Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Axel, Paehler"'
Supplementary Video Legends and Figures from BET Inhibition Enhances TNF-Mediated Antitumor Immunity
Autor:
Ricky W. Johnstone, Daniel Rohle, Astrid Ruefli-Brasse, Jake Shortt, Jane Oliaro, Joseph A. Trapani, Stephin J. Vervoort, Conor J. Kearney, Leonie A. Cluse, Axel Paehler, Phillip Thienger, Laura Jarassier, Daniel Marbach, Tanja Fauti, Marina Bacac, Kelly M. Ramsbottom, Jessica Michie, Daniela Geiss, Thomas Friess, Dane M. Newman, Simon J. Hogg, Lisa C. Wellinger
Supplementary Video Legends and Supplementary Figures 1-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596ffec75f56502f7fc3b097790f0b02
https://doi.org/10.1158/2326-6066.22544825.v1
https://doi.org/10.1158/2326-6066.22544825.v1
Autor:
Ricky W. Johnstone, Daniel Rohle, Astrid Ruefli-Brasse, Jake Shortt, Jane Oliaro, Joseph A. Trapani, Stephin J. Vervoort, Conor J. Kearney, Leonie A. Cluse, Axel Paehler, Phillip Thienger, Laura Jarassier, Daniel Marbach, Tanja Fauti, Marina Bacac, Kelly M. Ramsbottom, Jessica Michie, Daniela Geiss, Thomas Friess, Dane M. Newman, Simon J. Hogg, Lisa C. Wellinger
Supp Video 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c0e02c2126b26631873c3c38e9f971
https://doi.org/10.1158/2326-6066.22544813
https://doi.org/10.1158/2326-6066.22544813
Autor:
Ricky W. Johnstone, Daniel Rohle, Astrid Ruefli-Brasse, Jake Shortt, Jane Oliaro, Joseph A. Trapani, Stephin J. Vervoort, Conor J. Kearney, Leonie A. Cluse, Axel Paehler, Phillip Thienger, Laura Jarassier, Daniel Marbach, Tanja Fauti, Marina Bacac, Kelly M. Ramsbottom, Jessica Michie, Daniela Geiss, Thomas Friess, Dane M. Newman, Simon J. Hogg, Lisa C. Wellinger
Supp Video 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce355851a23ce95f918a2f491248d128
https://doi.org/10.1158/2326-6066.22544807.v1
https://doi.org/10.1158/2326-6066.22544807.v1
Autor:
Ricky W. Johnstone, Daniel Rohle, Astrid Ruefli-Brasse, Jake Shortt, Jane Oliaro, Joseph A. Trapani, Stephin J. Vervoort, Conor J. Kearney, Leonie A. Cluse, Axel Paehler, Phillip Thienger, Laura Jarassier, Daniel Marbach, Tanja Fauti, Marina Bacac, Kelly M. Ramsbottom, Jessica Michie, Daniela Geiss, Thomas Friess, Dane M. Newman, Simon J. Hogg, Lisa C. Wellinger
Cell lines used in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5409e92079b8a98efa55398a74dd3414
https://doi.org/10.1158/2326-6066.22544828.v1
https://doi.org/10.1158/2326-6066.22544828.v1
Autor:
Ricky W. Johnstone, Daniel Rohle, Astrid Ruefli-Brasse, Jake Shortt, Jane Oliaro, Joseph A. Trapani, Stephin J. Vervoort, Conor J. Kearney, Leonie A. Cluse, Axel Paehler, Phillip Thienger, Laura Jarassier, Daniel Marbach, Tanja Fauti, Marina Bacac, Kelly M. Ramsbottom, Jessica Michie, Daniela Geiss, Thomas Friess, Dane M. Newman, Simon J. Hogg, Lisa C. Wellinger
Supp Video 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49289504b1b5a29dc58063e8c3cc21c3
https://doi.org/10.1158/2326-6066.22544816
https://doi.org/10.1158/2326-6066.22544816
Autor:
Tanja Fauti, Lisa Wellinger, Joseph A. Trapani, Axel Paehler, Daniela Geiss, Kelly M Ramsbottom, Laura Jarassier, Phillip Thienger, Leonie A. Cluse, Conor J. Kearney, Thomas Friess, Stephin J. Vervoort, Jane Oliaro, Daniel Rohle, Ricky W. Johnstone, Marina Bacac, Simon J. Hogg, Astrid Ruefli-Brasse, Dane M. Newman, Daniel Marbach, Jake Shortt, Jessica Michie
Publikováno v:
Cancer Immunology Research. 10:87-107
Targeting chromatin binding proteins and modifying enzymes can concomitantly affect tumor cell proliferation and survival, as well as enhance antitumor immunity and augment cancer immunotherapies. By screening a small-molecule library of epigenetics-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac19d83f2c4d27f3f848489c76b309bc
https://doi.org/10.1158/2326-6066.cir-21-0224
https://doi.org/10.1158/2326-6066.cir-21-0224
Autor:
Michael Derks, Christoph Wandel, Sian Lennon-Chrimes, Axel Paehler, Piotr Szczesny, Heidemarie Kletzl, Lisa Squassante, Andreas Guenther
Publikováno v:
Expert Opinion on Investigational Drugs. 30:893-901
Balovaptan is a potent, selective vasopressin 1a receptor antagonist. The early-phase pharmacokinetics (PK) of balovaptan are reported.Two Phase 1 studies (overallAbsolute balovaptan bioavailability was high (103-116%). Steady-state (Day 14) balovapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594453fb8d9e29e6cd63b0245011308f
https://doi.org/10.1080/13543784.2021.1948009
https://doi.org/10.1080/13543784.2021.1948009
Autor:
Annabelle Lemenuel-Diot, Felix Jaminion, Valerie Cosson, Qingyan Bo, Sheng Feng, Neil Parrott, Axel Paehler, Yuyan Jin
Publikováno v:
Clinical Pharmacology and Therapeutics
The pharmacokinetics (PK) of RO7049389, a new hepatitis B virus (HBV) core protein allosteric modulator of class I, and of its active metabolite M5 were studied in fasted and fed conditions after single and multiple once-a-day and twice-a-day doses i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af808b3b3bb725ba81f5f7c375575e87
http://europepmc.org/articles/PMC8048879
http://europepmc.org/articles/PMC8048879
Autor:
Sherri Dudal, Caterina Bissantz, Antonello Caruso, Pascale David-Pierson, Wouter Driessen, Erich Koller, Ben-Fillippo Krippendorff, Martin Lechmann, Andrés Olivares-Morales, Axel Paehler, Caroline Rynn, Dietrich Türck, Arthur Van De Vyver, Ken Wang, Lotte Winther
Publikováno v:
Drug discovery today. 27(6)
Many in vitro and in vivo models are used in pharmacological research to evaluate the role of targeted proteins in a disease. Understanding the translational relevance and limitation of these models for analyzing a drug's disposition, pharmacokinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8fe8daa603237350c0a3d96f2e65ff
https://pubmed.ncbi.nlm.nih.gov/35304340
https://pubmed.ncbi.nlm.nih.gov/35304340
Autor:
Daniel Marbach, Daniel Rohle, Daniela Geiss, Thomas Friess, Jake Shortt, Marina Bacac, Jane Oliaro, Kelly M Ramsbottom, Tanja Fauti, Astrid Ruefli-Brasse, Leonie A. Cluse, Dane M. Newman, Ricky W. Johnstone, Lisa Wellinger, Jessica Michie, Conor J. Kearney, Phillip Thienger, Stephin J. Vervoort, Axel Paehler, Laura Jarassier, Simon J. Hogg
Targeting chromatin binding proteins and modifying enzymes can concomitantly affect tumor cell proliferation and survival, as well as enhance anti-tumor immunity and augment cancer immunotherapies. By screening a small molecule library of epigenetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fefe47060c779d85135a4b24dcc425e
https://doi.org/10.1101/2021.02.15.429851
https://doi.org/10.1101/2021.02.15.429851