Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Axel Facius"'
1
Akademický článek
Population pharmacokinetics, enzyme occupancy, and pharmacodynamic modeling of soticlestat in patients with developmental and epileptic encephalopathies
Autor: Wei Yin, Axel Facius, Mahnaz Asgharnejad, Gëzim Lahu, Majid Vakilynejad
Publikováno v: Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract Soticlestat (TAK‐935) is a first‐in‐class, selective inhibitor of cholesterol 24‐hydroxylase (CH24H) under phase III development for the treatment of the developmental and epileptic encephalopathies (DEEs), Dravet syndrome (DS), and
Externí odkaz: https://doaj.org/article/c7dd036bd4d44372b241f37bb1053a8c
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2
Akademický článek
Population pharmacokinetics, enzyme occupancy, and 24S‐hydroxycholesterol modeling of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, in healthy adults
Autor: Wei Yin, Axel Facius, Thomas Wagner, Max Tsai, Mahnaz Asgharnejad, Gëzim Lahu, Majid Vakilynejad
Publikováno v: Clinical and Translational Science, Vol 16, Iss 7, Pp 1149-1162 (2023)
Abstract Soticlestat is a first‐in‐class, selective inhibitor of cholesterol 24‐hydroxylase (CH24H), which catabolizes cholesterol to 24S‐hydroxycholesterol (24HC) in the brain, in phase III development for Dravet syndrome and Lennox–Gastau
Externí odkaz: https://doaj.org/article/d8161f844dbe4084876acfaf7017a01e
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3
Akademický článek
What Can Be Learned From Crowdsourced Population Asparagus Urinary Odor Kinetics?
Autor: Axel Facius, Linda A. Atkinson, Kelly Hanna, Mai Chi Coombes, Gezim Lahu, John A. Wagner
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 407-414 (2019)
Asparagus consumption is associated with the production of malodorous urine. Interindividual variability was previously characterized by an American Society for Clinical Pharmacology and Therapeutics crowdsourced study. To further characterize urinar
Externí odkaz: https://doaj.org/article/779304c70c794a9db16e09457ab34e18
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6
A Population Pharmacokinetic Model of Vonoprazan: Evaluating the Effects of Race, Disease Status, and Other Covariates on Exposure
Autor: Carmelo Scarpignato, Eckhard Leifke, Neila Smith, Darcy J. Mulford, Gezim Lahu, Axel Facius, Colin W. Howden
Publikováno v: The Journal of Clinical Pharmacology. 62:801-811
Vonoprazan, a potassium-competitive acid blocker, is under investigation in the United States and Europe for the treatment of erosive esophagitis and Helicobacter pylori infection. Population pharmacokinetic (popPK) analysis allows the identification
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed97e82d2dfc3694c699661d7d07a90
https://doi.org/10.1002/jcph.2019
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8
What Can Be Learned From Crowdsourced Population Asparagus Urinary Odor Kinetics?
Autor: Mai Chi Coombes, Axel Facius, John A. Wagner, Linda A. Atkinson, Kelly Hanna, Gezim Lahu
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 407-414 (2019)
CPT: Pharmacometrics & Systems Pharmacology
Asparagus consumption is associated with the production of malodorous urine. Interindividual variability was previously characterized by an American Society for Clinical Pharmacology and Therapeutics crowdsourced study. To further characterize urinar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c49b0c3f69bdce3f4dafe238d5672f1
https://doi.org/10.1002/psp4.12401
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10
Use of a 4-week up-titration regimen of roflumilast in patients with severe COPD
Autor: Axel Facius, Henrik Watz, Jonas Román, Stephen I. Rennard, Nitin Bagul, Klaus F. Rabe, Peter M.A. Calverley, Vijay Kt Alagappan
Publikováno v: International Journal of Chronic Obstructive Pulmonary Disease
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Henrik Watz,1 Nitin Bagul,2 Klaus F Rabe,3,4 Stephen Rennard,5,6 Vijay KT Alagappan,7 Jonas Román,8 Axel Facius,9 Peter MA Calverley10 1Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200633d526b18aebc27d4cf34ee60a5b
http://europepmc.org/articles/PMC5846760
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