Zobrazeno 1 - 10 of 92 pro vyhledávání: '"Axel J Scheidig"'
1
Akademický článek
Interface analysis of the complex between ERK2 and PTP-SL.
Autor: Mihaela C Balasu, Laurentiu N Spiridon, Simona Miron, Constantin T Craescu, Axel J Scheidig, Andrei-Jose Petrescu, Stefan E Szedlacsek
Publikováno v: PLoS ONE, Vol 4, Iss 5, p e5432 (2009)
The activity of ERK2, an essential component of MAP-kinase pathway, is under the strict control of various effector proteins. Despite numerous efforts, no crystal structure of ERK2 complexed with such partners has been obtained so far. PTP-SL is a ma
Externí odkaz: https://doaj.org/article/f07a28e66455426a8ad5a65a6c675669
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2
Akademický článek
Reduction of Hydrogen Peroxide by Human Mitochondrial Amidoxime Reducing Component Enzymes
Autor: Sophia Rixen, Patrick M. Indorf, Christian Kubitza, Michel A. Struwe, Cathrin Klopp, Axel J. Scheidig, Thomas Kunze, Bernd Clement
Publikováno v: Molecules, Vol 28, Iss 17, p 6384 (2023)
The mitochondrial amidoxime reducing component (mARC) is a human molybdoenzyme known to catalyze the reduction of various N-oxygenated substrates. The physiological function of mARC enzymes, however, remains unknown. In this study, we examine the red
Externí odkaz: https://doaj.org/article/96401eb5c24d4951a7e7703198414bbe
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4
Akademický článek
Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17
Autor: Sebastian Krossa, Axel J. Scheidig, Joachim Grötzinger, Inken Lorenzen
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract A Disintegrin and Metalloprotease 17 (ADAM17) can cause the fast release of growth factors and inflammatory mediators from the cell surface. Its activity has to be turned on which occurs by various stimuli. The active form can be inactivated
Externí odkaz: https://doaj.org/article/8e0352618ebd453ea2b6906d705d91f7
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5
Structural and catalytic characterization of Blastochloris viridis and Pseudomonas aeruginosa homospermidine synthases supports the essential role of cation–π interaction
Autor: Axel J. Scheidig, Felix Helfrich
Publikováno v: Acta Crystallographica. Section D, Structural Biology
Acta crystallographica / Section D 77(10), 1317-1335 (2021). doi:10.1107/S2059798321008937
The homospermidine synthases from P. aeruginosa and B. viridis, as well as their single-residue variants, are compared based on crystal structures and activity assays. A high structural similarity is demonstrated, suggesting the equivalent involvemen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea603b9f85734ddbab8ffc9b32b8703
https://doi.org/10.1107/s2059798321008937
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6
Identification of New Antibodies Targeting Malignant Plasma Cells for Immunotherapy by Next-Generation Sequencing-Assisted Phage Display
Autor: Steffen, Krohn, Ammelie Svea, Boje, Carina Lynn, Gehlert, Sebastian, Lutz, Nikos, Darzentas, Henrik, Knecht, Dietrich, Herrmann, Monika, Brüggemann, Axel J, Scheidig, Katja, Weisel, Martin, Gramatzki, Matthias, Peipp, Katja, Klausz
Publikováno v: Frontiers in Immunology. 13
To identify new antibodies for the treatment of plasma cell disorders including multiple myeloma (MM), a single-chain Fragment variable (scFv) antibody library was generated by immunizing mice with patient-derived malignant plasma cells. To enrich an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43287f649f4ca86b45d79b68412764ac
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7
Drug Metabolism by the Mitochondrial Amidoxime Reducing Component (mARC): Rapid Assay and Identification of New Substrates
Autor: Bernd Clement, Christian Kubitza, Thomas Kunze, Axel J. Scheidig, Patrick Indorf
Publikováno v: Journal of Medicinal Chemistry. 63:6538-6546
For the development of new drugs, the investigation of their metabolism is of central importance. In the past, the focus was mostly on the consideration of established enzymes leading to oxidations such as cytochrome P450. However, reductive metaboli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e2dc945778b1ec8642974b8aad6c69
https://doi.org/10.1021/acs.jmedchem.9b01483
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8
Crystal structure of a xylulose 5-phosphate phosphoketolase. Insights into the substrate specificity for xylulose 5-phosphate
Autor: Axel J. Scheidig, Stefan E. Szedlacsek, Dragos Horvath
Publikováno v: Journal of Structural Biology
Journal of Structural Biology, Elsevier, 2019, 207 (1), pp.85-102. ⟨10.1016/j.jsb.2019.04.017⟩
Phosphoketolases (PK) are TPP-dependent enzymes which play essential roles in carbohydrate metabolism of numerous bacteria. Depending on the substrate specificity PKs can be subdivided into xylulose 5-phosphate (X5P) specific PKs (XPKs) and PKs which
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf9eb6a51403bd1eb2f5a047362cf34
https://doi.org/10.1016/j.jsb.2019.04.017
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10
WHIRLY1 of barley and maize share a PRAPP motif conferring nucleoid compaction
Autor: Karin Krupinska, Svenja Oetke, Axel J. Scheidig
WHIRLY1 in barley was shown to be a major architect of plastid nucleoids. Its accumulation in cells of E. coli coincided with an induction of nucleoid compaction and growth retardation. While WHIRLY1 of maize had similar effects on E. coli cells, WHI
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca0fe94905b83c21256ca878bfd784a
https://doi.org/10.1101/2020.10.19.344945
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