Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Axel, Kallies"'
Autor:
Patrick M. Gubser, Sharanya Wijesinghe, Leonie Heyden, Sarah S. Gabriel, David P. de Souza, Christoph Hess, Malcolm M. McConville, Daniel T. Utzschneider, Axel Kallies
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114632- (2024)
Summary: Tumor cells undergo uncontrolled proliferation driven by enhanced anabolic metabolism including glycolysis and glutaminolysis. Targeting these pathways to inhibit cancer growth is a strategy for cancer treatment. Critically, however, tumor-r
Externí odkaz:
https://doaj.org/article/ed496fbd2a8c447f9858e95fb3791214
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/f635cfd817e14422aeb01e1c21c5dce2
Autor:
Brendan E. Russ, Adele Barugahare, Pushkar Dakle, Kirril Tsyganov, Sara Quon, Bingfei Yu, Jasmine Li, Jason K.C. Lee, Moshe Olshansky, Zhaohren He, Paul F. Harrison, Michael See, Simone Nussing, Alison E. Morey, Vibha A. Udupa, Taylah J. Bennett, Axel Kallies, Cornelis Murre, Phillipe Collas, David Powell, Ananda W. Goldrath, Stephen J. Turner
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113301- (2023)
Summary: The differentiation of naive CD8+ T lymphocytes into cytotoxic effector and memory CTL results in large-scale changes in transcriptional and phenotypic profiles. Little is known about how large-scale changes in genome organization underpin t
Externí odkaz:
https://doaj.org/article/a6421ddd15594daaa356a1bca492a4ba
Autor:
Mayura V. Wagle, Stephin J. Vervoort, Madison J. Kelly, Willem Van Der Byl, Timothy J. Peters, Ben P. Martin, Luciano G. Martelotto, Simone Nüssing, Kelly M. Ramsbottom, James R. Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A. Miosge, Debbie R. Howard, Renee Gloury, Sarah S. Gabriel, Daniel T. Utzschneider, Jane Oliaro, Jonathan D. Powell, Fabio Luciani, Joseph A. Trapani, Ricky W. Johnstone, Axel Kallies, Christopher C. Goodnow, Ian A. Parish
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Exhausted T cells arise when chronic activation triggers functional defects. Here the authors show that chronic antigenic stimulation in both tumour and infection models induces the expression of EGR2, which drives and stabilises exhausted cell epige
Externí odkaz:
https://doaj.org/article/835402bfc1a5448994d0c742c77cfabd
Autor:
Tom Sidwell, Yang Liao, Alexandra L. Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P. Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R. Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Gordon K. Smyth, Wei Shi, Axel Kallies
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA
Externí odkaz:
https://doaj.org/article/603dfe4ffed14153a4ca1bede6c41d3e
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 8, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/c675d24b65ca47b687f6e29cb3539c69
Autor:
Christina Lückel, Felix Picard, Hartmann Raifer, Lucia Campos Carrascosa, Anna Guralnik, Yajuan Zhang, Matthias Klein, Stefan Bittner, Falk Steffen, Sonja Moos, Federico Marini, Renee Gloury, Florian C. Kurschus, Ying-Yin Chao, Wilhelm Bertrams, Veronika Sexl, Bernd Schmeck, Lynn Bonetti, Melanie Grusdat, Michael Lohoff, Christina E. Zielinski, Frauke Zipp, Axel Kallies, Dirk Brenner, Michael Berger, Tobias Bopp, Björn Tackenberg, Magdalena Huber
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Dimethyl fumarate (DMF) is a therapy for multiple sclerosis (MS) with undetermined mechanism of action. Here the authors find that clinical response to DMF associates with decrease in IL-17-producing CD8+ T cells (Tc17), delineate molecular pathways
Externí odkaz:
https://doaj.org/article/2e2f0c2356834c5db881aabfe09b997c
Autor:
Amy Prosser, Wen Hua Huang, Liu Liu, Sarah Dart, Monalyssa Watson, Bastiaan de Boer, Philip Kendrew, Andrew Lucas, Irma Larma-Cornwall, Silvana Gaudieri, Gary P. Jeffrey, Luc Delriviere, Axel Kallies, Michaela Lucas
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109141- (2021)
Summary: The heterogeneous pool of tissue-resident lymphocytes in solid organs mediates infection responses and supports tissue integrity and repair. Their vital functions in normal physiology suggest an important role in solid organ transplantation;
Externí odkaz:
https://doaj.org/article/4e3d242bf8dc4da199f81b5320e7131f
Publikováno v:
Zootaxa. 5222:69-76
A new species, Oligophlebia hibiscivora Yu, Kallies & Arita sp. nov., is described from south-eastern China. Superficially, it is similar to Oligophlebia insurgia Kallies, 2020 but it differs by external features of the abdomen as well as the male ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb40e730108fe7d689f92f264b42f1f
https://doi.org/10.11646/zootaxa.5222.1.5
https://doi.org/10.11646/zootaxa.5222.1.5
Autor:
Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi J. Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nüssing, Sneha Sant, Zhongfang Wang, Criselle D’Souza, Xiaoxiao Jia, Catarina F. Almeida, Lyudmila Kostenko, Sidonia B. G. Eckle, Bronwyn S. Meehan, Axel Kallies, Dale I. Godfrey, Patrick C. Reading, Alexandra J. Corbett, James McCluskey, Paul Klenerman, Katherine Kedzierska, Timothy S. C. Hinks
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
MAIT cells are abundant in the lungs and confer protection against bacterial pathogens. Whilst activation of these cells has been described during viral infections, here van Wilgenburg and colleagues show that in a murine model MAIT cells contribute
Externí odkaz:
https://doaj.org/article/e15ac8dd044648a69319eb56458d539f