Metabolic Silencing via Methionine-Based Amino Acid Restriction in Head and Neck Cancer

Autor: Anna Chiara Wünsch, Elena Ries, Sina Heinzelmann, Andrea Frabschka, Peter Christoph Wagner, Theresa Rauch, Corinna Koderer, Mohamed El-Mesery, Julian Manuel Volland, Alexander Christian Kübler, Stefan Hartmann, Axel Seher

Publikováno v: Current Issues in Molecular Biology, Vol 45, Iss 6, Pp 4557-4573 (2023)

In recent years, various forms of caloric restriction (CR) and amino acid or protein restriction (AAR or PR) have shown not only success in preventing age-associated diseases, such as type II diabetes and cardiovascular diseases, but also potential f

Externí odkaz: https://doaj.org/article/a6efcf4e5fb74eba82a951acc96392fc

Utilizing BMP-2 muteins for treatment of multiple myeloma.

Autor: Axel Seher, Charlotte Lagler, Thorsten Stühmer, Urs Dietmar Achim Müller-Richter, Alexander Christian Kübler, Walter Sebald, Thomas Dieter Müller, Joachim Nickel

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0174884 (2017)

Multiple myeloma (MM) represents a haematological cancer characterized by the pathological hyper proliferation of antibody-producing B-lymphocytes. Patients typically suffer from kidney malfunction and skeletal disorders. In the context of MM, the tr

Externí odkaz: https://doaj.org/article/3990fafe94fc45b0bc0c29833b01d56b

Mass Spectrometric Metabolic Fingerprinting of 2-Deoxy-D-Glucose (2-DG)-Induced Inhibition of Glycolysis and Comparative Analysis of Methionine Restriction versus Glucose Restriction under Perfusion Culture in the Murine L929 Model System

Autor: Julian Manuel Volland, Johannes Kaupp, Werner Schmitz, Anna Chiara Wünsch, Julia Balint, Marc Möllmann, Mohamed El-Mesery, Kyra Frackmann, Leslie Peter, Stefan Hartmann, Alexander Christian Kübler, Axel Seher

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9220

All forms of restriction, from caloric to amino acid to glucose restriction, have been established in recent years as therapeutic options for various diseases, including cancer. However, usually there is no direct comparison between the different res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d4aa0ad6ca47f6460f4fdae0e44021
https://pubmed.ncbi.nlm.nih.gov/36012485

Cysteine Restriction in Murine L929 Fibroblasts as an Alternative Strategy to Methionine Restriction in Cancer Therapy

Autor: Werner, Schmitz, Elena, Ries, Corinna, Koderer, Maximilian Friedrich, Völter, Anna Chiara, Wünsch, Mohamed, El-Mesery, Kyra, Frackmann, Alexander Christian, Kübler, Christian, Linz, Axel, Seher

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11630, p 11630 (2021)

Methionine restriction (MetR) is an efficient method of amino acid restriction (AR) in cells and organisms that induces low energy metabolism (LEM) similar to caloric restriction (CR). The implementation of MetR as a therapy for cancer or other disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::63289b884bce7f45f996c24059ebf17b

A new multilayered membrane for tissue engineering of oral hard- and soft tissue by means of melt electrospinning writing and film casting – An in vitro study

Autor: Stefan Hartmann, Urs D.A. Müller-Richter, Roman C. Brands, Almoatazbellah Youssef, Axel Seher, Andreas Fuchs, Christian Linz, Alexander C. Kübler

Publikováno v: Journal of Cranio-Maxillofacial Surgery. 47:695-703

Membranes that form a mechanical barrier not only for cells but also for the bacterial flora of the oral cavity may be helpful in infection-free wound healing for guided tissue regeneration (GTR) applications in the field of oral- and maxillofacial s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3788f44b4154ea01d8ec6a1b5bbd1af3
https://doi.org/10.1016/j.jcms.2019.01.043