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of 5
pro vyhledávání: '"Axel Priebsch"'
Autor:
Alexandra Stege, Holger Tönnies, Franziska Rompe, Axel Priebsch, Pawel Surowiak, Verena Materna, Hermann Lage, Petra Kowalski
Publikováno v:
Oligonucleotides. 16(3)
In the chemotherapeutic treatment of patients with disseminated neoplasms, multidrug resistance (MDR) is a major obstacle. ABCG2 (BCRP/MXR), a member of the superfamily of adenosine triphosphate-binding cassette (ABC) transporters, was demonstrated t
Publikováno v:
Biochemical and biophysical research communications. 348(1)
The adenosine triphosphate binding cassette (ABC)-transporter ABCC2 (MRP2/cMOAT) can mediate resistance against the commonly used anticancer drugs cisplatin and paclitaxel. To overcome the ABCC2-depending drug resistance, two specific anti-ABCC2 smal
Publikováno v:
Cancer gene therapy. 11(11)
Multidrug resistance (MDR) is the major cause of failure of effective chemotherapeutic treatment of disseminated neoplasms. The "classical" MDR phenotype of human malignancies is mediated by drug extrusion by the adenosine triphosphate binding casset
Autor:
Axel Priebsch, Franziska Rompe, Holger Tönnies, Petra Kowalski, Pawel Surowiak, Alexandra Stege, Verena Materna, Hermann Lage
Publikováno v:
Oligonucleotides; Fall2006, Vol. 16 Issue 3, p263-274, 12p
Publikováno v:
FEBS Letters. (2-3):144-150
For reversal of MDR1 gene-dependent multidrug resistance (MDR), two small interfering RNA (siRNA) constructs were designed to inhibit MDR1 expression by RNA interference. SiRNA duplexes were used to treat human pancreatic carcinoma (EPP85-181RDB) and