Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Axel Imhof"'
Autor:
Monika Ayten, Nundehui Díaz-Lezama, Hanaa Ghanawi, Felia C. Haffelder, Jacqueline Kajtna, Tobias Straub, Marco Borso, Axel Imhof, Stefanie M. Hauck, Susanne F. Koch
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 101994- (2024)
Objective: Retinitis pigmentosa (RP) is a hereditary retinal disease characterized by progressive photoreceptor degeneration, leading to vision loss. The best hope for a cure for RP lies in gene therapy. However, given that RP patients are most often
Externí odkaz:
https://doaj.org/article/113cfa47f96149168003a0ce8ce6058a
Autor:
Rupam Choudhury, Anuroop Venkateswaran Venkatasubramani, Jie Hua, Marco Borsò, Celeste Franconi, Sarah Kinkley, Ignasi Forné, Axel Imhof
Publikováno v:
eLife, Vol 13 (2024)
Eukaryotic chromatin is organized into functional domains, that are characterized by distinct proteomic compositions and specific nuclear positions. In contrast to cellular organelles surrounded by lipid membranes, the composition of distinct chromat
Externí odkaz:
https://doaj.org/article/4a0612e4d964465e801499bc97133252
Autor:
Verena Kohler, Andreas Kohler, Lisa Larsson Berglund, Xinxin Hao, Sarah Gersing, Axel Imhof, Thomas Nyström, Johanna L. Höög, Martin Ott, Claes Andréasson, Sabrina Büttner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The resilience of cellular proteostasis declines with age, which drives protein aggregation and compromises viability. The nucleus has emerged as a key quality control compartment that handles misfolded proteins produced by the cytosolic pro
Externí odkaz:
https://doaj.org/article/5dbf4037911449959b5703bfa8fbcbd3
Publikováno v:
Cancers, Vol 16, Iss 9, p 1639 (2024)
Background: Loss of the p53-inducible LINC01021 in p53-proficient CRC cell lines results in increased sensitivity to DNA-damaging chemotherapeutics. Here, we comprehensively analyze how LINC01021 affects the p53-induced transcriptional program. Metho
Externí odkaz:
https://doaj.org/article/fbfa4a8added49e8a73d3050ae513aa5
Autor:
Pedro Weickert, Hao-Yi Li, Maximilian J. Götz, Sophie Dürauer, Denitsa Yaneva, Shubo Zhao, Jacqueline Cordes, Aleida C. Acampora, Ignasi Forne, Axel Imhof, Julian Stingele
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract DNA-protein crosslinks (DPCs) are pervasive DNA lesions that are induced by reactive metabolites and various chemotherapeutic agents. Here, we develop a technique for the Purification of x-linked Proteins (PxP), which allows identification a
Externí odkaz:
https://doaj.org/article/dc7e3a77ff704d98b30b8ecc3d84505f
Autor:
Stefanie M. Herbel, Lambert Moyon, Marvin Christ, Eslam M. Elsayed, Brian E. Caffrey, Silke Malmsheimer, Iwan Grin, Kerstin Hoffmann, Kristin Surmann, Sascha Blankenburg, Anna Lena Jung, Christina E. Herkt, Marco Borsò, Beyza Bozdag, Axel Imhof, Anke Becker, Samuel Wagner, Gert Bange, Uwe Völker, Wilhelm Bertrams, Annalisa Marsico, Bernd Schmeck
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 2042-2058 (2022)
Legionella pneumophila (L.p.) is a bacterial pathogen which is a common causative agent of pneumonia. In humans, it infects alveolar macrophages and transfers hundreds of virulence factors that interfere with cellular signalling pathways and the tran
Externí odkaz:
https://doaj.org/article/3cfbe5db3b0f4145a005db5fed54388b
Autor:
Sabine Bachmaier, Giacomo Giacomelli, Estefanía Calvo-Alvarez, Larissa Rezende Vieira, Jan Van Den Abbeele, Aris Aristodemou, Esben Lorentzen, Matt K. Gould, Ana Brennand, Jean-William Dupuy, Ignasi Forné, Axel Imhof, Marc Bramkamp, Didier Salmon, Brice Rotureau, Michael Boshart
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Trypanosomes can sense signal molecules and coordinate their movement in response to such signals, a phenomenon termed social motility (SoMo). Here, Bachmaier et al show that cyclic AMP response protein 3 (CARP3) localization to the flagellar tip and
Externí odkaz:
https://doaj.org/article/78b976fc355d4e02a4db5be6fb77b12f
Autor:
Annika Müller-Eigner, Adrián Sanz-Moreno, Irene de-Diego, Anuroop Venkateswaran Venkatasubramani, Martina Langhammer, Raffaele Gerlini, Birgit Rathkolb, Antonio Aguilar-Pimentel, Tanja Klein-Rodewald, Julia Calzada-Wack, Lore Becker, Sergio Palma-Vera, Benedikt Gille, Ignasi Forne, Axel Imhof, Chen Meng, Christina Ludwig, Franziska Koch, John T. Heiker, Angela Kuhla, Vanessa Caton, Julia Brenmoehl, Henry Reyer, Jennifer Schoen, Helmut Fuchs, Valerie Gailus-Durner, Andreas Hoeflich, Martin Hrabe de Angelis, Shahaf Peleg
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
This study further characterizes the non-inbred Titan (also known as DU6) mouse line, which could be a useful model for obesity research.
Externí odkaz:
https://doaj.org/article/2312dbd92c5e4feba3bf2ae10fa71dba
Autor:
Alexander M. Bernhardt, Steffen Tiedt, Daniel Teupser, Martin Dichgans, Bernhard Meyer, Jens Gempt, Peer-Hendrik Kuhn, Mikael Simons, Carla Palleis, Endy Weidinger, Georg Nübling, Lesca Holdt, Lisa Hönikl, Christiane Gasperi, Pieter Giesbertz, Stephan A. Müller, Stephan Breimann, Stefan F. Lichtenthaler, Bernhard Kuster, Matthias Mann, Axel Imhof, Teresa Barth, Stefanie M. Hauck, Henrik Zetterberg, Markus Otto, Wilko Weichert, Bernhard Hemmer, Johannes Levin
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104456- (2023)
Summary: A major evolution from purely clinical diagnoses to biomarker supported clinical diagnosing has been occurring over the past years in neurology. High-throughput methods, such as next-generation sequencing and mass spectrometry-based proteomi
Externí odkaz:
https://doaj.org/article/ca4764cc70fd42139d3232a5510941b4
Autor:
Sophia Groh, Anna Viktoria Milton, Lisa Katherina Marinelli, Cara V. Sickinger, Angela Russo, Heike Bollig, Gustavo Pereira de Almeida, Andreas Schmidt, Ignasi Forné, Axel Imhof, Gunnar Schotta
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Endogenous retroviruses (ERVs) compose a significant portion of mammalian genomes; however, how ERVs are regulated is not well known. Here the authors performed a genome-wide sgRNA screen to identify Morc3 as a mediator of ERV silencing. They show Mo
Externí odkaz:
https://doaj.org/article/7babdca1f6d949e89f3a1f776c0144b2