic resonance for probing intrinsic bone structure and a potential gut–bone axis in ovariectomized rats

Autor: Weiwei He, Louise M. A. Jakobsen, Line F. Zachariassen, Axel K. Hansen, Henrik J. Andersen, Hanne Christine Bertram

Publikováno v: He, W, Jakobsen, L M A, Zachariassen, L F, Hansen, A K, Andersen, H J & Bertram, H C 2022, ' Dual nuclear magnetic resonance for probing intrinsic bone structure and a potential gut–bone axis in ovariectomized rats ', Magnetic Resonance in Chemistry, vol. 60, no. 7, pp. 651-658 . https://doi.org/10.1002/mrc.5244
He, W, Jakobsen, L M A, Zachariassen, L F, Hansen, A K, Andersen, H J & Bertram, H C S 2022, ' Dual nuclear magnetic resonance for probing intrinsic bone structure and a potential gut–bone axis in ovariectomized rats ', Magnetic Resonance in Chemistry, vol. 60, no. 7, pp. 651-658 . https://doi.org/10.1002/mrc.5244, https://doi.org/10.1002/mrc.5244

Currently, the existence of a gut–bone axis receives massive attention, and while sound premises and indirect proofs exist for the gut–bone axis concept, few studies have provided actual data linking the gut and bone physically. This study aimed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec2229a3940b0e7e6edfbdc74dcef5b
https://curis.ku.dk/portal/da/publications/dual-nuclear-magnetic-resonance-for-probing-intrinsic-bone-structure-and-a-potential-gutbone-axis-in-ovariectomized-rats(7941c1ea-df88-49a3-973d-e3df014cbae5).html

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Gluten-free diet reduces autoimmune diabetes mellitus in mice across multiple generations in a microbiota-independent manner

Autor: Camilla H.F. Hansen, Christian S. Larsen, Line F. Zachariassen, Caroline M.J. Mentzel, Ann Laigaard, Lukasz Krych, Dennis S. Nielsen, Alex Gobbi, Martin Haupt-Jorgensen, Karsten Buschard, Axel K. Hansen

Publikováno v: Journal of autoimmunity. 127

Experimental and clinical data suggest that a gluten-free diet attenuates the development of type 1 diabetes. A gluten-free diet changes the gut microbiota composition, and such microbial changes are expected to reduce the autoimmune responses. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76170e35677140fcfedeea5104c2437
https://pubmed.ncbi.nlm.nih.gov/35101708

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The intestinal permeability marker FITC-dextran 4kDa should be dosed according to lean body mass in obese mice

Autor: Louise M, Voetmann, Bidda, Rolin, Rikke K, Kirk, Charles, Pyke, Axel K, Hansen

Publikováno v: Nutritiondiabetes. 13(1)

To investigate the influence of the dose in the FITC-Dextran 4kDa (FD-4) permeability test in an obese mouse model, we tested the bodyweight dose regimen and a lean body mass-based dose regimen in high fat diet (HFD) mice and low fat diet (LFD) mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56d3cde539725144f20fc6715e0f3ba5
https://pubmed.ncbi.nlm.nih.gov/36604407

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