Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Axel C R, Diernfellner"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010331 (2022)
Eukaryotic circadian clocks are based on self-sustaining, cell-autonomous oscillatory feedback loops that can synchronize with the environment via recurrent stimuli (zeitgebers) such as light. The components of biological clocks and their network int
Externí odkaz:
https://doaj.org/article/46d972c5a7354ebe893971fac25605c5
Casein kinase 1δ (CK1δ) is a simple monomeric enzyme involved in the regulation of a variety of functions, including signal transduction, the circadian clock, and the cell cycle. Although CK1δ is targeted by the ubiquitin ligase APC/CCdh1is not un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be3f7e8472f2fcc65fff1ac85a0583a9
https://doi.org/10.1101/2023.02.13.528286
https://doi.org/10.1101/2023.02.13.528286
Publikováno v:
FEBS lettersReferences. 596(15)
Timing by the circadian clock of Neurospora is associated with hyperphosphorylation of frequency (FRQ), which depends on anchoring casein kinase 1a (CK1a) to FRQ. It is not known how CK1a is anchored so that approximately 100 sites in FRQ can be targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f0f93ea08d64a59c649be5740249ba
https://pubmed.ncbi.nlm.nih.gov/35735764
https://pubmed.ncbi.nlm.nih.gov/35735764
Autor:
Anita Szőke, Orsolya Sárkány, Géza Schermann, Orsolya Kapuy, Axel C. R. Diernfellner, Michael Brunner, Norbert Gyöngyösi, Krisztina Káldi
The circadian clock governs rhythmic cellular functions by driving expression of a substantial fraction of the genome and thereby significantly contributes to the adaptation to changing environmental conditions. Using the circadian model organism Neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9489ff591c249a491a355062411f3fa4
https://doi.org/10.1101/2022.06.06.494928
https://doi.org/10.1101/2022.06.06.494928
Publikováno v:
Journal of Biological Rhythms. :074873042311539
The circadian clock of Neurospora crassa is based on a negative transcriptional/translational feedback loops. The frequency ( frq) gene controls the morning-specific rhythmic transcription of a sense RNA encoding FRQ, the negative element of the core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19df059b3405672e787b7a9c5036ed93
https://doi.org/10.1177/07487304231153914
https://doi.org/10.1177/07487304231153914
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-11 (2013)
Abstract The light response in Neurospora is mediated by the photoreceptor and circadian transcription factor White Collar Complex (WCC). The expression rate of the WCC target genes adapts in daylight and remains refractory to moonlight, despite the
Externí odkaz:
https://doaj.org/article/40f5b061ef2342faa4561db5e2fac23d
Autor:
Daniela Marzoll, Fidel E. Serrano, Anton Shostak, Carolin Schunke, Axel C. R. Diernfellner, Michael Brunner
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Circadian clocks rely on negative feedback loops. The core circadian inhibitors, FRQ in Neurospora and PERs in animals, are progressively hyperphosphorylated, inactivated, and degraded. CK1 is essential for these clocks. Despite our know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef16fbe729022494c1f50c735be2a079
https://doi.org/10.1073/pnas.2118286119
https://doi.org/10.1073/pnas.2118286119
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83660 (2013)
We show that firefly luciferase is a stable protein when expressed at 25 °C in Neurospora, which limits its use as transcription reporter. We created a short-lived luciferase by fusing a PEST signal to its C-terminus (LUC-PEST) and applied the LUC-P
Externí odkaz:
https://doaj.org/article/e74ed0b819264b5ba247a23c9639f497
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Checkpoint kinase 2 (CHK-2) is a key component of the DNA damage response (DDR) pathway and its activation mechanism is evolutionarily conserved. We show that PERIOD-4 (PRD-4), the CHK-2 ortholog of Neurospora crassa, is part of an addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::628c352ed7fedd99a8aa5d0d39981614
https://pubmed.ncbi.nlm.nih.gov/31413202
https://pubmed.ncbi.nlm.nih.gov/31413202
Publikováno v:
Genesdevelopment. 26(5)
Circadian rhythm is regulated through multiple transcriptional/translational feedback loops. In this study, Kim et al. identify a novel role for the O-GlcNAcylation post-translation modification in controlling clock timing. Drosophila PERIOD (dPER) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9ce202798f9feeff8cdf3cd86e41a42c
https://pubmed.ncbi.nlm.nih.gov/22327476
https://pubmed.ncbi.nlm.nih.gov/22327476