Zobrazeno 1 - 10
of 471
pro vyhledávání: '"Axel A. Brakhage"'
Autor:
Sarah Dellière, Camille Chauvin, Sarah Sze Wah Wong, Markus Gressler, Valentina Possetti, Raffaella Parente, Thierry Fontaine, Thomas Krüger, Olaf Kniemeyer, Jagadeesh Bayry, Agostinho Carvalho, Axel A. Brakhage, Antonio Inforzato, Jean-Paul Latgé, Vishukumar Aimanianda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Pentraxin 3 (PTX3), a long pentraxin and a humoral pattern recognition molecule (PRM), has been demonstrated to be protective against Aspergillus fumigatus, an airborne human fungal pathogen. We explored its mode of interaction with A. fumig
Externí odkaz:
https://doaj.org/article/b58012077bfc4de9af83513f2000d485
Autor:
Norman van Rhijn, Can Zhao, Narjes Al-Furaiji, Isabelle S. R. Storer, Clara Valero, Sara Gago, Harry Chown, Clara Baldin, Rachael-Fortune Grant, Hajer Bin Shuraym, Lia Ivanova, Olaf Kniemeyer, Thomas Krüger, Elaine Bignell, Gustavo H. Goldman, Jorge Amich, Daniela Delneri, Paul Bowyer, Axel A. Brakhage, Hubertus Haas, Michael J. Bromley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract More than 10 million people suffer from lung diseases caused by the pathogenic fungus Aspergillus fumigatus. Azole antifungals represent first-line therapeutics for most of these infections but resistance is rising, therefore the identificat
Externí odkaz:
https://doaj.org/article/b48ee6e7b3ac4ef8ac88712d8df32311
Autor:
Sebastian Schruefer, Annica Pschibul, Sarah Sze Wah Wong, Tongta Sae-Ong, Thomas Wolf, Sascha Schäuble, Gianni Panagiotou, Axel A. Brakhage, Vishukumar Aimanianda, Olaf Kniemeyer, Frank Ebel
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-25 (2023)
Abstract Background Aspergillus fumigatus is a major fungal pathogen that causes severe problems due to its increasing resistance to many therapeutic agents. Fludioxonil is a compound that triggers a lethal activation of the fungal-specific High Osmo
Externí odkaz:
https://doaj.org/article/8304e9c5c1934c3f861318b175955848
Autor:
Norman van Rhijn, Can Zhao, Narjes Al-Furaiji, Isabelle S. R. Storer, Clara Valero, Sara Gago, Harry Chown, Clara Baldin, Rachael-Fortune Grant, Hajer Bin Shuraym, Lia Ivanova, Olaf Kniemeyer, Thomas Krüger, Elaine Bignell, Gustavo H. Goldman, Jorge Amich, Daniela Delneri, Paul Bowyer, Axel A. Brakhage, Hubertus Haas, Michael J. Bromley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e844ea14cdc94abd9b868de3f1484f0e
Autor:
Mohammad H. Mirhakkak, Xiuqiang Chen, Yueqiong Ni, Thorsten Heinekamp, Tongta Sae-Ong, Lin-Lin Xu, Oliver Kurzai, Amelia E. Barber, Axel A. Brakhage, Sebastien Boutin, Sascha Schäuble, Gianni Panagiotou
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Aspergillus fumigatus, an opportunistic human pathogen, frequently infects the lungs of people with cystic fibrosis and is one of the most common causes of infectious-disease death in immunocompromised patients. Here, we construct 252 strain
Externí odkaz:
https://doaj.org/article/e8d5fb99e5474f61bb345e85e225884e
Autor:
Bernardo Ramírez-Zavala, Darina Betsova, Sonja Schwanfelder, Ines Krüger, Austin Mottola, Thomas Krüger, Olaf Kniemeyer, Axel A. Brakhage, Joachim Morschhäuser
Publikováno v:
mSphere, Vol 8, Iss 6 (2023)
ABSTRACTThe highly conserved heterotrimeric protein kinase SNF1 is important for metabolic adaptations in the pathogenic yeast Candida albicans. A key function of SNF1 is to inactivate the repressor protein Mig1 and thereby allow the expression of ge
Externí odkaz:
https://doaj.org/article/d8d62bc842d749c28592f7bd32e84e94
Autor:
Philipp Wein, Katharina Dornblut, Sebastian Herkersdorf, Thomas Krüger, Evelyn M. Molloy, Axel A. Brakhage, Dirk Hoffmeister, Christian Hertweck
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT The soft rot pathogen Janthinobacterium agaricidamnosum causes devastating damage to button mushrooms (Agaricus bisporus), one of the most cultivated and commercially relevant mushrooms. We previously discovered that this pathogen releases t
Externí odkaz:
https://doaj.org/article/a43d816f69614a7983d9c4fbbdca3ee2
Autor:
Bettina Böttcher, Dominik Driesch, Thomas Krüger, Enrico Garbe, Franziska Gerwien, Olaf Kniemeyer, Axel A. Brakhage, Slavena Vylkova
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Candida albicans biofilm maturation is accompanied by enhanced expression of amino acid acquisition genes. Three state-of-the-art omics techniques were applied to detail the importance of active amino acid uptake during biofilm development.
Externí odkaz:
https://doaj.org/article/0758b4b5e97644d392ae207bf16dedde
Autor:
Arianna Sala, Andrea Ardizzoni, Luca Spaggiari, Nikhil Vaidya, Jane van der Schaaf, Cosmeri Rizzato, Claudio Cermelli, Selene Mogavero, Thomas Krüger, Maximilian Himmel, Olaf Kniemeyer, Axel A. Brakhage, Benjamin L. King, Antonella Lupetti, Manola Comar, Francesco de Seta, Arianna Tavanti, Elisabetta Blasi, Robert T. Wheeler, Eva Pericolini
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Vulvovaginal candidiasis (VVC) affects nearly 3/4 of women during their lifetime, and its symptoms seriously reduce quality of life. Although Candida albicans is a common commensal, it is unknown if VVC results from a switch from a commensal
Externí odkaz:
https://doaj.org/article/0f04dab6756f43c9bb3b3df5ba431384
Autor:
Carsten Schwarz, Patience Eschenhagen, Henrijette Schmidt, Thordis Hohnstein, Christina Iwert, Claudia Grehn, Jobst Roehmel, Eva Steinke, Mirjam Stahl, Laura Lozza, Ekaterina Tikhonova, Elisa Rosati, Ulrik Stervbo, Nina Babel, Jochen G. Mainz, Hilmar Wisplinghoff, Frank Ebel, Lei-Jie Jia, Matthew G. Blango, Peter Hortschansky, Sascha Brunke, Bernhard Hube, Axel A. Brakhage, Olaf Kniemeyer, Alexander Scheffold, Petra Bacher
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
BACKGROUND The fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi, but the types of A. fumigatus–specific Th cells in pwCF and their cont
Externí odkaz:
https://doaj.org/article/952a35bb46204b4d99016140937e7c30