Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Axel F. Brilot"'
Autor:
Eliza S. Nieweglowska, Axel F. Brilot, Melissa Méndez-Moran, Claire Kokontis, Minkyung Baek, Junrui Li, Yifan Cheng, David Baker, Joseph Bondy-Denomy, David A. Agard
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
To protect from host attack, numerous jumbo bacteriophages establish a micron-scale, protein-based structure to enclose their replicating DNA. Using cryoEM, the authors show that the 2D crystal enclosing this so-called phage nucleus is an assembly of
Externí odkaz:
https://doaj.org/article/f7a9df2988ef437aa0a60e5c599bd823
CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation
Autor:
Axel F Brilot, Andrew S Lyon, Alex Zelter, Shruthi Viswanath, Alison Maxwell, Michael J MacCoss, Eric G Muller, Andrej Sali, Trisha N Davis, David A Agard
Publikováno v:
eLife, Vol 10 (2021)
Microtubule (MT) nucleation is regulated by the γ-tubulin ring complex (γTuRC), conserved from yeast to humans. In Saccharomyces cerevisiae, γTuRC is composed of seven identical γ-tubulin small complex (γTuSC) sub-assemblies, which associate hel
Externí odkaz:
https://doaj.org/article/d01c66d5a03743a7bf70f392cb7c8a89
Autor:
Soumya G, Remesh, Gregory E, Merz, Axel F, Brilot, Un Seng, Chio, Alexandrea N, Rizo, Thomas H, Pospiech, Irene, Lui, Mathew T, Laurie, Jeff, Glasgow, Chau Q, Le, Yun, Zhang, Devan, Diwanji, Evelyn, Hernandez, Jocelyne, Lopez, Komal Ishwar, Pawar, Sergei, Pourmal, Amber M, Smith, Fengbo, Zhou, Joseph, DeRisi, Tanja, Kortemme, Oren S, Rosenberg, Anum, Glasgow, Kevin K, Leung, James A, Wells, Kliment A, Verba
Publikováno v:
bioRxiv
SummaryThe SARS-CoV-2 Omicron variant, with 15 mutations in Spike receptor binding domain (Spike-RBD), renders virtually all clinical monoclonal antibodies against WT SARS-CoV-2 ineffective. We recently engineered the SARS-CoV-2 host entry receptor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1536ff3a69d8411a0c8b110ffb81d62
https://pubmed.ncbi.nlm.nih.gov/35982665
https://pubmed.ncbi.nlm.nih.gov/35982665
Autor:
Soumya G. Remesh, Gregory E. Merz, Axel F. Brilot, Un Seng Chio, Alexandrea N. Rizo, Thomas H. Pospiech, Irene Lui, Mathew T. Laurie, Jeff Glasgow, Chau Q. Le, Yun Zhang, Devan Diwanji, Evelyn Hernandez, Jocelyne Lopez, Hevatib Mehmood, Komal Ishwar Pawar, Sergei Pourmal, Amber M. Smith, Fengbo Zhou, Joseph DeRisi, Tanja Kortemme, Oren S. Rosenberg, Anum Glasgow, Kevin K. Leung, James A. Wells, Kliment A. Verba
Publikováno v:
Structure. 31:253-264.e6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::465879843c6fc9af0dc47d554433893e
https://doi.org/10.1016/j.str.2023.01.009
https://doi.org/10.1016/j.str.2023.01.009
Autor:
Anna B Loveland, Eugene Bah, Rohini Madireddy, Ying Zhang, Axel F Brilot, Nikolaus Grigorieff, Andrei A Korostelev
Publikováno v:
eLife, Vol 5 (2016)
Stringent response is a conserved bacterial stress response underlying virulence and antibiotic resistance. RelA/SpoT-homolog proteins synthesize transcriptional modulators (p)ppGpp, allowing bacteria to adapt to stress. RelA is activated during amin
Externí odkaz:
https://doaj.org/article/e2ce5e5ca22a4cc7896a95764e229e8b
Autor:
Gurunathan Laxmikanthan, Chen Xu, Axel F Brilot, David Warren, Lindsay Steele, Nicole Seah, Wenjun Tong, Nikolaus Grigorieff, Arthur Landy, Gregory D Van Duyne
Publikováno v:
eLife, Vol 5 (2016)
The molecular machinery responsible for DNA expression, recombination, and compaction has been difficult to visualize as functionally complete entities due to their combinatorial and structural complexity. We report here the structure of the intact f
Externí odkaz:
https://doaj.org/article/c2dcf8cc9a88456b8a97f71a3655d550
Autor:
Jessica K. Peters, Natalia Jura, Aye C. Thwin, Mehdi Bouhaddou, Fei Li, Jocelyne Lopez, Yang Li, Kuei-Ho Chen, Erron W. Titus, Huong T. Kratochvil, Victor L Lam, Christian B. Billesbølle, Tristan W. Owens, Raphael Trenker, Axel F. Brilot, Danielle L. Swaney, Ursula Schulze-Gahmen, Feng Wang, Gregory E. Merz, Jen Chen, Amy Diallo, Yang Zhang, Adam Frost, Soumya G. Remesh, Junrui Li, Edmond Linossi, Fengbo Zhou, Maliheh Safari, Yifan Cheng, Henry C. Nguyen, Andrea Fossati, Devan Diwanji, Evelyn Hernandez, Aashish Manglik, Nevan J. Krogan, Iris D. Young, Jianhua Zhao, Kyle E. Lopez, Alexandrea N. Rizo, Megan Lo, Thomas H. Pospiech, Gwendolyn M. Jang, Y. Li, Sergei Pourmal, Yuan Zhou, Miles Sasha Dickinson, Un Seng Chio, Kaihua Zhang, Caleigh M. Azumaya, Michael D Paul, Oren S. Rosenberg, Yanxin Liu, Tsz Kin Martin Tsui, Carlos Nowotny, Kate Kim, Kliment A. Verba, Loan Doan, Zanlin Yu, Adrian Pelin, Mariano C Tabios, Lorena Zuliani-Alvarez, Daniel R. Southworth, Melody G. Campbell, Ming Sun, Adamo Mancino, Kaitlin Schaefer, Frank R. Moss, Daniel Asarnow, Meghna Gupta, James S. Fraser, Komal Ishwar Pawar, Amber M. Smith, Robert M. Stroud, Tanja Kortemme, Cristina Puchades, Michelle Moritz, Nadia Herrera, Eric Tse, Mingliang Jin, David A. Agard
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv, vol 2, iss 05-19
Research Square
article-version (status) pre
article-version (number) 1
bioRxiv, vol 2, iss 05-19
Research Square
The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but its exact functions, and the structural basis of those functions, remain unknown. Here, we report an atomic model for full-length Nsp2 obtained by combining cryo-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8c3bdd782cfa56f525ccd0d1740780
https://pubmed.ncbi.nlm.nih.gov/34013269
https://pubmed.ncbi.nlm.nih.gov/34013269
CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation
Autor:
Andrew S. Lyon, Michael J. MacCoss, Eric G D Muller, Alex Zelter, Shruthi Viswanath, Axel F. Brilot, Trisha N. Davis, David A. Agard, Andrej Sali, Alison M Maxwell
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Microtubule (MT) nucleation is regulated by the γ-tubulin ring complex (γTuRC), conserved from yeast to humans. In Saccharomyces cerevisiae, γTuRC is composed of seven identical γ-tubulin small complex (γTuSC) sub-assemblies, which associate hel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdb76111604271b162ae2cec9ef0f6d
https://elifesciences.org/articles/65168
https://elifesciences.org/articles/65168
Autor:
Axel F. Brilot, Michael J. MacCoss, David A. Agard, Andrej Sali, Andrew S. Lyon, Trisha N. Davis, Shruthi Viswanath, Alex Zelter, Eric G D Muller, Alison M Maxwell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaa3efd620e3497d9fd2618a633ee619
https://doi.org/10.7554/elife.65168.sa2
https://doi.org/10.7554/elife.65168.sa2
Autor:
Ian B. Seiple, Arthur A Tran, Justin T Biel, Dean L. Shinabarger, Beverly Murray, David Chow, Na Zhang, Kenneth W. Borrelli, Kaijie Ji, Gydo C. P. van Zundert, Jenna Pellegrino, D. John Lee, Cindy Wolfe, Jesslyn E Park, Ruoxi Wang, Qi Li, Olivier Chesneau, Estelle Mühle, Axel F. Brilot, Hector A Chaires, Matthew P. Jacobson, James S. Fraser
Publikováno v:
Nature
Nature, 2020, 586 (7827), pp.145-150. ⟨10.1038/s41586-020-2761-3⟩
Nature, vol 586, iss 7827
Nature, Nature Publishing Group, 2020, 586 (7827), pp.145-150. ⟨10.1038/s41586-020-2761-3⟩
Nature, 2020, 586 (7827), pp.145-150. ⟨10.1038/s41586-020-2761-3⟩
Nature, vol 586, iss 7827
Nature, Nature Publishing Group, 2020, 586 (7827), pp.145-150. ⟨10.1038/s41586-020-2761-3⟩
International audience; Natural products serve as chemical blueprints for most antibiotics in clinical use. The evolutionary process by which these molecules arise is inherently accompanied by the co-evolution of resistance mechanisms that shorten th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43735642a3593a0038eaf47b71d6765a
https://hal-pasteur.archives-ouvertes.fr/pasteur-03082400
https://hal-pasteur.archives-ouvertes.fr/pasteur-03082400